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The effect of age on motor deficits and cerebral glucose metabolism of Parkinson’s disease
Lee, M. S.,Lyoo, C. H.,Ryu, Y. H.,Lim, H. S.,Nam, C. M.,Kim, H. S.,Rinne, J. O. Blackwell Publishing Ltd 2011 Acta neurologica Scandinavica Vol.124 No.3
<P>Lee MS, Lyoo CH, Ryu YH, Lim HS, Nam CM, Kim HS, Rinne JO. The effect of age on motor deficits and cerebral glucose metabolism of Parkinson’s disease. Acta Neurol Scand: 2011: 124: 196–201. © 2010 John Wiley & Sons A/S.</P><P><B>Background – </B> No systematic study has been made to separate age‐related clinical deterioration and dysfunctional brain areas from those associated with Parkinson’s disease (PD).</P><P><B>Methods – </B> This study included 73 <I>de novo</I> patients with PD and 43 age‐matched controls. All subjects underwent [<SUP>18</SUP>F]‐fluorodeoxy glucose (FDG) positron emission tomography studies. The severity of parkinsonian motor deficit was measured using unified PD rating scale (UPDRS) motor scores. Multiple linear regression analysis was used to identify those parkinsonian motor deficits for which severity was correlated with the age of the patients and to locate brain areas in which normalized FDG uptake values were inversely correlated with the age of the subjects.</P><P><B>Results – </B> Patient age was positively correlated with total UPDRS motor scores and with subscores for bradykinesia and axial motor deficits, but not with subscores for tremor and rigidity. In the control group, an age‐related decline in glucose uptake was found only in the cingulate cortex. However, in the patient group, an inverse correlation between age and glucose uptake was observed in the prefrontal, cingulate, orbitofrontal, perisylvian areas, caudate, and thalamus.</P><P><B>Conclusions – </B> In PD, widespread age‐related decline in cerebral function may exaggerate the deterioration associated with bradykinesia and the axial motor deficits associated with nigral neuronal loss.</P>
Lyoo, Chul Hyoung,Aalto, Sargo,Rinne, Juha O,Lee, Ki Ook,Oh, Seung Hun,Chang, Jin Woo,Lee, Myung Sik Wiley Subscription Services, Inc., A Wiley Company 2007 Movement disorders Vol.22 No.15
<P>Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [<SUP>18</SUP>F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG. © 2007 Movement Disorder Society</P>
Suh, Uhi Rinn,Oh, Se-jin Academic Press 2019 Journal of algebra Vol.535 No.-
<P><B>Abstract</B></P> <P>In this paper, we introduce twisted and folded AR-quivers of type <SUB> A 2 n + 1 </SUB> , <SUB> D n + 1 </SUB> , <SUB> E 6 </SUB> and <SUB> D 4 </SUB> associated to (triply) twisted Coxeter elements. Using the quivers of type <SUB> A 2 n + 1 </SUB> and <SUB> D n + 1 </SUB> , we describe the denominator formulas and Dorey's rule for quantum affine algebras U q ′ ( B n + 1 ( 1 ) ) and U q ′ ( <SUB> <SUP> C ( 1 ) </SUP> n </SUB> ) , which are important information of representation theory of quantum affine algebras. More precisely, we can read the denominator formulas for U q ′ ( B n + 1 ( 1 ) ) (resp. U q ′ ( C n ( 1 ) ) ) using certain statistics on any folded AR-quiver of type <SUB> A 2 n + 1 </SUB> (resp. <SUB> D n + 1 </SUB> ) and Dorey's rule for U q ′ ( B n + 1 ( 1 ) ) (resp. U q ′ ( C n ( 1 ) ) ) applying the notion of minimal pairs in a twisted AR-quiver. By adopting the same arguments, we propose the conjectural denominator formulas and Dorey's rule for U q ′ ( F 4 ( 1 ) ) and U q ′ ( G 2 ( 1 ) ) .</P>
임상판단모델에 근거한 간호대학생의 임상적 판단 분석 : 자간전증 시뮬레이션을 중심으로
김아린 청주대학교 보건의료과학연구소 2015 보건의료과학연구 Vol.4 No.1
This study was performed to evaluate the way in which nursing student made clinical judgment in the preeclampsia simulation using high fidelity simulator. The data were collected November 10 to 19, 2014. The student’s clinical judgement skills were analyzed using clinical performance indicators of 20 simulation teams and the reflective narratives of 84 nursing students according to noticing, interpreting, responding, and reflection. The data were analyzed descriptive statistics based on Tanner’s clinical judgement model. The most of students were performed well focus observation to find cues that implied the patient condition. However, some students had difficult in interpreting the meaning of the data and determining appropriate action. To develop clinical judgement for nursing students, the nursing educators need to consider repeated simulation training that enhance interpreting and responding process using Tanner’s model.
COMBINATORIAL AUSLANDER-REITEN QUIVERS AND REDUCED EXPRESSIONS
Oh, Se-jin,Suh, Uhi Rinn Korean Mathematical Society 2019 대한수학회지 Vol.56 No.2
In this paper, we introduce the notion of combinatorial Auslander-Reiten (AR) quivers for commutation classes [${\tilde{w}}]$ of w in a finite Weyl group. This combinatorial object is the Hasse diagram of the convex partial order ${\prec}_{[{\tilde{w}}]}$ on the subset ${\Phi}(w)$ of positive roots. By analyzing properties of the combinatorial AR-quivers with labelings and reflection functors, we can apply their properties to the representation theory of KLR algebras and dual PBW-basis associated to any commutation class [${\tilde{w}}_0$] of the longest element $w_0$ of any finite type.
어머니의 양육행동이 청소년의 인터넷 중독에 영향을 미치는 경로
김민정(Min Jung Kim),박보경(Bo Kyung Park),이혜린(Hye Rinn Lee),도현심(Hyun Sim Doh) 한국아동학회 2009 아동학회지 Vol.30 No.2
This study examined pathways from maternal parenting behavior to adolescents' internet addiction through both self-control and depression/anxiety. Participants were 449 8th and 9th graders in Seoul. They completed questionnaires on maternal parenting behavior, adolescents' self-control, depression/anxiety, and internet addiction. Data were analyzed by structural equation modeling. Maternal parenting behavior indirectly influenced adolescents' internet addiction through self-control and depression/anxiety. Self-control and depression/anxiety individually mediated between maternal parenting behavior and internet addition. However, maternal parenting behavior didn't directly affect adolescents' internet addiction. Self-control was influenced by maternal parenting behavior and also played a crucial role in preventing adolescents' internet addiction.