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L. Simões da Silva,Ana M. Girão Coelho,Rui A.D. Simões 국제구조공학회 2001 Steel and Composite Structures, An International J Vol.1 No.2
The analysis of steel-concrete composite joints presents some particular aspects that increase their complexity when compared to bare steel joints. In particular, the influence of slab reinforcement and column concrete encasement clearly change the moment-rotation response of the joint. Starting from an energy approach developed in the context of steel joints, an extension to composite joints is presented in this paper that is able to provide closed-form analytical solutions. In addition, the possibility of tri-linear or non-linear component behaviour is also incorporated in the model, enabling adequate treatment of the influence of cracked concrete in tension and the softening response of the column web in compression. This methodology is validated through comparison with experimental tests carried out at the University of Coimbra.
Nuno Trovão,Joana Prata,Orlando VonDoellinger,Susana Santos,Mário Barbosa,Rui Coelho 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.3
ObjectiveaaSchizophrenia is a disabling disorder of unknown aetiology, lacking definite diagnostic method and cure. A reliable biological marker of schizophrenia is highly demanded, for which traceable immune mediators in blood could be promising candidates. We aimed to gather the best findings of neuroinflammatory markers for first-episode psychosis (FEP). MethodsaaWe performed an extensive narrative review of online literature on inflammation-related markers found in human FEP patients only. ResultsaaChanges to cytokine levels have been increasingly reported in schizophrenia. The peripheral levels of IL-1 (or its receptor antagonist), soluble IL-2 receptor, IL-4, IL-6, IL-8, and TNF-α have been frequently reported as increased in FEP, in a suggestive continuum from high-risk stages for psychosis. Microglia and astrocytes establish the link between this immune signalling and the synthesis of noxious tryptophan catabolism products, that cause structural damage and directly hamper normal neurotransmission. Amongst these, only 3-hydroxykynurenine has been consistently described in the blood of FEP patients. ConclusionaaPeripheral molecules stemming from brain inflammation might provide insightful biomarkers of schizophrenia, as early as FEP or even prodromal phases, although more time- and clinically-adjusted studies are essential for their validation.
Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art
Celeste Silveira,Renato Guedes,Diana Maia,Rosário Curral,Rui Coelho 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.12
Multiple Sclerosis (MS) is a chronic disabling neuroinflammatory disease. Psychiatric manifestations have a high prevalence in MS patients and may worsen the illness progression and the patients’ quality of life (QoL). Depression is a highly prevalent condition in MS patients, associated with poorer adherence to treatment, decreased functional status and QoL, and increased suicide risk. Diagnosis and treatment of this disorder is challenging because of symptom overlap. Other prevalent psychiatric comorbidities are anxiety disorders, bipolar disorder, psychotic disorders, substance misuse and personality disorders. As the illness progresses, personality changes can happen, as well as affect abnormalities. Cognitive changes occur frequently in MS patients, and affect features like processing speed, attention, learning, memory, visual spatial capabilities, and some language deficits. Disease-modifying treatments may reduce cognitive impairment because of their container action on the brain’s lesion burden. Other QoL determinants such as fatigue, pain, sexual dysfunction, exercise, resilience and social support should be taken into account, in order to promote the individuals’ well-being. Further studies are needed in order to elucidate the effectiveness of pharmacotherapy and more neuroimaging studies are required to clarify the relationship between structural changes and psychiatric comorbidities.
David Villanueva-Bermejo,Tiziana Fornari,Maria V. Calvo,Javier Fontecha,Jose A.P. Coelho,Rui M. Filipe,Roumiana P. Stateva 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.82 No.-
The kinetics of the supercriticalfluid extraction of edible and discarded chia seeds was studied andmodelled for thefirst time. The total oil was removed at 45 MPa and 60 C after 240 min. The extractionkinetics was simulated using a dynamic model in gPROMS ModelBuilder environment and the kineticparameters estimated. Triolein was chosen as a model compound of the chia oil. The agreement betweenthe experimental yields and those calculated by the model was good with deviations in the range(1.2–6.6) %, except at 25 MPa and 60 C (AARD = 9.5%).