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      • Association between GSTP1 Genotypes and Hormone Receptor Phenotype in Invasive Ductal Carcinomas of Breast

        Khabaz, Mohamad Nidal,Gari, Mamdooh Abdullah,Al-Maghrabi, Jaudah Ahmed,Nedjadi, Taoufik,Bakarman, Marwan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

        Eighty six cases of invasive ductal breast carcinomas were utilized to investigate GSTP1 polymorphisms in certain immunohistochemistry (IHC) subtypes of breast cancer with respect to ER, PR and HER2 expression. The frequency of wild allele homozygote, heterozygote and variant allele homozygote genotypes were 46.5%, 52.3% and 1.16% respectively; Whereas 54.3% of the control subjects were GSTP1 wild type allele homozygous, 40.0% were heterozygous and 5.71% mutant allele homozygous. There was dramatic inverted relation between positive IHC ER staining and increasing grade of tumors in general (100%, 88.6%, 40.4%) and especially among tumors with heterozygote genotype of GSTP1 (70%, 35.4%, 22.7). There was increase in positive IHC HER2 staining consistent with higher grades in general (20%, 29.6%, 50.0%), especially among tumors with GSTP1 wild allele homozygote genotype (5.0%, 9.1%, 31.8%). A remarkable reverse relation was also observed between the fraction of IHC hormone receptor phenotype ER+/PR+/ HER2- and increased grade of tumors (60.0%, 45.5%, and 27.3%) especially among tumors with GSTP1 heterozygote genotype, and a similar link was noted regarding ER+/PR-/ HER2- and tumor grade. There was increase in frequency of ER-/PR-/ HER2- (0.0%, 6.8%, and 18.2%) and ER-/PR-/ HER2+ (0.0%, 4.54%, and 40.9%) consistent with the higher grades of tumors in general and especially GSTP1 heterozygote genotype tumors. As a conclusion, there is no correlation between GSTP1 polymorphism and increased risk of breast cancer i.e. the mutant allele is randomly distributed in cancer and control cases. However, there is a link between GSTP1 genotypes and hormone receptor expression status and certain phenotypes of breast cancer, which may have clinical importance.

      • Results of the CCRI(II)-S12.H-3 supplementary comparison: Comparison of methods for the calculation of the activity and standard uncertainty of a tritiated-water source measured using the LSC-TDCR method

        Cassette, Philippe,Altzitzoglou, Timotheos,Antohe, Andrei,Rossi, Mario,Arinc, Arzu,Capogni, Marco,Galea, Raphael,Gudelis, Arunas,Kossert, Karsten,Lee, K.B.,Liang, Juncheng,Nedjadi, Youcef,Oropesa Verd Elsevier 2018 Applied radiation and isotopes Vol.134 No.-

        <P><B>Abstract</B></P> <P>A comparison of calculations of the activity of a <SUP>3</SUP>H<SUB>2</SUB>O liquid scintillation source using the same experimental data set collected at the LNE-LNHB with a triple-to-double coincidence ratio (TDCR) counter was completed. A total of 17 laboratories calculated the activity and standard uncertainty of the LS source using the files with experimental data provided by the LNE-LNHB. The results as well as relevant information on the computation techniques are presented and analysed in this paper. All results are compatible, even if there is a significant dispersion between the reported uncertainties. An output of this comparison is the estimation of the dispersion of TDCR measurement results when measurement conditions are well defined.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Comparison of calculations of the activity of a <SUP>3</SUP>H<SUB>2</SUB>O LS source from the same experimental data set. </LI> <LI> Data set from a triple-to-double coincidence ratio (TDCR) counter. </LI> <LI> 17 laboratories participated in this exercise. </LI> <LI> Results and relevant information on the computation techniques are presented and analysed. </LI> <LI> All results are compatible but significant dispersion of the reported uncertainties. </LI> </UL> </P>

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