A rare case of osteonecrosis of the jaw related to imatinib

Massimo Viviano,Marco Rossi,Serena Cocca 대한구강악안면외과학회 2017 대한구강악안면외과학회지 Vol.43 No.2

Osteonecrosis of the jaw (ONJ) is commonly described as an adverse effect of the use of bisphosphonates. A few cases of ONJ associated with tyrosine kinase inhibitors (sunitinib, imatinib) have been reported in the literature and usually they occurred in patients simultaneously treated with bisphosphonates. We report an atypical case of ONJ related only to imatinib. A 72-year-old male patient was treated with imatinib for metastases from gastrointestinal stromal tumors (GISTs). The patient developed ONJ after 22 months of imatinib only therapy. During his whole life, the patient had never been treated with bisphosphonates or radiotherapy. Microscope examination of the tissues confirmed the clinical diagnosis of diffuse osteonecrosis and showed absence of neoplastic cells. Thus, secondary localisations from GISTs were ruled out. Osteonecrosis of the lower jaw appeared 22 months after initial and exclusive therapy with imatinib. Therefore, imatinib monotherapy can induce ONJ in patients that have never been treated with bisphosphonates or radiotherapy.

Percutaneous trans-hepatic rescue and neo-creation of a post-surgical complete hepaticojejunostomy dehiscence

Umberto Geremia Rossi,Andrea DeCensi,Gian Andrea Rollandi,Marco Filauro 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.3

Biliary leakage complicating hepaticojejunostomy is a therapeutic dilemma for surgeons, gastroenterologist, and interventional radiologist. It is a major cause of postoperative morbidity. Percutaneous biliary intervention techniques have been developed for treating benign post-surgical biliary disease in patients not having severely compromised clinical conditions. Interventional radiology manoeuvres are especially indicated as the first line of treatment if endoscopic procedures are unfeasible for patients due to postsurgical anatomical modifications. We present a case of post-surgical complete hepaticojejunostomy dehiscence that was treated totally by percutaneous techniques with trans-hepatic rescue and hepaticojejunostomy neo-creation.

Effects of Chrysin on Urinary Testosterone Levels in Human Males

Cristiana Gambelunghe,Ruggero Rossi,Marco Sommavilla,Chiara Ferranti,Riccardo Rossi,Chiara Ciculi,Stefania Gizzi,Alessandra Micheletti,Stefano Rufini 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.4

The equilibrium of sexual hormones in both sexes is controlled in vertebrates by the enzyme aromatase, amember of the cytochrome P450 superfamily, which catalyzes the conversion of androstenedione and testosterone into es-trone and estradiol, respectively. Flavonoids are diphenolic compounds present in whole grains, legumes, fruits, and vegeta-bles that are strongly implicated as protective in coronary heart disease, stroke, and cancer. One flavonoid, chrysin, found inhigh concentrations in honey and propolis, has been shown to be an inhibitor of aromatase enzyme activity. These foods areoften used as supplements, particulary by sportsmen for their energetic and antioxidant properties. The aim of this study wasto verify if daily treatment for 21 days with propolis and honey, containing chrysin, would modify urinary concentrations oftestosterone in volunteer male subjects. In fact, aromatase inhibition by chrysin could block the conversion of androgens intoestrogens with a consequent increase of testosterone, eventually measurable in urine samples. The obtained data did not showalterations of the levels of testosterone in the volunteers after 7, 14, and 21 days of treatment in comparison with baselinevalues and compared with measurements on the control subjects at the same time. In conclusion, the use of these foods for21 days at the doses usually taken as oral supplementation does not have effects on the equilibrium of testosterone in humanmales.

Results of the CCRI(II)-S12.H-3 supplementary comparison: Comparison of methods for the calculation of the activity and standard uncertainty of a tritiated-water source measured using the LSC-TDCR method

Cassette, Philippe,Altzitzoglou, Timotheos,Antohe, Andrei,Rossi, Mario,Arinc, Arzu,Capogni, Marco,Galea, Raphael,Gudelis, Arunas,Kossert, Karsten,Lee, K.B.,Liang, Juncheng,Nedjadi, Youcef,Oropesa Verd Elsevier 2018 Applied radiation and isotopes Vol.134 No.-

<P><B>Abstract</B></P> <P>A comparison of calculations of the activity of a <SUP>3</SUP>H<SUB>2</SUB>O liquid scintillation source using the same experimental data set collected at the LNE-LNHB with a triple-to-double coincidence ratio (TDCR) counter was completed. A total of 17 laboratories calculated the activity and standard uncertainty of the LS source using the files with experimental data provided by the LNE-LNHB. The results as well as relevant information on the computation techniques are presented and analysed in this paper. All results are compatible, even if there is a significant dispersion between the reported uncertainties. An output of this comparison is the estimation of the dispersion of TDCR measurement results when measurement conditions are well defined.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Comparison of calculations of the activity of a <SUP>3</SUP>H<SUB>2</SUB>O LS source from the same experimental data set. </LI> <LI> Data set from a triple-to-double coincidence ratio (TDCR) counter. </LI> <LI> 17 laboratories participated in this exercise. </LI> <LI> Results and relevant information on the computation techniques are presented and analysed. </LI> <LI> All results are compatible but significant dispersion of the reported uncertainties. </LI> </UL> </P>

Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells

De Robertis, Alessandra,Valensin, Silvia,Rossi, Marco,Tunici, Patrizia,Verani, Margherita,De Rosa, Antonella,Giordano, Cinzia,Varrone, Maurizio,Nencini, Arianna,Pratelli, Carmela,Benicchi, Tiziana,Bak American Association for Cancer Research 2013 Molecular cancer therapeutics Vol.12 No.7

<P>Glioblastoma multiforme (GBM) is the most common and prognostically unfavorable form of brain tumor. The aggressive and highly invasive phenotype of these tumors makes them among the most anatomically damaging human cancers with a median survival of less than 1 year. Although canonical Wnt pathway activation in cancers has been historically linked to the presence of mutations involving key components of the pathway (APC, β-catenin, or Axin proteins), an increasing number of studies suggest that elevated Wnt signaling in GBM is initiated by several alternative mechanisms that are involved in different steps of the disease. Therefore, inhibition of Wnt signaling may represent a therapeutically relevant approach for GBM treatment. After the selection of a GBM cell model responsive to Wnt inhibition, we set out to develop a screening approach for the identification of compounds capable of modulating canonical Wnt signaling and associated proliferative responses in GBM cells. Here, we show that the small molecule SEN461 inhibits the canonical Wnt signaling pathway in GBM cells, with relevant effects at both molecular and phenotypic levels <I>in vitro</I> and <I>in vivo</I>. These include SEN461-induced Axin stabilization, increased β-catenin phosphorylation/degradation, and inhibition of anchorage-independent growth of human GBM cell lines and patient-derived primary tumor cells <I>in vitro</I>. Moreover, <I>in vivo</I> administration of SEN461 antagonized Wnt signaling in <I>Xenopus</I> embryos and reduced tumor growth in a GBM xenograft model. These data represent the first demonstration that small-molecule–mediated inhibition of Wnt signaling may be a potential approach for GBM therapeutics. <I>Mol Cancer Ther; 12(7); 1180–9. ©2013 AACR</I>.</P>

Erector spinae plane block in children: a narrative review

Lucente Monica,Ragonesi Giulia,Sanguigni Marco,Sbaraglia Fabio,Vergari Alessandro,Macchia Rosa La,Antonicelli Federica,Rossi Marco 대한마취통증의학회 2022 Korean Journal of Anesthesiology Vol.75 No.6

The erector spinae plane block (ESPB) is a novel technique used in both adult and pediatric patients. Its use in children has mostly been described in terms of perioperative pain management for various types of surgery. After its introduction, anesthesiologists began using ESPBs in various surgical settings. As adequate analgesia along with a low complication rate were reported, interest in this technique dramatically increased. Many studies in adults and children, including randomized controlled trials, have been published, resulting in the emergence of different clinical indications, with various technical and pharmacological approaches currently evident in the literature. This narrative review aims to analyze the current evidence in order to guide practitioners towards a more homogeneous approach to ESPBs in children, with a major focus on clinical applications. The ESPB is an efficient, safe, and relatively easy technique to administer. It can be applied in a wide range of surgeries, includes thoracic, abdominal, hip, and femur surgery. Its usefulness is evident in the context of enhanced recovery after surgery protocols and multimodal analgesia. Single-shot, intermittent bolus, and continuous infusion techniques have been described, and non-inferiority has been observed when compared with other locoregional techniques. Even though both the efficacy and safety of the procedure are widely accepted, current evidence is predominantly based on case reports, with very few well-designed observational studies. Consequently, the level of evidence is still poor, and more well-designed double-blind, randomized, placebo-controlled trials are needed to refine the procedure for different clinical applications in the pediatric population.