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중앙유치원 『표정유희창가집』의 음악적 특성에 관한 연구
박헤리나(He Ri Na Park) 한국영유아교원교육학회 2013 幼兒 敎育學論集 Vol.17 No.1
본 연구는 현 중앙대학교 사범대학 부속유치원의 전신인 중앙유치원의 음악교재, 『표정유희창가집』제 2집에 수록된 한국 작곡가 곡들의 음악적 특성을 분석해 보는데 목적이 있다. 이 책에는 총 66곡이 수록되어 있는데 그 중 8곡이 한국 작곡가의 작품이다. 그동안 선행연구에서 이 곡들이 일본의 군가와 흡사한 곡으로 평가되고 있어 이를 밝히고자 본 연구의 대상으로 선택하였다. 곡의 형식, 리듬, 음계, 선율구성 등을 중심으로 분석한 결과 한국작곡가의 작품은 물론이거니와 일본인이 작곡한 곡까지도 일본 창가 풍의 곡이 아니었음을 알 수 있었다. 그리고 음악적 특징뿐만 아니라 일제의 탄압을 받으면서도 타 유치원과 달리 중앙유치원에서는 한국어로 된 노래를 가르쳤다는 사실에서 중앙유치원은 유희창가교육을 통해 민족의식을 고취시킨 유치원이었다는 점도 알 수 있었다. This study is to identify the musical characteristics of the songs composed by Korean composers that are included in the second volume of "PyoJeongyoohee Chang-ga." collaborated by Cha, Sabaek and Lee, Youngbo. In addition, it is the music textbook of Chung-Ang kindergarten, the former Kindergarten attached to College of Education of Chung-Ang University. Eight of 66 songs included in this book were composed by Korean composers. As a result of the musical analysis, it was found that the songs composed by Japanese composers as well as the songs composed by Korean composers are not Japanese Chang-ga style. It also implies that Chung-Ang Kindergarten made an effort to establish children`s kindergarten songs because they sang songs not in Japanese but in Korean at the time of Japanese colonial oppression. It is also meaningful in the modern kindergarten education that children were educated with the songs composed by Koreans that other kindergartens refused to teach.
Tang Ri,Tang Ri,Xu Qiaoyi,Feng Jinhua,Zhou Yang,Xing Shunpeng,He Zhengyu,Gao Yuan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Recent clinical research has revealed that mechanical ventilation (MV) can initiate pulmonary fibrosis and induce mechanical ventilation-induced pulmonary fibrosis (MVPF). However, the underlying mechanism remains largely uncharacterized. Based on a mouse model of MVPF and an alveolar epithelial cell cyclic strain model, the present study explores the possible mechanism of MVPF. Single-cell RNA-sequencing and EV RNA-sequencing analysis revealed that MV promoted apoptosis signal-regulating kinase 1 (ASK1)-mediated endoplasmic reticulum (ER) stress pathway activation and extracellular vesicle (EV) release from alveolar epithelial cells. Furthermore, the ASK1-ER stress pathway was shown to mediate mechanical stretch (MS)- or MV-induced EV release and lung fibroblast activation in vivo and in vitro. These processes were suppressed by ER stress inhibitors or by silencing ASK1 with ASK1- short hairpin RNA (shRNA). In addition, MVPF was suppressed by inhibiting ASK1 and ER stress in vivo. Therefore, the present study demonstrates that ASK1-ER stress pathway-mediated fibrotic-EV release from alveolar epithelial cells contributes to fibroblast activation and the initiation of pulmonary fibrosis during MV. The inhibited release of EVs targeting the ASK1-ER stress pathway might be a promising treatment strategy for MVPF.
He, Jin,Kim, Jae Ri,Lee, Seung Yeoun,Oh, Jinseok,Park, Taesung,Kang, Mee Joo,Kwon, Wooil,Kim, Hongbeom,Kim, Sun-Whe,Cameron, John L.,Wolfgang, Christopher L.,Jang, Jin-Young Wiley (John WileySons) 2017 Journal of hepato-biliary-pancreatic sciences Vol.24 No.8
<P>Conclusion This new staging system has better discriminatory ability in stratifying 5-year OS rates based on a large multinational database.</P>
Inhibition of Breast Cancer Metastasis Via PITPNM3 by Pachymic Acid
Hong, Ri,Shen, Min-He,Xie, Xiao-Hong,Ruan, Shan-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets of breast tumor cells is an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. In addition, we found that pachymic acid (PA) could dose-dependently inhibit migration and invasion of MDA-MB-231cells, with or without rCCL18 stimulation. Furthermore, evidence was obtained that PA could suppress the phosphorylation of PITPNM3 and the combination of CCL18 and PITPNM3. Therefore, we speculate that PA could inhibit breast cancer metastasis via PITPNM3.
Hao Cui,He-Chun Quan,Ri Jin,Zhehao Lin 대한토목학회 2023 KSCE JOURNAL OF CIVIL ENGINEERING Vol.27 No.1
Flood susceptibility mapping is an important method for flood research. In this paper, we combine a backpropagation neural network (BPNN) with a genetic quantum algorithm (GQA) for the first time to develop flood susceptibility mapping. The area on the Chinese side of the Tumen River Basin was selected as the research object. A set of flood conditioning factors was selected based on relevant literature and an actual situation and then validated using the chi-square test and correlation analysis. Different weights were assigned using stepwise weight assessment ratio analysis. Finally, modeling and flood susceptibility mapping using GQA-BPNN. As a reference, the same work was performed with both the pure BPNN and optimized BPNN using a genetic algorithm (GA). The results show that the area under the curve, root mean squared error, Nash-Sutcliffe coefficient and percentage of bias are significantly better for the GQA-BPNN than for the BPNN and GA-BPNN and that the flood sensitivity maps constructed by the GQA-BPNN have more flood points in high flood sensitivity areas. Therefore, the GQA-BPNN method can be considered an effective method for flood susceptibility mapping.
Directed Evolution of Beta-galactosidase from Escherichia coli into Beta-glucuronidase
Xiong, Ai-Sheng,Peng, Ri-He,Zhuang, Jing,Liu, Jin-Ge,Xu, Fang,Cai, Bin,Guo, Zhao-Kui,Qiao, Yu-Shan,Chen, Jian-Min,Zhang, Zhen,Yao, Quan-Hong Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.3
In vitro directed evolution through DNA shuffling is a powerful molecular tool for creation of new biological phenotypes. E. coli $\beta$-galactosidase and $\beta$-glucuronidase are widely used, and their biological function, catalytic mechanism, and molecular structures are well characterized. We applied an in vitro directed evolution strategy through DNA shuffling and obtained five mutants named YG6764, YG6768, YG6769, YG6770 and YG6771 after two rounds of DNA shuffling and screening, which exhibited more $\beta$-glucuronidase activity than wild-type $\beta$-galactosidase. These variants had mutations at fourteen nucleic acid sites, resulting in changes in ten amino acids: S193N, T266A, Q267R, V411A, D448G, G466A, L527I, M543I, Q626R and Q951R. We expressed and purified those mutant proteins. Compared to the wild-type protein, five mutant proteins exhibited high $\beta$-glucuronidase activity. The comparison of molecular models of the mutated and wildtype enzymes revealed the relationship between protein function and structural modification.