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최대하 운동에 의한 피로도가 외발서기자세 균형에 미치는 영향
김영록,안연준,박승규 대불대학교 2003 大佛大學校大學院 硏究論文集 Vol.2 No.1
Fatigue is affected motor control, coordination and balance. This study recognize whether affect some balance of one leg standing by fatigue that do submaximal and is happened after exercise. It serve to measures and do maximum, strength of exercise measures heart beat same number and calculated target heart beat same number when is stable with maximum heart beat same number. This time, 5 minutes measured a rest after trouble very in couch of heart beat same number when maximum heart beat same number is stable being '220-ages' (maximum heart beat same number-heart beat same number when is stable) target heart beat same number is 0.85. When is stable serving to measure one leg balance is change after maximum low class exercise after and exercise 10 minutes after and measured change of balance with each mean value. This time, target heart beat same number for maximum low class exercise used heart of balance used active-balance system. Such measured value plain received figure using SPSS.
흰쥐에서 키토올리고당의 장 생태와 지질 상태에 미치는 용량에 따른 효과
김연록(Yeon-Rok Kim),최영선(Young-Sun Choi) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.4
본 연구는 흰쥐에서 저분자량(1~3 kDa) 키토올리고당(chitooligosaccharide, COS)이 장내 미생물에 미치는 항균 활성과 지질 개선에 관한 용량-반응 효과를 조사하기 위하여 수행되었다. 4주령 된 Sprague-Dawley 수컷 32마리를 1주일 동안 사육 환경에 적응시킨 후 군당 8마리씩 4군으로 나누어서 고지방식이에 키토올리고당을 0%(대조식이), 0.5%, 2%, 5% 수준으로 첨가한 식이를 5주 동안 자유롭게 급여하였다. 실험식이 5주째에 장 통과시간을 측정하였고, 신선한 분변을 취하여 장내 균수를 측정하였으며, 희생 후 혈장지질, 간 지질, GPT 활성, 분변 지질을 측정하였다. 체중 증가량과 식이섭취량은 COS 5% 첨가군에서 유의하게 낮았다. 분변 중 bifidobacteria, lactobacilli, bacteroides, total anaerobes, total aerobes 수는 대조군, COS 0.5% 첨가군과 COS 2% 첨가군 사이에 차이가 없었으나, COS 5% 첨가군에서는 모두 유의하게 감소하였다. 혈장 총 콜레스테롤, HDL-C 및 LDL-C 농도는 군간 차이가 없었으나, 중성지방 농도는 COS 2% 첨가군과 COS 5% 첨가군에서 유의하게 낮았으며, 키토올리고당의 용량이 높아질수록 낮았다. 간 조직의 중성지방 농도는 COS 5% 첨가군에서 낮았으며, 반면에 분변의 콜레스테롤 및 중성지방 농도는 COS 5% 첨가군에서 높았으나 담즙산은 차이가 없었다. 결론적으로 저분자량(1~3 kDa) 키토올리고당을 5% 첨가한 식이는 흰쥐의 식이섭취량, 체중증가량, 혈장 중성지방을 낮추어 지질 개선효과를 보였고, 분변의 혐기성균 중에 bacteroides의 균수를 크게 감소시켰으며 bifidobacteria와 lactobacilli 균수도 억제함으로써 장 미생물생태 변화를 초래하였다. This study was carried out to investigate the dose-response of chitooligosaccharide (with a molecular weight of 1~3 kDa) on antimicrobial activity and lipid lowering functions in rats. Sprague-Dawley male rats were given experimental diets containing 0 (control), 0.5, 2, or 5% chitooligosaccharide (COS) for 5 weeks. Weight gain and food intake were significantly lower in rats fed 5% COS than control rats and rats fed 0.5 and 2% COS. The numbers of fecal bacteria, including bifidobacteria, lactobacilli, bacteroides, total anaerobes, and total aerobes, which reflect gut microbiota, were significantly decreased in rats fed 5% COS. Plasma triglyceride concentrations significantly decreased in a dose-dependent manner in rats fed 2% or 5% COS, while plasma total cholesterol was not significantly different among groups. The hepatic concentration of triglycerides was lower in rats fed 5% COS, and fecal triglycerides significantly increased in rats fed 5% COS. These results indicate that 5% COS supplementation in a diet may exert antimicrobial activity in vivo, and inhibit the proliferation of typical gut microbes, while lowering lipids.
Young Rok Do,Yunsuk Choi,Mi Hwa Heo,Jin Seok Kim,Jae-ho Yoon,Je-Hwan Lee,Joon Seong Park,Sang Kyun Sohn,Sung Hyun Kim,Sungnam Lim,정주섭,Deog-Yeon Jo,Hyeon Seok Eom,Hawk Kim,So Yeon Jeon,Jong-Ho Won,Hee 대한혈액학회 2022 Blood Research Vol.57 No.3
Background Gaucher disease (GD) is an autosomal recessive disorder characterized by excessive accumulation of glucosylceramide in multiple organs. This study was performed to determine the detection rate of GD in a selected patient population with unexplained splenomegaly in Korea. Methods This was a multicenter, observational study conducted at 18 sites in Korea between December 2016 and February 2020. Adult patients with unexplained splenomegaly were enrolled and tested for β-glucosidase enzyme activity on dried blood spots (DBS) and in peripheral blood leukocytes. Mutation analysis was performed if the test was positive or indeterminate for the enzyme assay. The primary endpoint was the percentage of patients with GD in patients with unexplained splenomegaly. Results A total of 352 patients were enrolled in this study (male patients, 199; mean age, 48.42 yr). Amongst them, 14.77% of patients had concomitant hepatomegaly. The most common sign related to GD was splenomegaly (100%), followed by thrombocytopenia (44.32%) and, anemia (40.91%). The β-glucosidase activity assay on DBS and peripheral leukocytes showed abnormal results in sixteen and six patients, respectively. Eight patients were tested for the mutation, seven of whom were negative and one patient showed a positive mutation analysis result. One female patient who presented with splenomegaly and thrombocytopenia was diagnosed with type 1 GD. The detection rate of GD was 0.2841% (exact 95% CI, 0.0072‒1.5726). Conclusion The detection rate of GD in probable high-risk patients in Korea was lower than expected. However, the role of hemato-oncologists is still important in the diagnosis of GD.
The Efficiency of Selecting Target Flower Traits at Early Seedling Stage for New Cut Rose Cultivars
Je Yeon Yeon,Min Ji Kim,Yeong Chan Shin,Gyeong Rok Yang,Wan Soon Kim 한국화훼학회 2021 화훼연구 Vol.29 No.3
To increase the selection efficiency for new cultivars in cut roses during breeding programs, phenotypes of seedlings in two cross combinations, C1 (Rosa hybrida ‘Yellow King’ x ‘Aladin’) and C2 (R. hybrida ‘Evelien’ x ‘Sunny Isle’), were investigated. Although most seedlings showed classic-type flower shapes, some (0.4% - 0.7%) had tomato-shaped flowers, especially at the young plant stage (6 months old). The variation in petal color was high, and pink and pink-mixed flowers were dominant, accounting for 72% in C1 and 76% in C2 at the mature plant stage (13-month-old plants). However, the seedlings had changes in the expression of petal color at different growth stages. The number of petals at the young plant stage had a strong positive correlation with those at the mature plant stage in C1 (r = 0.84***) and C2 (r = 0.73***). Sizes of flowers and petals increased with the growth of the seedlings, and their traits at the young plant stage had positive correlations with those at the mature plant stage in both C1 (r = 0.32***) and C2 (r = 0.39***). Prickle expression on stems was mostly in level 5 at the young plant stage and then dispersed to various classes at the mature plant stage, which increased the variation and coefficient of variation. To select seedlings for new cultivars through breeding processes, breeders should consider the growth stage for targeted traits.
( Ji Yeon Shin ),( Do Won Kim ),( Chun Wook Park ),( Seong Jun Seo ),( Young Lip Park ),( Jong Rok Lee ),( Moon Bum Kim ),( Kyu Han Kim ),( Young Suck Ro ),( Sang Hyun Cho ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.1
Background: Providing an educational program as part of a health care program for the management of atopic dermatitis (AD) patients has rapidly become popular. AD educational programs can be of benefit in measured outcomes for both dermatology specialists and patients. Objective: To determine the effects of programmed education delivered by dermatology specialists on the management and knowledge of AD, we assessed the effectiveness of patient/parental education at improving AD knowledge, and determined the usefulness of the education. Methods: The program consisted of five, 20-minutes sessions which were prepared, discussed, reviewed, and delivered by professors of dermatology. At the end of the program, AD knowledge was assessed using a standardized questionnaire. A total of 148 people were included. Fifty-eight patients/parents received the programmed education and the remaining 90 did not receive the programmed education. Results: The mean questionnaire scores from both groups were compared. Mean knowledge scores were significantly higher for those who received the education (p=0.00). We analyzed the knowledge score according to factors such as gender, education level, marital status, and occupation. The data indicated that education level influences the subjects` knowledge level of AD, but gender, occupation, and marital status do not. Conclusion: An educational program can be an effective tool to improve patient quality of life and treatment compliance by providing psychological support to the patients and their parents. (Ann Dermatol 26(1) 66∼72, 2014)