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- 저자 : Alessandra Micheletti (검색결과 1 건)
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Effects of Chrysin on Urinary Testosterone Levels in Human Males
Cristiana Gambelunghe,Ruggero Rossi,Marco Sommavilla,Chiara Ferranti,Riccardo Rossi,Chiara Ciculi,Stefania Gizzi,Alessandra Micheletti,Stefano Rufini 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.4
The equilibrium of sexual hormones in both sexes is controlled in vertebrates by the enzyme aromatase, amember of the cytochrome P450 superfamily, which catalyzes the conversion of androstenedione and testosterone into es-trone and estradiol, respectively. Flavonoids are diphenolic compounds present in whole grains, legumes, fruits, and vegeta-bles that are strongly implicated as protective in coronary heart disease, stroke, and cancer. One flavonoid, chrysin, found inhigh concentrations in honey and propolis, has been shown to be an inhibitor of aromatase enzyme activity. These foods areoften used as supplements, particulary by sportsmen for their energetic and antioxidant properties. The aim of this study wasto verify if daily treatment for 21 days with propolis and honey, containing chrysin, would modify urinary concentrations oftestosterone in volunteer male subjects. In fact, aromatase inhibition by chrysin could block the conversion of androgens intoestrogens with a consequent increase of testosterone, eventually measurable in urine samples. The obtained data did not showalterations of the levels of testosterone in the volunteers after 7, 14, and 21 days of treatment in comparison with baselinevalues and compared with measurements on the control subjects at the same time. In conclusion, the use of these foods for21 days at the doses usually taken as oral supplementation does not have effects on the equilibrium of testosterone in humanmales.
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