EXPERIMENTAL RESEARCH OF VORTEX STRUCTURE OF THE FLOW AROUND A HORIZONTAL CIRCULAR CYLINDER AT VARIOUS GAP-RATIOS IN THE CROSS-FLOW OF SHALLOW WATER

QI E-RONG,LI GUO-YA,LI WEI,WU JIAN,ZHANG XIN 한국수자원학회 2005 한국수자원학회 학술대회 Vol.2005 No.1

Dendritic Cells Induce Specific Cytotoxic T Lymphocytes against Prostate Cancer TRAMP-C2 Cells Loaded with Freeze-thaw Antigen and PEP-3 Peptide

Liu, Xiao-Qi,Jiang, Rong,Li, Si-Qi,Wang, Jing,Yi, Fa-Ping Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

Prostate cancer is the most common cancer in men. In this study, we investigated immune responses of cytotoxic T lymphocytes (CTLs) against TRAMP-C2 prostate cancer cells after activation by dendritic cells (DCs) loaded with TRAMP-C2 freeze-thaw antigen and/or PEP-3 peptide in vitro. Bone marrow-derived DC from the bone marrow of the C57BL/6 were induced to mature by using the cytokine of rhGM-CSF and rhIL-4, and loaded with either the freeze-thaw antigen or PEP-3 peptide or both of them. Maturation of DCs was detected by flow cytometry. The killing efficiency of the CTLs on TRAMP-C2 cells were detected by flow cytometry, CCK8, colony formation, transwell migration, and wound-healing assay. The levels of the IFN-${\gamma}$, TNF-${\beta}$ and IL-12 were measured by enzyme-linked immunosorbent assay (ELISA). Compared with the unloaded DCs, the loaded DCs had significantly increased expression of several phenotypes related to DC maturation. CTLs activated by DCs loaded with freeze-thaw antigen and PEP-3 peptide had more evident cytotoxicity against TRAMP-C2 cells in vitro. The secretion levels of IFN-${\gamma}$, TNF-${\beta}$ and IL-12, secreted by DCs loaded with antigen and PEP-3 and interaction with T cells, were higher than in the other groups. Our results suggest that the CTLs activated by DCs loaded with TRAMP-C2 freeze-thaw antigen and PEP-3 peptide exert a remarkable killing efficiency against TRAMP-C2 cells in vitro.

Study on the Transmission Error Prediction for a Spur Gear Pair

Qi Zhang(장기),Jing Zhang(장정),Zhong Gang Zhu(주충강),Zhen Rong Wang(왕진영),Zhe-zhu Xu(허철수),Sung Ki Lyu(류성기) Korean Society for Precision Engineering 2016 한국정밀공학회지 Vol.33 No.2

Preparation and properties of morphology controlled poly(2-hydroxyethyl methacrylate)/poly(N-vinyl pyrrolidone) double networks for biomedical use

Qi Tang,Jun-Rong Yu,Lei Chen,Jing Zhu,Zu-Ming Hu 한국물리학회 2010 Current Applied Physics Vol.10 No.3

Poly(2-hydroxyethyl methacrylate)/poly(N-vinyl pyrrolidone) (PHEMA/PVP) double networks (DN) were prepared using a sequential method by incorporating a second network of crosslinked PVP into PHEMA. We found that the distributions of the two networks can be regulated just by modulating the morphology of the first network, thus giving expected high water content of these gels. Fourier transform infrared (FTIR) spectroscopy and scanning electronic microscopy (SEM) were used to confirm the structure of the DN. The incorporation of more hydrophilic PVP enhanced swelling ability of these gels. Because of improved hydrophilicity, the PHEMA/PVP DN exhibited higher loading capability for water-soluble substance than that of pure PHEMA, while showed a slower release rate than corresponding HEMA/NVP copolymer hydrogel. It is suggested that the DN gels are potential biomaterials for wound dressing, medical implants and other drug delivery systems.

An improved SCGM(1,m) model for multi-point deformation analysis

Qi-jie Wang,Chang-cheng Wang,Rong-an Xie,Xin-qing Zhang,Jian-jun Zhu 한국지질과학협의회 2014 Geosciences Journal Vol.18 No.4

Considering the deformation of discrete monitoringpoints within the same deformable body usually have similar physicalproperties and tend to undergoing identical dynamic process, jointmodelling of the deformation processes of these points in time domainare expected to generate better results. Yin et al. (1997) first extendedthe multi-variable grey model-system cloud grey model SCGM(1,m),with obviously superior modelling mechanism than single-variablegrey model, to multi-point deformation modelling. However, thismodel is still not widely recognized and its applications remain verylimited in the field of deformation analysis. The objective of this studyis to demonstrate the capability of the SCGM(1,m) model, to presenttwo revisions to further improve the performance of the model andto draw more attention to the community of deformation analysis. We first introduce the principles of the SCGM(1,m) model in theanalysis and prediction of deformation surveys. Two practicaltechniques, namely residuals re-modelling and linear regressionadjustment, are then presented to improve the SCGM(1,m) model. Combined with slope monitoring data, the modelling with the originaland the improved SCGM(1,m) models by residuals re-modellingand linear regression adjustment are illustrated. The mean relativeprediction errors decrease from 5.89% to 3.54% and 2.69%, whenthe two refining techniques are applied, respectively, indicating relativeimprovements of 39.9% and 54.3%.

Knockdown of endogenous SKIP gene enhance insulin-induced glycogen synthesis signaling differentiating C2C12 myoblasts

( Qi Xiong ),( Chang Yan Deng ),( Jin Chai ),( Si Wen Jiang ),( Yuan Zhu Xiong ),( Feng E Li ),( Rong Zheng ) 생화학분자생물학회 2009 BMB Reports Vol.42 No.2

Poly (dimethyl siloxane)/poly (2-hydroxyethyl methacrylate) interpenetrating polymer network beads as potential capsules for biomedical use

Qi Tang,Jun-Rong Yu,Lei Chen,Jing Zhu,Zu-Ming Hu 한국물리학회 2011 Current Applied Physics Vol.11 No.3

Silicone hydrogels represent a series of novel materials designed for extensive applications especially in the biomedical field. In the current work, a method to obtain poly (dimethyl siloxane)/poly (2-hydroxyethyl methacrylate) (PDMS/PHEMA) interpenetrating polymer network (IPN) beads was developed. With further optimization, up to 43% PHEMA was incorporated into size controllable PDMS microspheres,offers an improved hydrophilicity and thus a reduced protein adsorption for long-term use. Furthermore, we found the PDMS/PHEMA IPN beads possess a hollow capsule-like structure, proposing their application as novel drug delivery vehicles. In vitro release studies have demonstrated two release patterns of these IPN beads for water-soluble drugs just by modulating the drug concentration, suggesting their possible applications in different delivery systems.

Effectiveness and safety of acupuncture for angina pectoris: An overview of systematic reviews

Qi Wen-Chuan,Fu Hong-Juan,Sun Rui-Rui,Li Xiang,Cai Ding-Jun,Wang Chao,Liang Fan-Rong 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.3

Background: The number of systematic reviews or meta-analyses (SRs/MAs) on the effectiveness of acupuncture for angina pectoris (AP) is increasing. Due to the inconsistent conclusions and unknown quality of these SRs/MAs, this overview aimed to systematically evaluate and synthesize the existing SRs/MAs, attempting to provide more reliable evidence for the effectiveness and safety of acupuncture in the treatment of AP. Methods: SRs/MAs were searched via eight databases from inception to March 14, 2022. The risk of bias was evaluated using the Risk of Bias in Systematic reviews (ROBIS) tool. The quality of the methodology, reporting, and evidence were assessed by the Assess Systematic Reviews 2 (AMSTAR-2), the Preferred Reporting Item for Systematic Review and Meta-analysis for Acupuncture (PRISMA-A), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system, respectively. Results: Sixteen SRs/MAs were included and fifteen SRs/MAs were considered being of critically low quality according to AMSTAR-2. Only three SRs/MAs were rated at low risk of bias. No study reported all the items listed in the PRISMA-A checklist. No high-quality evidence with GRADE assessment was found. With the low-quality evidence, acupuncture combined with other interventions was superior to monotherapy (medications or Chinese medicine) in the angina symptom and electrocardiogram recovery. No adverse effects owing to acupuncture were reported. Conclusions: Owing to the lack of high-quality evidence provided by the current SRs/MAs, the effective-ness of acupuncture for AP still warrants further proof. Further researches with more critical design and methodology are needed for providing more convincing evidence. Background: The number of systematic reviews or meta-analyses (SRs/MAs) on the effectiveness of acupuncture for angina pectoris (AP) is increasing. Due to the inconsistent conclusions and unknown quality of these SRs/MAs, this overview aimed to systematically evaluate and synthesize the existing SRs/MAs, attempting to provide more reliable evidence for the effectiveness and safety of acupuncture in the treatment of AP. Methods: SRs/MAs were searched via eight databases from inception to March 14, 2022. The risk of bias was evaluated using the Risk of Bias in Systematic reviews (ROBIS) tool. The quality of the methodology, reporting, and evidence were assessed by the Assess Systematic Reviews 2 (AMSTAR-2), the Preferred Reporting Item for Systematic Review and Meta-analysis for Acupuncture (PRISMA-A), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system, respectively. Results: Sixteen SRs/MAs were included and fifteen SRs/MAs were considered being of critically low quality according to AMSTAR-2. Only three SRs/MAs were rated at low risk of bias. No study reported all the items listed in the PRISMA-A checklist. No high-quality evidence with GRADE assessment was found. With the low-quality evidence, acupuncture combined with other interventions was superior to monotherapy (medications or Chinese medicine) in the angina symptom and electrocardiogram recovery. No adverse effects owing to acupuncture were reported. Conclusions: Owing to the lack of high-quality evidence provided by the current SRs/MAs, the effective-ness of acupuncture for AP still warrants further proof. Further researches with more critical design and methodology are needed for providing more convincing evidence.

圖們江開發中韓國的作用及投資新動向

戚文榮 明知大學校 經濟硏究所 2002 경영연구 Vol.21 No.2

圖們江開發이有10餘載,進入90年代以後,在UNDP和國際社會的支持與各個相美國家的協作下東北亞 經濟協作與圖們江開發事業的硏究與實踐邁入了新的發展階段,形成了國際經際開發合作的新問面. 經過10多年的調査硏究與廣泛的硏討活動,位干北朝鮮,中國,俄羅斯三國國界的圖們江流域的地理優勢得到了各國學者和企業家們的充分肯定, 韓國參與圖們江開發事業的目的可以說有兩個方面:一個是因爲圖們江地區的經濟潛力非常大,是推進?個東北亞經濟合作的重要一環. 煥句話說,通過參與這個未曾開發過的地區的開發.不僅擴大韓國企業的投資機會,還可以把사當作長期與中國,俄羅斯,以及與歐洲進行經濟交流的橋梁. 而且,利用羅津,先峰地區的地理,政治優勢使其成爲國際特區貿易的中心,這從投資的角度考慮也是흔有價値的一件事情, 령外一個시通過這個地區的多邊經濟開發事業,可以促進南北韓間的接觸及經濟交流,促使北朝鮮進行實驗性的開放. 作好最終統一準備,還可以通過多邊途徑打開南北韓之間經濟接觸的窓口,創造經濟合作的機會.

Recent advances of bioactive proteins/polypeptides in the treatment of breast cancer

Qi-Zhang Li,Ze-Rong Zhou,Cui-Yu Hu,Xian-Bin Li,Yu-Zhou Chang,Yan Liu,Yu-Liang Wang,Xuan-Wei Zhou 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.3

Proteins do not only serve as nutrients to fulfill the demand for food, but also are used as a source of bioactive proteins/polypeptides for regulating physical functions and promoting physical health. Female breast cancer has the highest incidence in the world and is a serious threat to women’s health. Bioactive proteins/polypeptides exert strong anti-tumor effects and exhibit inhibition of multiple breast cancer cells. This review discussed the suppressing effects of bioactive proteins/polypeptides on breast cancer in vitro and in vivo, and their mechanisms of migration and invasion inhibition, apoptosis induction, and cell cycle arrest. This may contribute to providing a basis for the development of bioactive proteins/polypeptides for the treatment of breast cancer.