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Jeon, Ah Ran,Lee, Jae Hoan,Mah, Jae-Hyung Elsevier 2018 LWT- Food science and technology Vol.92 No.-
<P>To evaluate the safety of Cheonggukjang, 60 different samples collected from 8 provinces all across the country were analyzed for biogenic amine contents by HPLC. The aromatic vasoactive amine (beta-phenylethylamine and tyramine) contents in some Cheonggukjang samples exceeded safe levels for consumption. Bacterial and enterococcal counts of Cheonggukjang samples were 9.70 +/- 0.43 and 6.00 +/- 1.52 Log CFU/g, respectively, and strains of Bacillus (n = 433) and Enterococcus (n = 55) isolated from Cheonggukjang samples were tested for biogenic amine production in assay media. Histamine and putrefactive amines (putrescine and cadaverine) were detected more abundantly in cultures of Bacillus strains, while tyramine was detected in larger quantities in cultures of Enterococcus strains. Subsequently, strains selected based on their specific abilities to produce the aforementioned respective biogenic amines were applied to soybeans to undergo fermentation, and biogenic amine contents in the soybeans were measured during the fermentation period. Unexpectedly, Bacillus strains produced slightly lower levels of histamine, but significantly higher levels of beta-phenylethylamine and tyramine than Enterococcus strains. Altogether, this study suggests that Bacillus species are as significant as Enterococcus species for biogenic amine production in Cheonggukjang, including tyramine, and should be controlled accordingly for the reduction of biogenic amine contents in the food.</P>
Jeon, A. Ran,Kim, Ji-Eun Frontiers Media S.A. 2018 Frontiers in cellular neuroscience Vol.12 No.-
<P>Redox modulation and <I>S</I>-nitrosylation of cysteine residues are the post-translational modifications of <I>N</I>-methyl-D-aspartate receptor (NMDAR) to regulate its functionality. Recently, we have reported that protein disulfide isomerase (PDI) reduces disulfide bond (S-S) to free thiol (-SH) on NMDAR. Since PDI is a modulator of <I>S</I>-nitrosylation on various proteins, it is noteworthy whether PDI affects <I>S</I>-nitrosylation of NMDAR in acute seizure and chronic epilepsy models. In the present study, we found that acute seizures in response to pilocarpine and spontaneous seizures in chronic epilepsy rats led to the reduction in <I>S</I>-nitrosylated thiol (SNO-thiol)-to-total thiol ratio on NMDAR, while they elevated nitric oxide (NO) level and <I>S</I>-nitrosylation on NMDAR. <I>N</I>-nitro-L-arginine methyl ester (L-NAME, a non-selective NOS inhibitor) did not affect seizure activities in both models, although it decreased SNO-thiol levels on NMDAR. However, PDI knockdown effectively inhibited pilocarpine-induced acute seizures and spontaneous seizures in chronic epilepsy rats, accompanied by increasing the SNO-thiol-to-total thiol ratio on NMDAR due to diminishing the amounts of total thiols on GluN1 and GluN2A. Therefore, these findings indicate that PDI may not be a NO donor or a denitrosylase for NMDAR, and that PDI knockdown may inhibit seizure activity by the <I>S</I>-nitrosylation-independent thiolation on NMDAR.</P>
Jeon, Hye-Ran,Pang, Eun-Kyoung,Pae, Ah-Ran,Kim, Myung-Rae,Kang, Na-Ra Korean Academy of Periodontology 2008 Journal of Periodontal & Implant Science Vol.38 No.2
Purpose: The aim of this study was to determine the survival rates of implants placed in grafted maxillary sinuses and compare the results obtained with graft materials, implant surfaces and timing of implant placement. Materials and Methods: Between January 1996 and December 2005, 391 implants were placed in 161 patients who underwent sinus grafting treatment simultaneously or separately at Ewha Womans University Hospital. According to inclusion criteria, 272 implants were placed in 102 patients with 112 sinus grafts (30 females, 72 males), aged 26 to 88 years (mean age $49.0{\pm}9.7$). The follow-up period ranged from 12 to 134 months (mean F/U $47{\pm}32$). Survival rates were evaluated according to graft material, implant surface and timing of implant placement. The Kaplan-Meier procedure and the log rank (Mantel-Cox) test were used to estimate survival rates and test for equality of survival rates between different groups of patients. Results: Ten-year cumulative survival rate for implants placed in the grafted sinuses was 90.1%. The survival rates for autogenous bone, combination and bone substitutes were 94.6%, 85.9% and 100%, respectively (p > 0.05). According to implant surface, survival rates were 84.8% in machined group and 97.5% in rough group (p < 0.05). The survival rates were 92.9% in delayed group and 86.0% in simultaneous group (p > 0.05). Conclusion: Ten-year cumulative survival rate for implants placed in the grafted sinuses was 90.1%. Rough-surfaced implants have a higher survival rate than machined-surfaced implants when placed in grafted sinuses (p < 0.05).