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RISS 인기검색어
- 검색키워드
- 저자 : Rethinam, Natarajan (검색결과 2 건)
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Ganesan Rethinam,Anand Duraiswamy,G. Dayanand Reddy,P. Elankani,Sampath Kundrapakkam Srinivasan 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.2
Acute kidney injury (AKI) is described as a disorder with a sudden loss of kidney function. AKI is also attributed to several aetiologies such as diabetes, cardiac problems, etc. Developing a therapy for AKI is challenging due to its complex pathophysiology. The present study investigated the effect of Sphaeranthus amaranthoides Burm f. aqueous extract, a Siddha Kalpha drug, against gentamicin-induced AKI. Animals were initially pre-administered with different concentrations of S. amaranthoides and later induced with gentamicin on the 8th day. Biochemical, anti-inflammatory and antioxidant markers were analysed. Further, HRLCMS analysis was carried out to identify the bioactive components. Components including myo-inositol, traumatic acid, rosmarinic acid, etc. were identified. In the animals induced with gentamicin, KIM1, LDH, GGT, creatinine, BUN and electrolytes were elevated in both serum and urine, while noted within normal range in S. amaranthoides pre-administered groups. Histopathology analysis revealed prevention of necrosis, tubular epithelial cell degeneration and glomerular congestion in S. amaranthoides administered animals. Lipid peroxidation, KIM1, Cystatin C, TNFα, IL6 and NFκB were within normal range in tissues. Thus, it is evident that S. amaranthoides is effective in protecting kidney damage and treating AKI. Further studies will be conducted to analyse the pathways resurrecting kidney damage.
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Subbiah, Karthick,Han-Seung, Lee,Yun Su, Lee,Jitendra Kumar, Singh,Seung-Jun, Kwon,Rethinam, Natarajan Elsevier Sequoia 2017 Sensors and actuators. B Chemical Vol.251 No.-
<P><B>Abstract</B></P> <P>In this study, we fabricated a solid-state reference electrode (SSRE) using cerium (Ce) doping in nickel ferrite (NiFe<SUB>2</SUB>O<SUB>4</SUB>) nanoparticles (NPs) to monitor the corrosion of steel rebar in concrete. The process for synthesis of NPs was sol-gel combustion. The NPs were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) probed with energy dispersive spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS). These techniques confirmed that the Ce doping was achieved successfully. The electrochemical stability of the fabricated SSRE was studied in buffer solution at different pH (7, 9, and 12) as well as in synthetic concrete pore solution (SCPS) and 3% NaCl-contaminated SCPS. Chloride ions do not affect the property of Ce<B>-</B>doped NiFe<SUB>2</SUB>O<SUB>4</SUB>. The stability of Ce-doped SSREs in different solutions as well as in concrete was constant throughout the exposure periods. The reversibility test results of Ce<B>-</B>doped NiFe<SUB>2</SUB>O<SUB>4</SUB> in SCPS solution for NiCe<SUB>0.1</SUB>Fe<SUB>1.9</SUB>O<SUB>4</SUB> (NFC1) and NiCe<SUB>0.5</SUB>Fe<SUB>1.5</SUB>O<SUB>4</SUB> (NFC5) showed 20 and 15mV, respective differences in potential between the forward and reverse scan. This result indicates that Ce<B>-</B>doped NiFe<SUB>2</SUB>O<SUB>4</SUB> SSREs have better reversibility behavior than NiFe<SUB>2</SUB>O<SUB>4</SUB> in SCPS. The reliability of NFC5 SSRE is excellent in SCPS and a concrete environment, and the maximum difference in both conditions was 5mV, which is within the range of acceptable values. This indicates that Ce<B>-</B>doped NiFe<SUB>2</SUB>O<SUB>4</SUB> SSRE can be used as a reliable embeddable sensor in concrete structures.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ce doped nickel ferrite was developed as a novel solid state reference electrode. </LI> <LI> Doping of Ce in nickel ferrite was successfully achieved. </LI> <LI> Stability of fabricated SSREs was studied in different pH solutions. </LI> <LI> Fabricated Ce doped SSREs attributed strong stability and high reversibility. </LI> </UL> </P>
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