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RISS 인기검색어
- 검색키워드
- 저자 : Rahul Deshmukh (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Normal Values of High-resolution Anorectal Manometry of Healthy Indians
Rahul Deshmukh,Akash Shukla,Sanjay Chandnani,Pravin M Rathi,Pratik Tibdewal,Shubham Jain,Nitin Ramani,Parmeshwar Junare,Partha Debnath,Leela Shinde,Asif Bagwan,Megha Meshram 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3
Background/AimsHigh-resolution anorectal manometry (HRAM) measures anal sphincter function and anorectal co-ordination. This study aims to provide normal data for HRAM and evaluate the effect of gender, age, and body mass index (BMI) on anorectal functions in healthy Indian subjects. MethodsHRAM was performed on 93 healthy volunteers using a 20-channel, water-perfused catheter. We evaluated anorectal pressures, rectal sensation, and balloon expulsion time. Measurements were recorded during rest, squeeze, and simulated defecation (push). ResultsMedian anal resting pressure (88 mmHg vs 94 mmHg, P = NS), anal squeeze pressure (165 mmHg vs 147 mmHg, P = NS) were not significantly different between males and females. Rectal pressure (70 mmHg vs 54 mmHg, P = 0.024) and anal pressure (82 mmHg vs 63 mmHg, P = 0.008) during simulated evacuation without rectal distention, were higher in males. The threshold for the first sensation was lower in females (40 mL vs 30 mL, P = 0.021) but desire to defecate (105 mL vs 90 mL, P = NS) and maximum tolerable volume (160 mL vs 140 mL, P = NS) were not significantly different in males and females. Anal residual pressure (median mmHg 83 vs 71 mmHg, P = 0.025) was higher in subjects < 40 years of age. Maximum anal squeeze pressure (185 mmHg vs 165 mmHg, P = 0.024) and maximum rectal pressure (75 mmHg vs 62 mmHg, P = 0.032) during push higher in BMI < 23 kg/m2. ConclusionsThe present study provides normal data for the Indian population that can be used for comparison and further work. Age, gender, and BMI affect anorectal parameters in HRAM and should be considered while reporting.
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Rahul Gaybarao Naik,Arun Suresh Dodamani,Mahesh Ravindra Khairnar,Harish Chaitram Jadhav,Manjiri Abhay Deshmukh 대한치과보존학회 2016 Restorative Dentistry & Endodontics Vol.41 No.4
Objectives: Glass ionomer cements (GICs), which are biocompatible and adhesive to the tooth surface, are widely used nowadays for tooth restoration. They inhibit the demineralization and promote the remineralization of the tooth structure adjacent to the restoration, as well as interfere with bacterial growth. Hence, the present study was conducted to assess and compare the antimicrobial activity of three commercially available GICs against two cariogenic bacteria. Materials and Methods: An agar plate diffusion test was used for evaluating the antimicrobial effect of three different GICs (Fuji IX, Ketac Molar, and d-tech) on Streptococcus mutans (S. mutans) and Lactobacillus acidophilus (L. acidophilus). Thirty plates were prepared and divided into two groups. The first group was inoculated with S. mutans, and the second group was inoculated with L. acidophilus. These plates were then incubated at 37℃ for 24 hours. Zones of bacterial growth inhibition that formed around each well were recorded in millimeters (mm). Results: The zones of inhibition for Fuji IX, Ketac Molar, and d-tech on S. mutans were found to be 10.84 ± 0.22 mm, 10.23 ± 0.15 mm, and 15.65 ± 0.31 mm, respectively, whereas those for L. acidophilus were found to be 10.43 ± 0.12 mm, 10.16 ± 0.11 mm, and 15.57 ± 0.13 mm, respectively. Conclusions: D-tech cement performed better in terms of the zone of bacterial inhibition against the two test bacteria, than the other two tested glass ionomers.
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Naik, Rahul Gaybarao,Dodamani, Arun Suresh,Khairnar, Mahesh Ravindra,Jadhav, Harish Chaitram,Deshmukh, Manjiri Abhay The Korean Academy of Conservative Dentistry 2016 Restorative Dentistry & Endodontics Vol.41 No.4
Objectives: Glass ionomer cements (GICs), which are biocompatible and adhesive to the tooth surface, are widely used nowadays for tooth restoration. They inhibit the demineralization and promote the remineralization of the tooth structure adjacent to the restoration, as well as interfere with bacterial growth. Hence, the present study was conducted to assess and compare the antimicrobial activity of three commercially available GICs against two cariogenic bacteria. Materials and Methods: An agar plate diffusion test was used for evaluating the antimicrobial effect of three different GICs (Fuji IX, Ketac Molar, and d-tech) on Streptococcus mutans (S. mutans) and Lactobacillus acidophilus (L. acidophilus). Thirty plates were prepared and divided into two groups. The first group was inoculated with S. mutans, and the second group was inoculated with L. acidophilus. These plates were then incubated at $37^{\circ}C$ for 24 hours. Zones of bacterial growth inhibition that formed around each well were recorded in millimeters (mm). Results: The zones of inhibition for Fuji IX, Ketac Molar, and d-tech on S. mutans were found to be $10.84{\pm}0.22mm$, $10.23{\pm}0.15mm$, and $15.65{\pm}0.31mm$, respectively, whereas those for L. acidophilus were found to be $10.43{\pm}0.12mm$, $10.16{\pm}0.11mm$, and $15.57{\pm}0.13mm$, respectively. Conclusions: D-tech cement performed better in terms of the zone of bacterial inhibition against the two test bacteria, than the other two tested glass ionomers.
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Evaluating the effect of cationic peptide K16ApoE against Staphylococcus epidermidis biofilms
Ahlschwede Kristen M.,Amissah Felix,Deshmukh Rahul 한국약제학회 2022 Journal of Pharmaceutical Investigation Vol.52 No.1
Purpose Staphylococcus epidermidis is one of the most common causative pathogens of nosocomial-related infections. It is known to form biofilms on indwelling medical devices. The negatively charged extracellular matrix of the biofilm can entrap bacteria, thus limiting the diffusion of therapeutic agents and contributing to the ineffectiveness of therapeutic agents against the bacteria. To combat this, we investigated the effectiveness of a cationic peptide, K16ApoE, with bioadhesive properties to serve as an anti-adhesion agent. Methods The ability of K16ApoE to serve as an anti-adhesive agent was evaluated using crystal violet staining to quantify the degree of inhibition of biofilm formation. The minimum inhibitory concentration was determined by concurrently incubating the S. epidermidis inoculum with K16ApoE (0–250 μg/mL) for 24 h, after which a relative biofilm density assay was performed. Inhibition of the surface adhesion of biofilms to various matrices was also evaluated by coating K16ApoE on ceramic discs as well as polyvinyl chloride (PVC) or silicone catheter extension tubing. Bovine serum albumin (BSA), pure unconjugated ApoE or K16 peptide were used as controls. Results K16ApoE (250 μg/mL) was very effective at reducing biofilm integrity by 99.92%. ApoE or K16 alone was largely ineffective compared to K16ApoE. In addition, catheter tubing pretreated with K16ApoE showed a significant (83 ± 12.7%) reduction in the formation of adherent biofilms. Conclusion These results demonstrate that K16ApoE can serve as an effective anti-adhesive agent to prevent the formation of an adherent bacterial biofilm on matrices with different surface properties.
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