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Realizing contact-less applications with Multi-Access Edge Computing
Pasika Ranaweera,Chamitha de Alwis,Anca D. Jurcut,Madhusanka Liyanage 한국통신학회 2022 ICT Express Vol.8 No.4
The entire world progression has ceased with the unexpected outbreak of the COVID-19 pandemic, and urges the requirement for contact-less and autonomous services and applications. Realizing these predominantly Internet of Things (IoT) based applications demands a holistic pervasive computing infrastructure. In this paper, we conduct a survey to determine the possible pervasive approaches for utilizing the Multi-Access Edge Computing (MEC) infrastructure in realizing the requirements of emerging IoT applications. We have formalized specific architectural layouts for the considered IoT applications, while specifying network-level requirements to realize such approaches; and conducted a simulation to test the feasibility of proposed MEC approaches.
Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice
Sachithra S. Ranaweera,Chanuri Y. Dissanayake,Premkumar Natraj,이영재,Chang-Hoon Han 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.6
Background: Sulforaphane (SFN) is an isothiocyanate compound present in cruciferous vegetables. Although the anti-inflammatory effects of SFN have been reported, the precise mechanism related to the inflammatory genes is poorly understood. Objectives: This study examined the relationship between the anti-inflammatory effects of SFN and the differential gene expression pattern in SFN treated ob/ob mice. Methods: Nitric oxide (NO) level was measured using a Griess assay. The inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression levels were analyzed by Western blot analysis. Pro-inflammatory cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, and IL-6) were measured by enzyme-linked immunosorbent assay (ELISA). RNA sequencing analysis was performed to evaluate the differential gene expression in the liver of ob/ob mice. Results: The SFN treatment significantly attenuated the iNOS and COX-2 expression levels and inhibited NO, TNF-α, IL-1β, and IL-6 production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. RNA sequencing analysis showed that the expression levels of 28 genes related to inflammation were up-regulated (> 2-fold), and six genes were down-regulated (< 0.6-fold) in the control ob/ob mice compared to normal mice. In contrast, the gene expression levels were restored to the normal level by SFN. The protein-protein interaction (PPI) network showed that chemokine ligand (Cxcl14, Ccl1, Ccl3, Ccl4, Ccl17) and chemokine receptor (Ccr3, Cxcr1, Ccr10) were located in close proximity and formed a “functional cluster” in the middle of the network. Conclusions: The overall results suggest that SFN has a potent anti-inflammatory effect by normalizing the expression levels of the genes related to inflammation that were perturbed in ob/ob mice.
Pham, Thanh Son,Ranaweera, Aruna Kumara,Ngo, Duc Viet,Lee, Jong-Wook Institute of Physics Publishing Ltd. 2017 Journal of Physics. D, Applied Physics Vol.50 No.30
<P>To meet both safety and efficiency demands of future wireless power transfer (WPT) systems, field leakage to the nearby environment should be controlled below a certain level. Therefore, field localization is one of the key issues in advanced WPT systems. Recently, metamaterials have shown great potential for enhanced control of electromagnetic propagation in various environments. In this work, we investigate a locally modified metamaterial to create a two-dimensional (2D) cavity for field localization at a sub-wavelength scale. We also show that the field localization in the cavity can be explained using Fano-type interference. We believe that this is one of the first works demonstrating that Fano-type interference can be applied for resonance-coupled mid-range WPT. Using the proposed approach, we achieve a localized WPT in a region that is eight times smaller than that of a transmit coil. At a distance of 0.6 meters, the measured efficiency is 56.5%, which represents a six-fold and two-fold enhancement compared to free space and uniform metamaterial slabs, respectively.</P>
Restoration of the adipogenic gene expression by naringenin and naringin in 3T3-L1 adipocytes
Lakshi A. Dayarathne,Sachithra S. Ranaweera,Premkumar Natraj,Priyanka Rajan,이영재,한창훈 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.4
Background: Naringenin and its glycoside naringin are well known citrus flavonoids with several therapeutic benefits. Although the anti-adipogenic effects of naringenin and naringin have been reported previously, the detailed mechanism underlying their anti-adipogenesis effects is poorly understood. Objectives: This study examined the anti-adipogenic effects of naringenin and naringin by determining differential gene expression patterns in these flavonoids-treated 3T3-L1 adipocytes. Methods: Lipid accumulation and triglyceride (TG) content were determined by Oil red O staining and TG assay. Glucose uptake was measured using a 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose fluorescent d-glucose analog. The phosphorylation levels of AMP-activated protein kinase (AMPK) and acetyl Co-A carboxylase (ACC) were observed via Western blot analysis. Differential gene expressions in 3T3-L1 adipocytes were evaluated via RNA sequencing analysis. Results: Naringenin and naringin inhibited both lipid accumulation and TG content, increased phosphorylation levels of both AMPK and ACC and decreased the expression level of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR) in 3T3-L1 adipocytes. RNA sequencing analysis revealed that 32 up-regulated (> 2-fold) and 17 down-regulated (< 0.6-fold) genes related to lipid metabolism, including Acaca, Fasn, Scd1, Mogat1, Dgat, Lipin1, Cpt1a, and Lepr, were normalized to the control level in naringenin-treated adipocytes. In addition, 25 up-regulated (> 2-fold) and 25 down-regulated (< 0.6-fold) genes related to lipid metabolism, including Acaca, Fasn, Fabp5, Scd1, Srebf1, Hmgcs1, Cpt1c, Lepr, and Lrp1, were normalized to the control level by naringin. Conclusions: The results indicate that naringenin and naringin have anti-adipogenic potentials that are achieved by normalizing the expression levels of lipid metabolism-related genes that were perturbed in differentiated 3T3-L1 cells.
기계적 생물학적 전처리 - 태국 PHITSANULOK 매립지에서의 사례연구
( Josef O. Tränkler ),( Renuka M. Ranaweera ),( Chettiyappan Visvanathan ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.2
본 연구에서는 1999년 초 이후 운영 중에 있는 한 매립지를 대상으로 하였다. 이 매립지에 관한 모든 이용가능한 정보는 세부조사의 입력자료로 사용된다. 또한 중간규모의 매립조와 lab-test에서 얻어진 결과는 예측치와 비교하는 데 이용되었다. 전처리 방법으로서 주어진 조건에서 windrow compost이 검토되었다. 9~12개월의 분해를 거친 물질은 매립지로 최종처분된다. 몬순기후의 영향을 받는 열대조건에서 퇴비화와 매립과정에서의 침출수 발생과 가스발생이 평가되었다. 그 결과로서 처리 및 미처리된 폐기물의 가스발생잠재력을 비교하기 위하여 측정되었다. 전처리, 즉, 기계적 생물학적 처리 또는 폐기물의 간단한 퇴비화(양질의 퇴비 생산을 위한 것이 아님)는 매립지 방출을 감소시킴으로써 열대지역, 즉, 태국에서 매립성능을 향상시키기 위한 한 가지 방법으로 제안된다. 비교결과와 20년간의 예측결과는 전처리를 통하여 합리적으로 방출량을 감소시킬 수 있음을 보여준다. 침출수로부터 축적되는 오염부하는 COD와 질소화합물의 경우 77~89% 감소가 가능하다. 총 가스 생산량은 35%이상 감소할 수 있으며 이는 70% 이상의 지구온난화잠재력의 저감을 가져올 수 있다. 퇴비화와 최종복토층에 간단한 메탄산화시스템을 둔 매립시스템을 조합함으로써 폐기물의 전처리로부터 얻을 수 있는 주요한 이득을 얻을 수 있다. 총폐기물량이 감소되어 매립공간을 줄이고 매립지의 수명을 연장할 수 있을 것 이다. 그러므로 사후 관리의 필요성은 현저하게 줄어들 것이다. A sanitary landfill under operation since the beginning of 1999 has been the objective of our analysis. All available information of this site served as input for a detailed analyzing. Further to that results derived from semi-scale lysimeters and lab-tests have been used to refine the comparison with respect to the forecast. As pre-treatment method windrow composting was discussed under given boundaries. After a period of 9-12 months degradation the material is supposed to be disposed of in that landfill. Leachate production and gaseous emission of both the composting and the landfill under tropical conditions influenced by monsoon have been assessed. Consequently gas production potential of both processed and untreated waste was determined for the comparison. Pre-treatment, i.e. mechanical biological processing or simple composting of MSW (not for the production of quality compost) is suggested as one option for improving the landfill performance in the tropical region viz. Thailand by reducing landfill emission. The outcome of the comparison and a prediction over a timeframe of 20 years proves the benefits of a reasonable emission reduction by a pre-treatment process. The cumulative pollution load from leachate can be diminished for COD and nitrogen compounds by 77 - 89%. The overall gas formation can be reduced by more than 35 % and the global warming potential will be abated by more than 70%. Main benefit of waste pre-treatment will be achieved in combination of composting and a landfilling with a simple methane oxidation system in the top layer. The total waste mass will be diminished saving landfill volume and achieving a lifetime extension of the landfill. Landfill after care will thus be reduced significantly.