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Rramaswamy Ravikumar,Mei Mei Peng,Aziz Abidov,Cadiam Mohan Babu,Rajangam Vinodh,Muthiahpillai Palanichamy,Eun Young Choi,Hyun-Tae Jang 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.2
For treating the chronic illnesses, the best choice of drug delivery might be the controlled drug delivery systems. Nanoscaled drug delivery systems like nanofibres, nanoparticles are in the advancement of the controlled drug delivery system. Nanofibres are being a good choice due to its advantages like high drug loading and encapsulation efficiency. The present study is concerned with the synthesis of simple electrospunned nanofibres of Chitosan (CHI)/Polyvinyl alcohol (PVA) blended with Hydroxy ethyl cellulose (HEC) which will be preloaded with a model chemotherapeutic agent 5-Fluorouracil (5-FU) before electrospinning. HEC is chosen for its capability of enhancing the nanofiber formation since it is used as the thickening agents in several fields. The various mixture proportions of HEC and PVA blends were tried to form electrospunned fibers and characterized usingFT-IT, SEM, TGA and UV-VIS (for drug release study). The data output strengthening that HEC might be used to get the optimum nanofibre in the CHI/PVA nanofibre preparation which may be useful for controlled releasing of the drugs like 5-FU for treating colo-rectal cancer like chronic illnesses.
Caprolactam Synthesis using Ce-MCM-41Catalysts
Cadiam Mohan Babu,Rajangam Vinodh,Aziz Abidov,Rramaswamy Ravikumar,Mei Mei Peng,Wang Seog Cha,Hyun Tae Jang 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.3
Siliceous MCM-41 was synthesized by hydrothermal method using sodiummetasilicate as a source. Cerium ion incorporated Si-MCM-41 was synthesized by hydrothermal method using Cetyltrimethylammonium bromide as template. 2, 3 and 4 weight percentage of Ceria was loaded over MCM-41 by wet impregnation method. The synthesized catalysts were characterized using FT-IR, DRS-UV-Vis, XRD and SEM techniques. The catalytic activity of the cerium ion incorporated and ceria impregnated MCM-41 was evaluated in the synthesis of caprolactam from cyclohexanone oxime in the liquid phase condition. At high temperature all the catalyst showed high conversion. In that 4 wt.% Ce impregnated Si-MCM-41 produced high conversion (76.2%) and percentage yield (66.4%). The impregnated catalyst may contain more number of cerium present in the pores, so the lewis acid sites will be more and the conversion of cyclohexanone oxime into caprolactam will be high.
Synthesis and Characterization of 1-octyl 2-cyano Acrylate for Wound Healing Applications
Rajangam Vinodh,Cadiam Mohan Babu,Aziz Abidov,Rramaswamy Ravikumar,Muthiahpillai Palanichamy,Eun Young Choi,Hyun Tae Jang 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.1
Cyanoacrylate glues are quick setting materials which rapidly cure to hard, clear glassy resins. Its synthesis too has not been reported in the open literature so far. Synthetic methods, which engage esterification of cyanoacetic acid with a preferred alcohol, polymerization by knoevenagel condensation and successive depolymerization, are applied to the synthesis of lower membered alkyl cyanoacryaltes in which the alkyl groups carry less than 8 carbons. We have synthesized 1-octyl cyanoacetate by a traditional method involving p-toluene sulphonic acid as the catalyst. In the second step, we have attempted the preparation of poly (n-octyl cyanoacrylate) by the reaction of formaldehyde with n-octyl-2-cyanoacetate in the presence of both piperidine and potassium carbonate in the absence of any solvents. Its FTIR spectrum confirmed its functional groups: Its –OH stretching yielded a broad band around 3400 cm-1. The polymer was depolymerized using poly phosphoric acid catalyst under vacuum to obtain the monomer. A simple method of obtaining monomer was also attempted by the reaction of 1-octyl- 2-cyano acetate and diiodomethane in the presence of potassium carbonate. This process directly yields the monomer. The second method looks better than the others, and it can be applied to any type of alcohols.
Mani Ganesh,Abidov Sch Aziz,Udumansha Ubaidulla,Pushparaj Hemalatha,Arthanari Saravanakumar,Rramaswamy Ravikumar,Mei Mei Peng,최은영,장현태 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.39 No.-
Novel silver nanoparticles-decorated chitosan (CS)-polyvinyl alcohol (PVA) composite electrospunnanofibers, loaded with sulfanilamide for enhanced wound healing have been developed. Herein, formicacid was used as a reducing agent to produce in situ colloidal silver nanoparticles (AgNPs) in thecomposite polymeric solution with the active agent sulfanilamide. The prepared electrospun fiberswere characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM),X-ray diffraction, ultraviolet spectroscopy, and thermal gravimetric analysis (TG). Further, in vitrorelease, antimicrobial properties and in vivo wound healing activity were evaluated. The results revealedthat the composite fibers displayed a synergistic antibacterial and wound healing activities.