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Ricardo Ernesto Ramírez-Orozco,Elena Franco Robles,Victoriano Pérez Vázquez,Joel Ramírez Emiliano,Marco Antonio Hernández Luna,Sergio López Briones 한국미생물학회 2018 The journal of microbiology Vol.56 No.9
Obesity is a chronic disease associated with different metabolic diseases as well as alterations in immune cell function. It is characterized by a chronic systemic low grade inflammation. There are several studies demonstrating the influence of obesity on the impaired immune response to infection. However, it is not completely clear whether the obese environment influences the development or maintenance of the immune response against infections. The aim of this study was to determine how obesity induced by a high-fat diet affects the immune response to an early oral Salmonella infection. Four groups of mice were kept in separate cages. Two of these designated as controls, fed with a normal diet; whereas other two groups were fed with a high fat diet for 10 weeks. Some mice were used for Salmonella oral infection. After 7 days of oral infection with S. Thypimurium the proportions of spleen cell subsets expressing activation markers in normal diet and HFD obese mice were stained with monoclonal antibodies and analyzed by flow cytometry. Also, mRNA levels of different cytokines were quantified by RT-PCR. It was found that obesity affects the function of the immune system against an early oral Salmonella infection, decreasing NK cells, altering the expression of activation molecules as well as cytokines mRNA levels. Interestingly, the expression some activation molecules on T lymphocytes was reestablished after Salmonella infection, but not the CD25 expression. Immune alterations could lead to immunosuppression or increased susceptibility to infections in HFD obese mice.
( Roberto Monreal Robles ),( Hugo L Gallardo Blanco ),( Fernando J Lavalle Gonzalez ),( Ricardo M Cerda Flores ),( Pavel Carrillo Molina ),( Minerva G Martinez Cavazos ),( Laura E Martinez Garza ),( J 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Currently there are a growing number of individuals with type 2 diabetes (T2D) imposing a signifi cant public health burden due to disability and premature death. Diabetes is the most common cause of death in Mexico. It is estimated that 11.7 million Mexicans will have diabetes by the year 2025. The risk of developing T2D is determined by genetic and environmental factors. However, large differences in prevalence between ethnic groups exist and seem to depend on genetic factors. Nearly 40 different T2D susceptibility loci, mainly in Europeans have been identifi ed. The aim of this study was to identify susceptibility loci related to T2D in our population. Methods: We studied 128 SNPs in or near 42 genes, most of which had been replicated in other populations. A case-control association study comprising 186 controls, 211 early-onset T2D (diagnosed before 45 years of age) and 173 late-onset T2D individuals was conducted. Actually we preliminary reported the genotypifi cation analyses of 256 individuals. Results: Subjects with T2D independently of age at diagnosis have higher mass body index than controls (27.5 vs 25.7 kg/m2, P= <0.0001). The median age for early-onset T2D, late-onset T2D and controls individuals were 46, 61 and 62 years, respectively. Age at diagnosis for early-onset and late-onset T2D individuals was 35 and 52 years, respectively. The allelic variants of genes KCNJ11 (rs5219), LEPR (rs11208654), IGF2BP2 (rs4402960), VLDLR (rs2242103), KCNQ1 (rs2237892), RPTOR (rs12946115), SLC25A18 (rs1296819) show association with T2D in this preliminary analysis. These polymorphism previously mentioned affect directly or indirectly over insulin release and peripheral sensitivity. Conclusions: We found our population to have an important genetic predisposition to T2D. The associated susceptibility loci for T2D support the hypothesis that insulin release defects and peripheral resistance are the main mechanisms predisposing to T2D in Mexican population.
Adriana Saldana-Robles,Juan M. Peralta-Hernandez,Ricardo Guerra-Sanchez,Manuel I. Maldonado-Rubio 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.3
This study focused on the application of RSM on the Fenton process and the adsorption of vegetal carbon(VC) to obtain the optimal conditions for the minimization of the colored synthetic wastewater. Methylorange (MO) with an azo dye was used as the model organic compound. Fenton processes wereinvestigated to establish the optimal conditions. The Fe2+/H2O2 ratio was studied to establish the majorMO degradation when 100 and 200 mg/L of MO were treated. For the adsorption process, to determinethe optimal conditions, the principal variables studied were the vegetal carbon mass dosage, degradationtime and dye concentration.
Victor Lopez-Lopez,Yusuke Ome,Yusuke Kawamoto,Alvaro Gómez Ruiz,Ricardo Robles Campos,Goro Honda 대한내시경복강경외과학회 2020 Journal of Minimally Invasive Surgery Vol.23 No.1
Since the beginning of laparoscopic liver surgery, resection of the posterosuperior segments has been considered one of the most challenging procedure due to its difficult access. The main drawbacks of the laparoscopic approach to dome lesions are poor visualization, the difficulty of instrumentation and the greater complexity in the control of bleeding. In the evolution of minimally invasive techniques from hybrid techniques to the current purely laparoscopic approaches, the different authors have established gradually the currents indications and surgical techniques to operate these segments with a similar feasibility and safety than open approach. The standardization in the patient position, the use of intercostal trocars, the learning curve in laparoscopic liver surgery, the management of the hepatic blood flow and the refinement of the technique in the extrahepatic and intrahepatic Glissonean pedicle approaches, has allowed to leave behind the initial contraindications about the laparoscopic approach in these segments. In the present review of the literature, the accumulated experience of the different groups in minimally invasive liver surgery together with the technological advances in the different laparoscopic devices have facilitated the resection of tumors in segments 7 and 8 with similar and even better results than open surgery.
Clinical significance of PIVKA-II levels after liver transplantation for hepatocellular carcinoma
Felipe ALCONCHEL,Francisco VILLALBA,Luis SAENZ,Maria Isabel SANCHEZ,David FERRERAS,Pedro CASCALES,Ricardo ROBLES,Francisco SANCHEZ-BUENO,Pablo RAMIREZ 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-