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BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma
Rajabpour, Fatemeh Vand,Raoofian, Reza,Youssefian, Leila,Vahidnezhad, Hassan,Shahshahani, Mostafa Mirshams,Fathi, Hamidreza,Noormohammadpour, Pedram,Hesari, Kambiz Kamyab,Hashemzadeh-Chaleshtori, Mort Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Background: BMI1, TWIST1 and SNAI2/SLUG have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma and BMI1 expression could identify subtypes of Merkel cell carcinoma (MCC). However, BMI1, TWIST1 and SNAI2 expression levels in basal cell carcinomas (BCCs) have not been elucidated. We hypothesized BCC could be a good model system to decipher mechanisms which inhibit processes that drive tumor metastasis. The aim of this study was to examine the mRNA expression level of BMI1, TWIST1, and SNAI2 in BCCs. Materials and Methods: Thirty-five fresh non-metastatic BCC tissue samples and seven fresh normal skin tissue samples were evaluated by real-time RT-PCR. Results: BMI1 and TWIST1 demonstrated marked down-regulation (p<0.00l, p=0.00l respectively), but SNAI2 showed no significant change (p=0.12). Conclusions: Previous literature has clearly demonstrated a positive association between BMI1 and TWIST1 expression and metastatic BCC, aggressive SCC and melanoma. Here, we demonstrated a negative association between BMI1 and TWIST1 mRNA expression level and BCC.
Ali Rajabpour,Ali Reza Abdali Mashahdi,Mohammad Reza Ghorbani 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.1
Botanical insecticides have long been considered as alternatives to synthetic chemical insecticides in IPM programs. Effects of aqueous and ethanolic extracts obtained from buttonwood, Conocarpus erectus L. (Combretaceae), leaves on a major kind of stored product pests, Tribolium castaneum Herbst (Coleoptera: Tenebrionidae), were evaluated under laboratory conditions. For this purpose, LC 50 , repellency, antifeedant properties, and some biological effects (including body weight, immature developmental time and survival) of the insect were determined. The aqueous and ethanolic extracts were highly toxic to the larvae and adults. Calculated LC 50 values ranged between 2.6 and 193.4 (g/kg). Both extracts had repellent and antifeedant properties against the adults. The extracts adversely affected the larval and pupal weights, developmental time, and survival. Aqueous extracts were more effective only for the LC 50 values and only in females. All other measured parameters do not differ between the two extracts. The bioactive properties might be related to high amounts of alkaloid, phenol and tannin. Aqueous extract of the plant leaves may be a useful alternative for chemical insecticides.
Temperature profile for nanoscale Poiseuille flow: a multiscale study
Fahim Faraji,Ali Rajabpour,Farshad Kowsary 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.2
In this study, we calculated the temperature profile for a nanoscopic Poiseuille flow system via two methods. The first method involved employing the tools of Molecular dynamics (MD) simulation, and the second method involved solving Navier’s equation analytically while the rates of fluid dynamic viscosity and thermal conductivity were calculated through MD. We used a temperature jump model as the boundary condition required for the latter method, which was also calculated through MD. We repeated the calculations for various amounts of wall temperature and fluid-wall interaction strength, and we observed a satisfactory agreement between the results of the two methods.
Fluid heating in a nano-scale Poiseuille flow: A non-equilibrium molecular dynamics study
Fahim Faraji,Ali Rajabpour 한국물리학회 2017 Current Applied Physics Vol.17 No.12
In this paper we develop a non-equilibrium molecular dynamics computer simulation to study the fluid heating in a nano scale Poiseuille flow system and discuss the effects of the fluid-wall interaction strength and wall temperature on the fluid heating. We calculate the fluid temperature distribution, as well as the heat flux from the fluid towards the walls and the interfacial thermal resistance and discuss the variations of the fluid heating caused by the viscous and surface frictions as the fluid-wall interaction strength and wall temperature vary. It is found that as the fluid-wall interactions strengthen, the fluid heating diminishes. In weak interactions, the heat flux from the fluid to the wall is almost independent of the wall temperature while the interfacial thermal resistance decreases with increased wall temperature and the surface friction is the major contribution to the fluid heating; in contrast, in large interactions, both the heat flux and thermal resistance increase with increased wall temperature and the viscous friction is the major contribution to the fluid heating.
Ahmad Rashedi,Ali Rajabpour,Arash Rasekh,Nooshin Zandi-Sohani 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.3
The interactions between two natural enemies (NEs) were studied in a tritrophic system to evaluate the efficacy of simultaneous releases of a parasitoid, Lysiphlebus fabarum Marshal (Hymenoptera: Braconidae) and a predator, Orius albidipennis Reuter (Heteroptera: Anthocoridae) against Aphis fabae Scopoli (Homoptera: Aphididae). Three experiments were performed to evaluate the prey preference of a predator to parasitized versus unparasitized aphid hosts; to investigate the emission of volatile synomones by the host plant, Vicia fabae, and to determine its behavioral effect on the NEs; and to determine behavioral effect of volatile infochemicals between NEs. Results showed that the female predatory bug did not show significant preference between parasitized and unparasitized aphids, but the male bug had significant preference for parasitized mummies. Olfactometry trials documented that both NEs were significantly attracted to volatile cues released by the host plant infested with the aphid. Each of the NEs avoided odors which indicated the presence of another intraguild competitor. Therefore, simultaneously releases of the NEs are not recommended.
Molecular Dynamics Modeling of Buckling Behavior of Hydrogenated Graphyne
A. Montazeri,S. Ebrahimi,A. Rajabpour,H. Rafii-Tabar 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.7
Molecular dynamics simulation is employed to explore the influence of hydrogen adsorption on the stability behavior of graphyne (GY) as a new allotrope of carbon. The strain for the onset of buckling is determined for pristine GY and the results are compared with those for perfect graphene nanoribbons under identical conditions. The results reveal that due to the presence of triple C–C bonds in the GY structure, which are harder to rotate and bend in compression compared to single bonds, the new allotrope is stiffer than graphene during buckling phenomenon. In addition, the effect of hydrogen adsorption on the stability behavior of GY is examined with different H coverage in the range 0–50%. It is concluded that this adsorption promotes a rapid buckling which is attributed to the conversion of the stiff in-plane carbon bonding in the GY structure to the out-of-plane bonding which is weaker and easier to bend in compression. Finally, a critical value of adsorption is found above in which such a trend is not observed.