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전희진,정미자,Kevin Dawson,Raymond L. Rodriguez,Soung-Jin Houng,Sung-Yun Cho,Jungae Jeun,Jin-Young Kim,Kyung Heon Kim,Kuen Woo Park,Cheong-Tae Kim,이성준 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.1
Hypolipidemic effects of Agastache rugosa essential oil (AREO) were investigated. Gas chromatographymass spectrometry (GC-MS) analysis showed that the major compound in AREO is limonene (47%, w/w). AREO (1 mg/mL) markedly reduced low density lipoprotein (LDL) oxidation (−93%). After 3-week feeding of AREO,plasma cholesterol (−28%) and triglyceride levels (−26%)were significantly decreased in C57BL/6J mice. Mouse hepatic transcriptome profiling with oligonucleotide microarray revealed that AREO altered the expression of 2,524 genes. Notably, significant reductions in sterol regulatory element binding factor (SREBF)-1 and SREBF-2 mRNA levels were detected. Protein expression of HMG-CoA reductase, a major target for SREBP-2, was reduced in HepG2 cells (−36%) and in mouse liver (−35%). AREO also significantly increased mRNA (+40%) and protein (+83%) expression of the LDL receptor in HepG2cells and mouse liver, respectively. Our findings suggest that AREO may prevent atherosclerosis via the inhibition of LDL oxidation, down-regulation of SREBF-2 and HMG-CoA reductase expression, and up-regulation of LDL receptor expression.
Effects of the isoflavone puerarin and its glycosides on melanogenesis in B16 melanocytes
Choi, Young-Mi,Jun, Hee-jin,Dawson, Kevin,Rodriguez, Raymond L.,Roh, Mi Ran,Jun, Jungae,Choi, Chung-Hyo,Shim, Jae-Hoon,Lee, ChoongHwan,Lee, Sang Jun,Park, Kwan-Hwa,Lee, Sung-Joon Springer-Verlag 2010 European food research and technology Vol.231 No.1
Effects of Acute Oral Administration of Vitamin C on the Mouse Liver Transcriptome
Hee-Jin Jun,김수경,Kevin Dawson,최달웅,김정상,Raymond L. Rodriguez,이성준 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.3
Vitamin C is a strong antioxidant that alters gene expression in cells, and its effects can be modified by cellular oxidative stress. We investigated the genome-wide effects of vitamin C on the in vivo transcriptome in the liver, which synthesizes various enzymes and proteins to defend against cellular oxidative stress. We fed mice vitamin C (0.056 mg/g of body weight) for 1 week and performed DNA microarray analysis with hepatic mRNA in fasting and refeeding states to mimic physiological conditions of oxidative stress. Significance analysis of microarray data identified approximately 6,000 genes differentially expressed in both fasting and refeeding states. In the fasting state, vitamin C induced overall energy metabolism as well as radical scavenging pathways. These were ameliorated in the refeeding state. These findings suggest that vitamin C has profound and immediate global effects on hepatic gene expression, which may help prevent oxidative stress, and that long-term treatment with vitamin C might reduce the risk of chronic disease.