p16 Expression as a Surrogate Marker for HPV Infection in Esophageal Squamous Cell Carcinoma can Predict Response to Neo-Adjuvant Chemotherapy

Kumar, Rajeev,Ghosh, Sankar Kumar,Verma, Akalesh Kumar,Talukdar, Anuradha,Deka, Monoj Kumar,Wagh, Mira,Bahar, H.M. Iqbal,Tapkire, Ritesh,Chakraborty, Kali Pankaj,Kannan, R. Ravi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

Background: Esophageal squamous cell carcinoma (ESCC) is a common cancer in the north east of India. The present study concerned the prevalence of human papilloma virus (HPV) in the ESCC in north eastern India and its impact on response to chemotherapy. Materials and Methods: p16 expression, a surrogate marker for HPV infection was assessed in 101 pre-treatment biopsies of locally advanced ESCC, reported from a comprehensive cancer centre in north east India, using immunohistochemistry. All patients received neo-adjuvant chemotherapy. Response was assessed clinically and histopathologically with attention to p16 expression. Results: p16 was expressed in 22% of ESCC (22 out of 101) and was more prevalent in patients who were more than 45 years of age (P=0.048). p16 positive tumors appeared more commonly in the upper 2/3 of the thoracic esophagus (18 in 22). Nine of the 22 (41%) p16 positive tumors achieved pathologic complete response following neo-adjuvant chemotherapy (P=0.008). There was a trend towards reduced mortality in this group (P=0.048). Some 9 of the 20 (45%) patients who achieved pathologic complete response were p16 positive. Conclusions: Expression of p16 in ESCC correlates with higher rate of pathologic complete remission in patients undergoing neo adjuvant chemotherapy and could be a predictive marker for response assessment.

Fifty Years of Cervical Myelopathy Research: Results from a Bibliometric Analysis

Kumar Vishal,Patel Sandeep,Sharma Siddhartha,Kumar Ritesh,Kaur Rishemjit 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.6

We performed bibliometric analysis of the research papers published on clinical cervical spondylotic myelopathy (CSM) in the last 50 years. We extracted bibliometric data from Scopus and PubMed from 1970 to 2020 pertaining to clinical studies of CSM. The predominant journals, top cited articles, authors, and countries were identified using performance analysis. Science mapping was also performed to reveal the emerging trends, and conceptual and social structures of the authors and countries. Bibliometrix R-package was deployed for the study. The total numbers of clinical studies available in PubMed and Scopus were 1,302 and 3,470, respectively. The most cited article was published by Hilibrand AS, as observed in Scopus. Regarding the conceptual structure of the research, two main research themes were identified, one involving symptomatology, scientific-scale-based objective evaluation of symptoms, and surgical removal of the offending culprit, while the other was based on patho-etiology, relevant diagnostic modalities, and the surgery commonly performed for CSM. In terms of emerging trends, in recent times there is an increasing trend of scale-based objective evaluations, along with investigations of advanced nonoperative management. The United States is the most productive country, whereas Canada tops the list for inter-country collaboration. The trend of research showed a shift toward noninvasive procedures.

Classical Relativistic Extension of Kanai's Frictional Lagrangian

Ritesh Kumar Dubey,K. Singh 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.12

Working in an arbitrary Lorentz frame, we address the question of formulating the covariant variational principle for classical, single-particle, dissipative, relativistic mechanics. First, within a Minkowskian geometry, the basic properties of the proper time and the covariant velocity u are recapitulated. Next, using a scalar function (x) and its negative derivatives ''s, we construct a covariant Lagrangian that generalizes the famous Bateman-Caldirola-Kanai Lagrangian of non- relativistic frictional mechanics. Finally, we propose a deterministic model for (involving the drag coecient A) whose explicit solution leads to relativistic damped Rayleigh motion in the rest frame of the medium.

Design of Wideband Inverted Sinc Shaped Monopole Antenna for Wireless Applications

Ritesh Kumar Badhai,Nisha Gupta 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.1

A novel wideband inverted Sinc shaped printed monopole antenna is proposed for wireless devices. The proposed configuration not only realizes the monopole antenna in compact form but also depicts good radiation characteristics for wideband operations. A detailed parametric study has been carried out for different size of the ground plane, feed gap and Sinc strip length. By selecting the proper dimensions of ground plane, feed gap and Sinc strip length, the broadband operation for the proposed design can be achieved and the obtained impedance bandwidth covers the 2855-5081 MHz band. The proposed monopole antenna provides a wide frequency band of about 56% for wireless operation. The peak gain and efficiency of the proposed antenna are 4.05 dBi and 92.20 % respectively. Finally a prototype model is developed for the most effective configuration and the simulated results are validated experimentally. It is seen that the proposed antenna occupies small area and is suitable for operation at radio navigation, space research, amateur radio, aviation, public safety mobile, fixed mobile and fixed satellite communication frequencies.

Microwave Assisted Energy Efficient Biodiesel Production from Crude Pongamia pinnata (L.) Oil Using Homogeneous Catalyst

Kumar, Ritesh,Sethy, A.K. Institute of Forest Science 2015 Journal of Forest Science Vol.31 No.1

Microwave assisted biodiesel production from crude Pongamia pinnata oil using homogeneous base catalyst (KOH) was unsuccessful because of considerable soap formation. Therefore, a two step process of biodiesel production from high free fatty acid (FFA) oil was investigated. In first step, crude P. pinnata oil was acid catalyzed using $H_2SO_4$ and acid value of oil was reduced to less than 4 mg KOH/g. Effect of sulfuric acid concentration, alcohol-oil molar ratio and microwave irradiation time on acid value of oil was studied. Result suggested that 1.5% $H_2SO_4$ (w/w), 6:1 methanol oil molar ratio and 3 min microwave irradiation time was sufficient to reduce the acid value of oil from 12 and 22 mg KOH/g to 2.9 and 3.9 mg/KOH/g, respectively. Oil obtained after pretreatment was subsequently used for microwave assisted alkali catalyzed transesterification. A higher biodiesel yield (99.0%) was achieved by adopting two step processes. Microwave energy efficiency during alkali catalyzed transesterification was also investigated. The results suggested a significant energy saving because of reduced reaction time under microwave heating.

Microwave Assisted Energy Efficient Biodiesel Production from Crude Pongamia pinnata (L.) Oil Using Homogeneous Catalyst

Ritesh Kumar,A. K. Sethy 강원대학교 산림과학연구소 2015 Journal of Forest Science Vol.31 No.1

Microwave assisted biodiesel production from crude Pongamia pinnata oil using homogeneous base catalyst (KOH) was unsuccessful because of considerable soap formation. Therefore, a two step process of biodiesel production from high free fatty acid (FFA) oil was investigated. In first step, crude P. pinnata oil was acid catalyzed using H2SO4 and acid value of oil was reduced to less than 4 mg KOH/g. Effect of sulfuric acid concentration, alcohol-oil molar ratio and microwave irradiation time on acid value of oil was studied. Result suggested that 1.5% H2SO4 (w/w), 6:1 methanol oil molar ratio and 3 min microwave irradiation time was sufficient to reduce the acid value of oil from 12 and 22 mg KOH/g to 2.9 and 3.9 mg/KOH/g, respectively. Oil obtained after pretreatment was subsequently used for microwave assisted alkali catalyzed transesterification. A higher biodiesel yield (99.0%) was achieved by adopting two step processes. Microwave energy efficiency during alkali catalyzed transesterification was also investigated. The results suggested a significant energy saving because of reduced reaction time under microwave heating.

Talipariti simile (Blume) Fryxell: a new record for Vietnam

Ritesh Kumar Choudhary,Do Thi Xuyen,Tran The Bach,박상홍,Do Van Hai,이유미,이중구 한국식물분류학회 2014 식물 분류학회지 Vol.44 No.1

Talipariti simile (Blume) Fryxell, Malvaceae is reported as new record from Vietnam. The plant can be differentiated from its allied species T. macrophyllum (Roxb. ex Hornem.) Fryxell in having glabrescent stems with purplish and smaller hairs, lanceolate-oblong and smaller stipules and ovoid capsules which are devoid of apicule or beaks. Taxonomic description, line drawing and color photographs have been provided to add to the species identification. Furthermore, comparison of the diagnostic characters between this species and the above mentioned related species is made.

On-Farm Diversity Assessment and Participatory Varietal Evaluation of Cold-Tolerant Rice in Mid-Hills of Nepal

Ritesh Kumar Yadav,Rita Gurung,Rajeev Dhakal,Achyut Raj Adhikari,Subash Gautam,크리슈나 하리 기미르,Bhuwon Ratna Sthapit 한국작물학회 2019 Journal of crop science and biotechnology Vol.22 No.5

Drawing upon consequentially growing food insecurity in mid-hills attributed to poor adoption levels inter alia inflicted by narrow range of locally adaptive farmer’s preferred cold tolerant rice varietal options in national agricultural system, the present study was undertaken. We conducted on farm diversity assessment of 60 high altitude rice genotypes from ex-situ and on farm employing un-replicated diversity block in 2015. Subsequently, we identified eight promising locally adaptive genotypes as candidate genotypes based on the inferences of diversity block trial and evaluated them through participatory variety selection (PVS) using randomized block design in 2016 under on-farm conditions. Our studies revealed marked diversity among the Nepalese cold-tolerant rice genotypes. The UPGMA cluster analysis categorized the 60 genotypes into six distinct clusters. Strong positive correlation between grain yield and plant height; panicle length; straw yield and strong negative correlation between grain yield and 1000-grain weight was detected. PCA suggested traits viz., plant height, panicle length, days to 50% heading, and grain yield to be principal discriminatory characteristics of the cold-tolerant rice. Seto Kattike, Naulo Dhan, and Borang were most promising and adaptive genotypes whose eminence were justifiably corroborated and validated by farmer’s overall evaluation. The most valued farmer’s selection criteria were grain and straw yield, earliness, disease resistance, and stem borer tolerance. The findings bolster employment of novel and proven participatory plant breeding approach using diversity kits and IRD kits to expand and promote varietal choice options for immediate benefits to the farmers and facilitate rapid varietal release and registration.

Floristic diversity assessment and vegetation analysis of Upper Siang district of eastern Himalaya in North East India

Ritesh Kumar Choudhary,Ramesh Chandra Srivastava,Arup Kumar Das,이중구 한국식물분류학회 2012 식물 분류학회지 Vol.42 No.3

Present paper is an outcome of a four-year floristic survey work carried out in Upper Siang district of eastern Himalayan region in India which is also recognized as one of the 39 known ‘Biodiversity Hot-Spots’ of the world. We present here with a vegetation analysis of this area along with a checklist of 1,003 taxa belonging to 110 families, 529 genera, 994 species, 1 subspecies and 8 varieties of the angiosperms. Besides, one new species, 3 new records to India and 82 endemic species were also recorded. The diversity of herbs and shrubs were found higher than the tree species. Orchidaceae was found the most dominant family followed by Poaceae and Fabaceae. Many threatened plants have also been reported from the area. However, rapid urbanization and Jhum cultivation are imposing direct threat to the natural vegetation. We suggest some conservation measures that could help protecting this natural heritage.

Optimization of InAlAs/InGaAs HEMT Performance for Microwave Frequency Applications and Reliability

Ritesh Gupta,Sandeep Kumar Aggarwal,Mridula Gupta,R.S.Gupta 대한전자공학회 2004 Journal of semiconductor technology and science Vol.4 No.3

In the present paper efforts have been made to optimize InALs/lnGaAs HEMT by enhancing the effective gate voltage (Vo-Voft) using pulsed doped structure from uniformly doped to delta doped for microwave frequency applications and reliability. The detailed design criteria to select the proper design parameters have also been discussed in detail to exclude parallel conduction without affecting the dewice performance. Then the optimized value of Vo-Voft and breakdown voltages corresponding to maximum value of transconductance has been obtained. These values are then used to predict the transconductance and cut-off frequency of the device for different channel depths and gate lengths.<br/> Index Terms-InAlAs/InGaAs heterostructure, delta doped, uniformly doped, pulsed doped, parallel conduction, channel confinement and breakdown, woltage<br/>