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RISS 인기검색어
- 검색키워드
- 저자 : Roberto Gómez (검색결과 4 건)
- 무료
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Evaluation of the effect of D-002, a mixture of beeswax alcohols, on osteoarthritis symptoms
Roberto Puente,José Illnait,Rosa Mas,Daisy Carbajal,Sarahí Mendoza,Julio César Fernández,Meilis Mesa,Rafael Gámez,Pablo Reyes 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.2
Background/Aims: Nonsteroidal anti-inflammatory drugs relieve osteoarthritis(OA) symptoms but cause adverse effects. D-002, a mixture of beeswax alcohols,is effective against experimental OA. A pilot study found that D-002 (50 mg/day)for 8 weeks improves OA symptoms. The aim of this study was to investigate theeffects of D-002 (50 to 100 mg/day) administered for 6 weeks on OA symptoms. Methods: Patients with OA symptoms were double-blindly randomized to D-002(50 mg) or placebo for 6 weeks. Symptoms were assessed by the Western Ontarioand McMaster Individual Osteoarthritis Index (WOMAC) and the visual analogscale (VAS) scores. Patients without symptom improvement at week 3 were titratedto two daily tablets. The primary outcome was the total WOMAC score. WOMACpain, joint stiffness and physical function scores, VAS score, and use of rescuemedications were secondary outcomes. Results: All randomized patients (n = 60) completed the study, and 23 experienceddose titration (two in the D-002 and 21 in the placebo groups). At study completion,D-002 reduced total WOMAC (65.4%), pain (54.9%), joint stiffness (76.8%), andphysical function (66.9%) WOMAC scores, and the VAS score (46.8%) versusplacebo. These reductions were significant beginning in the second week, andbecame enhanced during the trial. The use of rescue medication by the D-002(6/30) group was lower than that in the placebo (17/30) group. The treatment waswell tolerated. Seven patients (two in the D-002 and five in the placebo group)reported adverse events. Conclusions: These results indicate that D-002 (50 to 100 mg/day) for 6 weeksameliorated arthritic symptoms and was well tolerated.
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Optimum Criss Crossing Cables in Multi-span Cable-stayed Bridges using Genetic Algorithms
Hiram Arellano,Dante Tolentino,Roberto Gómez 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.2
A multi-objective optimization approach in order to find the optimal cable overlap length in multi-span cable-stayed bridges with criss-cross cables is presented. The multi-objective optimization is solved by considering three objectives: 1) the cost of the cable system, 2) the displacement at the top of the pylon and 3) the alternate live load on the bridge. An unconventional criss-cross cable system configuration in which cables criss-cross at the center of intermediate spans is used for a bridge with five spans and four pylons. Taking into account both the cable overlap length and the different occurrences of alternate live load, the set of optimal solutions was obtained by the use of genetic algorithms. Results indicate that the optimal cable overlap length corresponds to three criss-crossing cables that corresponds to 0.28 times the length of the central span. Research on multi-span cable-stayed bridges with criss-cross cables allows the analysis of another solution for the problem of stabilizing the displacement of intermediate pylons in this kind of bridge.
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RANS Simulation of Wind Loading on Vaulted Canopy Roofs
Edmundo Amaya-Gallardo,Adrián Pozos-Estrada,Roberto Gómez 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.12
The use of isolated vaulted canopy roofs (VCR) for schools, emerging shelters, sports and recreational centers, among others, is quite popular worldwide. However, the design of such structures to resist wind effects is usually a problem due to the scarce technical information available in the literature. As an alternative resource, in the present research, wind effects on this type of structures immersed in the atmospheric boundary layer (ABL) are studied numerically by using the 3D Reynolds averaged Navier Stokes (RANS) approach considering different aspect ratios and wind directions. Since wind tunnel testing information for these structures is limited, experimental results of a Gabled Canopy Roof (GCR) as well as some experimental results for VCR are used as a validation source for the numerical models. Based on this validation, the simulation results of the mean wind loads of VCR appear to be reasonably good. The numerical results are used to study the mean net-pressure coefficients (CPN) over the VCR models and to establish the theoretical bases for coding them. It was found that the CPN are very sensitive to the VCR curvature and wind direction (90°, 75°, and 60°), and to a less extent to the plan and elevation geometric ratios. Further, it was also found that the use of GCR CPN for the design of VCR, as is usually done in professional practice, could lead to important differences in the magnitude of pressure coefficients and pressure distribution regarding actual VCR CPN and its distribution. A detailed analysis of the CPN for VCRs is presented.
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Self-assembly study of type I collagen extracted from male Wistar Hannover rat tail tendons
Jeimmy González-Masís,Jorge M. Cubero-Sesin,Simón Guerrero,Sara González-Camacho,Yendry Regina Corrales-Ureña,Carlos Redondo-Gómez,José Roberto Vega-Baudrit,Rodolfo J. Gonzalez-Paz 한국생체재료학회 2020 생체재료학회지 Vol.24 No.4
Background: Collagen, the most abundant protein in the animal kingdom, represents a promising biomaterial for regenerative medicine applications due to its structural diversity and self-assembling complexity. Despite collagen’s widely known structural and functional features, the thermodynamics behind its fibrillogenic self-assembling process is still to be fully understood. In this work we report on a series of spectroscopic, mechanical, morphological and thermodynamic characterizations of high purity type I collagen (with a D-pattern of 65 nm) extracted from Wistar Hannover rat tail. Our herein reported results can be of help to elucidate differences in selfassembly states of proteins using ITC to improve the design of energy responsive and dynamic materials for applications in tissue engineering and regenerative medicine. Methods: Herein we report the systematic study on the self-assembling fibrillogenesis mechanism of type I collagen, we provide morphological and thermodynamic evidence associated to different self-assembly events using ITC titrations. We provide thorough characterization of the effect of pH, effect of salts and protein conformation on self-assembled collagen samples via several complementary biophysical techniques, including circular dichroism (CD), Fourier Transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), atomic force microscopy (AFM), scanning electron microscopy (SEM), dynamic mechanical thermal analysis (DMTA) and thermogravimetric analysis (TGA). Results: Emphasis was made on the use of isothermal titration calorimetry (ITC) for the thermodynamic monitoring of fibrillogenesis stages of the protein. An overall self-assembly enthalpy value of 3.27 ± 0.85 J/mol was found. Different stages of the self-assembly mechanism were identified, initial stages take place at pH values lower than the protein isoelectric point (pI), however, higher energy release events were recorded at collagen’s pI. Denatured collagen employed as a control exhibited higher energy absorption at its pI, suggesting different energy exchange mechanisms as a consequence of different aggregation routes.
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