Assessment of Relationship between Wilms' Tumor Gene (WT1) Expression in Peripheral Blood of Acute Leukemia Patients and Serum IL-12 and C3 Levels

Rezai, Omran,Khodadadi, Ali,Heike, Yuji,Mostafai, Ali,Gerdabi, Nader Dashti,Rashno, Mohammad,Abdoli, Zahra Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

Background: Leukemia is a common cancer among children and adolescents. Wilms' tumor gene (WT1) is highly expressed in patients with acute leukemia. It is found as a tumor associated antigen (TAA) in various types of hematopoietic malignancies and can be employed as a useful marker for targeted immunotherapy and monitoring of minimal residual disease (MRD). In this regard, WT1 is a transcription factor that promotes gene activation or repression depending on cellular and promoter context. The purpose of this study was assessment of WT1 gene expression in patients with acute leukemia, measurement of IL-12 and C3 levels in serum and evaluation of the relationship between them. Materials and Methods: We evaluated the expression of WT1 mRNA using real-time quantitative RT-PCR and serum levels of IL-12 and C3 using ELISA and nephelometry in peripheral blood of 12 newly diagnosed patients with acute leukemia and 12 controls. Results: The results of our study showed that the average wT1 gene expression in patients was 7.7 times higher than in healthy controls (P <0.05). In addition, IL-12 (P = 0.003) and C3 (P <0.0001) were significantly decreased in the test group compared to controls. Conclusions: WT1 expression levels are significantly higher in patients compared with control subjects whereas serum levels of interleukin-12 and C3 are significantly lower in patients. Wt1 expression levels in patients are inversely related with serum levels of IL-12 and C3.

Solution of combined economic and emission dispatch problem using a novel chaotic improved harmony search algorithm

Hamid Rezaie,M.H. Kazemi-Rahbar,Behrooz Vahidi,Hasan Rastegar 한국CDE학회 2019 Journal of computational design and engineering Vol.6 No.3

This paper presents a new optimization technique developed based on harmony search algorithm (HSA), called chaotic improved harmony search algorithm (CIHSA). In the proposed algorithm, the original HSA is improved using several innovative modifications in the optimization procedure such as using chaotic patterns instead of uniform distribution to generate random numbers, dynamically tuning the algorithm parameters, and employing virtual harmony memories. Also, a novel type of local optimization is intro-duced and employed in the algorithm procedure. Applying these modifications to HSA has resulted in enhancing the robustness, accuracy and search efficiency of the algorithm, and significantly reducing the iterations number required to achieve the optimal solution. To validate the effectiveness of CIHSA, it is used to solve the combined economic emission dispatch (CEED) problem, which practically is a com-plex high-dimensional non-convex optimization task with several equality and inequality constraints. Six test systems having 6, 10, 13, 14, 40, and 140 generators are investigated in this study, and the valve-point loading effects, ramp rate limits and power transmission losses are also taken into account. The results obtained by CIHSA are compared with the results reported in a large number of other research works. Furthermore, the statistical data regarding the CIHSA performance in all test systems is presented. The numerical and statistical results confirm the high quality of the solutions found by CIHSA and its superiority compared to other existing techniques employed in solving CEED problems.

A New Left-to-Right Scalar Multiplication Algorithm Using a New Recoding Technique

Abdalhossein Rezai,Parviz Keshavarzi 보안공학연구지원센터 2014 International Journal of Security and Its Applicat Vol.8 No.3

Effect of Light Intensity on Leaf Morphology, Photosynthetic Capacity, and Chlorophyll Content in Sage (Salvia officinalis L.)

Sedigheh Rezai,Nematollah Etemadi 한국원예학회 2018 원예과학기술지 Vol.36 No.1

Sage (Salvia officinalis) has been an important medicinal plant since antiquity. Here, we aimed todetermine the optimum light intensity for S. officinalis growth by quantifying the effects of differentshade treatments on plant morphology, chlorophyll and carotenoid content, and photosyntheticcapacity in a semi-arid region of Iran. Plants were grown for 5 months under full sunlight (0%shade) as well as 30%, 50%, or 70% shade levels by applying different shade treatments. While leafsize was greatest under 50% shade level, leaves of seedlings grown under full sunlight weresmallest. Leaf color under both 50% and 70% shade levels was yellowish-green. The highestphotosynthesis activity was achieved under full sunlight. Decreasing light intensity led to anincrease in chlorophyll and carotenoid content. Shade levels above 30% limited carbon assimilationand led to decreased essential oil content and plant growth. In conclusion, 30% shade is suggestedto be an optimum light irradiance for the cultivation of S. officinalis.

The effect of lipopolysaccharide from uropathogenic Escherichia coli on the immune system, testis tissue, and spermatozoa of BALB/c mice

Khadije Rezai Khanmohammad,Mohammad Bagher Khalili,Maryam Sadeh,Talebi Ali Reza,Akram Astani,Ali Shams,Fateme Zare 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.2

Objective: Uropathogenic Escherichia coli is known to cause urinary tract infections, and the endotoxin (lipopolysaccharide [LPS]) of this bacterium may cause deficiencies of sperm quality and morphology. In the present study, the effects of LPS on mouse sperm were studied, and the levels of interleukin (IL)-17A and possible changes in testis tissue were evaluated.Methods: LPS of uropathogenic E. coli was extracted using the methanol-chloroform method, followed confirmation using sodium dodecyl sulfate-polyacrylamide electrophoresis. Purified LPS (100 µg/kg) or phosphate-buffered saline was injected intraperitoneally into BALB/c mice for 7 days consecutively in the test and control groups, Mice were sacrificed on days 3, 7, and 42 after the first injection. Blood was tested for levels of IL-17A using the enzyme-linked immunosorbent assay method. Testis tissue and sperm were collected from each mouse and were studied according to standard protocols. Results: The mean sperm count and motility significantly decreased (p=0.03) at 3, 7, and 42 days after the injections. The level of IL-17A in the test groups increased, but not significantly (p=0.8, p=0.11, and p=0.15, respectively). Microscopic studies showed no obvious changes in the morphology of the testis tissue; however, significant changes were observed in the cellular parenchyma on day 42. Conclusion: LPS can stimulate the immune system to produce pro-inflammatory cytokines, resulting in an immune response in the testis and ultimately leading to deficiency in sperm parameters and testis tissue damage. In addition, the presence of LPS could significantly impair sperm parameters, as shown by the finding of decreased motility.

Estimating Tuberculin Skin Test Reactions among Children and Teenagers Who Received the Bacillus Calmette-Guerin Vaccination at Birth: A Meta-analysis

Mohammad Sadegh Rezai,Siavosh Abedi,Mahdi Afshari,Mahmood Moosazadeh 질병관리본부 2017 Osong Public Health and Research Persptectives Vol.8 No.1

Objectives: Tuberculin skin reaction size is one indicator of bacillus Calmette-Guérin (BCG) vaccine efficacy and a way to diagnose latent infection. Several primary studies have examined this issue. Combining the results of these studies using a meta-analysis will provide reliable evidence regarding this indicator for policymakers. This study aimed to estimate the total frequency of different tuberculin skin test reactions among Iranian children and teenagers who received the BCG vaccination at birth. Methods: National and international databanks were searched using relevant keywords. After the search strategy was restricted and duplicates were excluded, the titles and abstracts of the remaining papers were screened. All included studies included healthy children who received the BCG vaccine without confirmed tuberculosis exposure. Heterogeneity of the results was assessed using the Cochrane test and I2 index showed the random effects model as the best model for estimating the pooled results. Results: We combined the results of 14 primary studies including purified protein derivative reaction test measures of 26,281 Iranian children. The frequencies (95% confidence intervals) of the reactions were 8.5% (6.2–10.8) for patients with a reaction size ≥ 10 mm, 29.9% (22.3–37.4) for a reaction size of 5–9 mm, and 60% (48.9–71.1) for a reaction size < 5 mm. Conclusion: Our study showed that large numbers of Iranian children and teens have no positive BCG vaccine reaction and a considerable number of children have been exposed to Mycobacterium tuberculosis.

An evaluation on sol-gel chemical processing of refractory barium hexa aluminate fibrous structures

H.R. Rezaie,R. Naghizadeh,F. Arianpour,R. Ghasemzadeh,S. Eslami 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.2

In this research barium hexa aluminate fibrous refractory products were produced by a chemical processing route. Boehmite was used as aluminum precursor while barium nitrate was used as barium precursor and the final solution had made according to stoichiometric BaO.6Al2O3 composition. It was found that two different gels could be obtained during this route. Mainly the secondary gel was trapped into the initial gel structure. Finally gels were heated at various temperatures (1350, 1650℃) to following the formation of the barium hexa aluminate in fibrous structure due to sintering. Then the crystallization of transitional phases such as 3BaO.Al2O3 and BaO.Al2O3 to BaO.6Al2O3 were followed at different sintering temperatures by X-ray diffractometry (XRD) and Fourier transform infrared (FTIR) spectroscopy. Also scanning electron microscopy (SEM) was used to study the microstructural changes and micrographies. The produced gels were characterized by thermo gravimetrical and differential thermal analysis (TG/DTA). The results showed that BaO.6Al2O3 was the major phase at higher temperatures and fibrous structure appeared in final samples. In this research barium hexa aluminate fibrous refractory products were produced by a chemical processing route. Boehmite was used as aluminum precursor while barium nitrate was used as barium precursor and the final solution had made according to stoichiometric BaO.6Al2O3 composition. It was found that two different gels could be obtained during this route. Mainly the secondary gel was trapped into the initial gel structure. Finally gels were heated at various temperatures (1350, 1650℃) to following the formation of the barium hexa aluminate in fibrous structure due to sintering. Then the crystallization of transitional phases such as 3BaO.Al2O3 and BaO.Al2O3 to BaO.6Al2O3 were followed at different sintering temperatures by X-ray diffractometry (XRD) and Fourier transform infrared (FTIR) spectroscopy. Also scanning electron microscopy (SEM) was used to study the microstructural changes and micrographies. The produced gels were characterized by thermo gravimetrical and differential thermal analysis (TG/DTA). The results showed that BaO.6Al2O3 was the major phase at higher temperatures and fibrous structure appeared in final samples.

Surface Functionalization of Polyester Fibers via One-step Green Formation and Assembling of Iron Oxide Nanoparticles with Photo and Magneto Activities

Ali Bashiri Rezaie,Majid Montazer 한국섬유공학회 2019 Fibers and polymers Vol.20 No.5

In this research for the first time, surface functionalization of polyester fibers was performed via one-step, facileand clean strategy through green synthesis and deposition of iron oxide nanoparticles for photocatalytic and magneticapplications. The commercial ash of Seidlitzia Rosmarinus plant was used as a natural alkaline source for nanoparticlessynthesis as well as surface modification of polyester substrate and iron sulfate as metal precursor. The presence of iron oxidenanoparticles on polyester fibers was proved by X-ray diffraction analysis, energy-dispersive X-ray spectroscopy, mapping,field-emission scanning electron microscope images and Fourier transform infrared spectra. The fabricated samples exhibitedvery good photocatalytic activities toward methylene blue decoloration about 95.45 % after 48 h exposing to sunlightirradiation. In addition, they indicated appropriate magnetic properties with saturated magnetization of 2.30 and 1.69 emu/gat room temperature. The coloring effect, weight change and wettability behavior of the fabricated samples were alsoinvestigated. The mentioned route in this paper can simply be scaled up as an eco-friendly and scalable route for surfacefunctionalization of polymeric substrates via synthesis and deposition of iron oxide nanoparticles to acquire durable photoand magneto activities on polymers for different applications.

Investigation of hydrothermal synthesis of wollastonite using silica and nano silica at different pressuresV

Hamid Reza Rezaie,Arash Yazdani,Hossein Ghassai 한양대학교 세라믹연구소 2010 Journal of Ceramic Processing Research Vol.11 No.3

In this research a hydrothermal method was applied to synthesis of wollastonite. Silica, nano silica and calcium carbonate were used as raw materials. Different slurries were prepared with SiO2/CaO molar ratios of 0.54, 0.8, 1 and a solid content of 50 wt%. Then the slurries were hydrothermally treated in an autoclave for 2 h at 200 oC at pressures of 3, 5 and 7 atm. In the next step, the samples were dried at 150 oC for 8 h and then were calcined at 1000 oC for 5 h. The microstructure and phase analyses were investigated using SEM and XRD. The results showed that by using both silica and nano silica, with increasing pressure, the amount of wollastonite increased. At all pressures using silica, slurry with 50 wt% of solid content, SiO2/CaO molar ratio of 0.8 gave the optimum results while by using nano silica the optimum SiO2/CaO molar ratio was 1.

홍수와 산사태 취약성도 작성을 위한 전 세계 지공간데이터

이사로,Rezaie Fatemeh (사)지오에이아이데이터학회 2023 GEO DATA Vol.5 No.4

Susceptibility mapping is an important component of natural hazard risk assessment and management. Susceptibility maps for floods and landslides, which are particularly damaging to human life and property, can provide a comprehensive understanding of risk areas and factors related to flood and landslide susceptibility. To create a global flood and landslide susceptibility map, global geospatial data for 37,984 landslide and 6,682 flood locations, as well as 11 selected environmental factors were used to construct a geographic information system database. The 11 environmental factors found to influence flood and landslide occurrence were rainfall, slope, terrain position index, plane curvature, terrain wetness index, distance from rivers, land use, soil texture, soil moisture, geology, and temperature. These data were then used directly to create a global flood and landslide susceptibility map.