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Rongxin Liao,Kehong Chen,Jinjin Li,Hengqiu He,Guangming Yi,Mingfeng Huang,Rongrong Chen,Lu Shen,Xiaoyue Zhang,Zaicheng Xu,Zhenzhou Yang,Yuan Peng 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3
Purpose Oligometastatic non–small cell lung cancer (NSCLC) patients have been increasingly regarded as a distinct group that could benefit from local treatment to achieve a better clinical outcome. However, current definitions of oligometastasis are solely numerical, which are imprecise because of ignoring the biological heterogeneity caused by genomic characteristics. Our study aimed to profile the molecular alterations of oligometastatic NSCLC and elucidate its potential difference from polymetastasis. Materials and Methods We performed next-generation sequencing to analyze tumors and paired peripheral blood from 77 oligometastatic and 21 polymetastatic NSCLC patients to reveal their genomic characteristics and assess the genetic heterogeneity. Results We found ERBB2, ALK, MLL4, PIK3CB, and TOP2A were mutated at a significantly lower frequency in oligometastasis compared with polymetastasis. EGFR and KEAP1 alterations were mutually exclusive in oligometastatic group. More importantly, oligometastasis has a unique significant enrichment of apoptosis signaling pathway. In contrast to polymetastasis, a highly enriched COSMIC signature 4 and a special mutational process, COSMIC signature 14, were observed in the oligometastatic cohort. According to OncoKB database, 74.03% of oligometastatic NSCLC patients harbored at least one actionable alteration. The median tumor mutation burden of oligometastasis was 5.00 mutations/Mb, which was significantly associated with smoking, DNA damage repair genes, TP53 mutation, SMARCA4 mutation, LRP1B mutation, ABL1 mutation. Conclusion Our results shall help redefine oligometastasis beyond simple lesion enumeration that will ultimately improve the selection of patients with real oligometastatic state and optimize personalized cancer therapy for oligometastatic NSCLC.
Wang Rongxin,An Aimin,Wen Yongan,Song Houbin 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.3
This article presents a parallel fuzzy PID control strategy on a bulb tubular turbine generator unit for improving the robust control performance. First, the nonlinear model of a bulb tubular turbine generator unit is built in MATLAB/Simulink, and the PID controller parameters are adjusted under rated head. Then, an integrated fuzzy logic PID controller is designed to regulate the hydraulic turbine unit. The eff ectiveness and robustness capability of the proposed controller are evaluated in four independent experiments: starting process, load rejection, frequency tracking and frequency interference. The experimental results validate that the proposed controller can signifi cantly improve the response performance of the speed of hydraulic turbine units. The coeffi cient mutation experiment reveals that the robustness of the system has been improved obviously, and unique contributions of the work can provide a reference for the optimal control of bulb tubular turbine generator units.
Yongliang Wang,Rongxin Ma,Lizhu Liu,Zhanchun Xu,Fenghui Li 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.8
As one of the electrode materials for supercapacitor, Co3O4/graphene composite was mainly synthesized via two-steps method. Here, a facile one-pot method was used for Co3O4/graphene composite, and the performances of one-pot-synthesized Co3O4/graphene composite were carefully investigated. Liquid-phase exfoliation was used for graphene and the D-band/G-band ratio of liquid-phase exfoliated graphene was only 0.094, which indicated that the graphene had low defect density and enhanced electrical conductivity. Morphologies investigation of Co3O4/graphene composites indicated that Co3O4 nanoparticles with mean diameter of 14 nm were uniformly anchored on graphene sheets. The facile one-pot method associated with liquid-phase exfoliated graphene induced Co3O4/graphene composite with enhanced specific capacitance of 392 F · g -1 at a current density of 1 A · g -1. The Co3O4/graphene composite also expressed relatively small internal resistance and diffusion resistance (0.36 Ω and 0.45 Ω, respectively). Moreover, the synthesized Co3O4/graphene composite yielded excellent rate performances with only 9.5% capacitance loss when current density was increased by a factor of 10.
A Coverage Algorithm for Multiple Autonomous Surface Vehicles in Flowing Environments
Weisheng Yan,Lei Zuo,Rongxin Cui,Jian Gao 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.2
This paper is concerned with the coverage problem with multiple autonomous surface vehicles (ASVs) intime-varying flowing environment, where the interest information distribution is unknown to the coverage networks. While taking the model parameter uncertainty into consideration, a decentralized, adaptive control law is proposedsuch that the coverage network will converge to the optimal assigned region from arbitrary positions. For easeof exploration, we first investigate the static coverage problem of two-agent systems in flowing environment andpresent an example by extending the two-agent systems into the general case. In addition, Gaussian Estimationis introduced to predict the value of the sensory function through the sampled measurements. By using the staticcoverage partition as theoretical foundation, we transform the optimal coverage control into the moving targettracking problems, where the target is the centroid of the assigned region for each ASV. Based on these techniques,a decentralized kinematic control algorithm is developed to navigate the multi-ASV systems. Furthermore, theadaptive back-stepping techniques are employed to extend the kinematic controller into dynamic case with uncertainmodel parameters. Finally, simulation studies are provided to demonstrate the feasibility and effectiveness of theproposed approaches.
Market States and Lottery Preference: Evidence from Chinese Open-End Funds
Hsieh Pei‐Lin,He Rongxin 한국증권학회 2023 Asia-Pacific Journal of Financial Studies Vol.52 No.5
Recent studies find that investors prefer funds with lottery‐like payoffs. Using a sample of Chinese open‐end funds, we show that investors' preference for funds' extreme positive payoffs (MAXs) depend on the state of the market: it is significant for MAXs in an unfavorable market but weak or reversed for those in a favorable market. Such state‐dependent preference is irrational because, inconsistent with the flow–MAX relationship, higher MAXs under market downturns are associated with worse performance. We further document support for the salience‐theory‐based explanation for investors' preference and provide counter‐evidence for alternative mechanisms based on rational choice or changes in aggregate flows.