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Clinical Characteristics of Korean Severe Asthma Patients
( Joon Young Choi ),( Kwang Ha Yoo ),( Hyoung Kyu Yoon ),( Seung Won Ra ),( Jae Ha Lee ),( Youlim Kim ),( Sang Heon Kim ),( Yong Bum Park ),( Chin Kook Rhee ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Purpose Severe asthma account for approximately 5-15% of all asthma patients, and is associated with poor health outcomes and high socioeconomic burden. In this study, we aimed to present clinical characteristics of Korean severe asthma patients in analysis of Korean patients enrolled in the International Severe Asthma Registry (ISAR). Methods ISAR is a multi-national and observational severe asthma registry, which collect data by both retrospective and prospective measures. This study extracted data of Korean patients, and analyzed clinical characteristics including demographics, smoking histories, comorbidities, FeNO, IgE, pulmonary function test Results and history of exacerbation. Also, we measured asthma control status and drug adherences. Results Total of 160 severe asthma patients were included in this study. Mean age was 57.1± 13.9 and 37.5% of patients were male (Table 1). 69% of patients were never smokers and mean pack-year was 16.9±13.5 in ever smokers. 63.5% patients suffer allergic rhinitis and 10.9% had nasal polyp. Mean value of FeNO was 43.5±35.4, and IgE was 431.2 ± 691.9. Mean FEV1 was 1.9 ± 0.7 L, and number of exacerbations were 0.5± 1.1 in 1 year. Only 9.8% of patients were at well-controlled state, and 45.5% were uncontrolled (fig 1A). 57% patients were presumed to have poor drug adherences (fig 1B). 66% of patients used triple therapy (fig 2A) and 66% used leukotriene receptor antagonists (fig 2B). Oral corticosteroid use were found in 24% of patients. Conclusions We presented clinical characteristics of Korean severe asthma patients, enrolled in ISAR.
Sung, Nayoung,Han, Ae Ra,Park, Chan Woo,Park, Dong Wook,Park, Joon Cheol,Kim, Na Young,Lim, Kyung Sil,Shin, Ji Eun,Joo, Chang Woo,Lee, Seung Eun,Kim, Jae Won,Lee, Sung Ki,IVIG Task Force Korean Societ The Korean Society for Reproductive Medicine 2017 Clinical and Experimental Reproductive Medicine Vol.44 No.1
The task force of the Korean Society for Reproductive Immunology recommends intravenous immunoglobulin G treatment in women with reproductive failure, including recurrent pregnancy loss and/or repeated implantation failure, who show cellular immune factors such as abnormal natural killer cell levels, natural killer cell cytotoxicity, and/or type 1 T helper immunity.
Inactivation of <i>Vibrio vulnificus</i> Hemolysin by Oligomerization but Not Proteolysis
Shin, Sung-Heui,Sun, Hui-Yu,Choi, Mi-Hwa,Park, Ra-Young,Bai, Young-Hoon,Kim, Choon-Mee,Kim, Soo-Young,Kim, Young-Ran,Lee, Shee-Eun,Rhee, Joon-Haeng Pharmaceutical Society of Japan 2005 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.28 No.7
<P><I>Vibrio vulnificus</I> extracellular protease (VvpE) is believed to destroy its hemolysin (VvhA) in the late growth phase, without obvious experimental evidence. So, we attempted to elucidate the mechanism. The hemolytic activity steeply increased with the expression of the VvhA in the early growth phase, and then abruptly declined with the expression of VvpE in the late growth phase. However, the VvhA activity also abruptly declined in a VvpE-deficient mutant. In Western blot, the degradation of VvhA was not observed; instead, the oligomerization of VvhA increased with the concomitant loss of hemolytic activity. These results evidently indicate that the inactivation of VvhA is due to the novel oligomerization of VvhA by unknown mechanism, but not to the destruction of VvhA by VvpE, so that the routine functional assay measuring hemolytic activity cannot reflect the actual production of VvhA.</P>
The Prevalence and Characteristics of Brown Adipose Tissue in an $^{18}F$-FDG PET Study of Koreans
Park, Joon-Yeun,Lim, Jung-Sub,Park, Eun-Young,Cho, A-Ra,Kim, Byeong-Il,Cheon, Gi-Jeong,Choi, Chang-Woon,Lim, Sang-Moo The Korea Society of Nuclear Medicine 2010 핵의학 분자영상 Vol.44 No.3
Purpose The object of this study was to evaluate the prevalence and characteristics of brown adipose tissue (BAT) in Korean subjects using $^{18}F$-fluorodeoxyglucose positron emission tomography ($^{18}F$-FDG PET). Methods Six thousand and five consecutive $^{18}F$-FDG PET/CT scans of 5,115 patients (3,007 females and 2,108 males, mean age 53.5 years) were retrospectively reviewed. We characterized the nature of BAT, such as its location, and we assessed the influence of sex, age, body mass index (BMI), and temperature on BAT. Results The prevalence of BAT in Koreans in a single $^{18}F$-FDG PET/CT scan in average conditions was 1.07%. The BAT detection rate was higher in females than males (1.32% vs 0.73%), and also with younger age (7.94% vs 0.73%), lower BMI (BMI with BAT, 21.1 vs BMI without BAT, 23.15) and cold outdoor temperature (1.65% vs 0.49%). The most frequent location of BAT was the supraclavicular area (left, 0.91%; right, 0.88%) and ventral neck area (left, 0.62%; right, 0.63%). Conclusions The characteristics of BAT in Koreans are not different from those described for Caucasians. However, the low prevalence of BAT in our study might be related to some scan condition like ambient temperature, but further study is needed.
( Young Joon Choi ),( Hyun Il Lee ),( Ho Jong Ra ),( Do Yon Hwang ),( Tae Kyung Kim ),( Sang Jun Shim ) 대한슬관절학회 2014 대한슬관절학회지 Vol.26 No.4
purpose: The purpose of this study is to evaluate the risk of sequential bilateral total knee arthroplasty (TKA) under 1 anesthesia in patients 75 years or older. materials and methods: Patients aged 75 years or older who underwent sequential bilateral TKA (bilateral group, n=159) and unilateral TKA (unilateral group, n=159) between 2002 and 2012 were selected. All patients were evaluated for underlying medical diseases, such as cardiac, pulmonary, and renal problems, and high-risk patients were recommended to postpone the surgery. We compared the underlying diseases, major postoperative complications, and the length of hospital stay between bilateral and unilateral groups. results: The prevalence of underlying diseases of the bilateral group was 74.8% and major complications occurred in 6 patients (3.8%). The prevalence of underlying diseases of the unilateral group was 52.4% and complications were observed in 4 patients (2.4%). Although the complication rate of the bilateral group was slightly higher than that of the unilateral group, the difference was not statistically meaningful (p=0.204). The length of hospital stay was 21.9 days for the bilateral group and 24.9 days for the unilateral group. conclusions: There was no significant difference in postoperative complications between groups. The result shows that bilateral TKA can be relatively safe compared with unilateral TKA in patients 75 years or older. However, careful selection of low-risk patients is advised.
Shin, Sung-Heui,Sun, Hui-Yu,Park, Ra-Young,Kim, Choon-Mee,Kim, Soo-Young,Rhee, Joon-Haeng Elsevier 2005 FEMS microbiology letters Vol.247 No.2
<P><B>Abstract</B></P><P>In order to elucidate the role of <I>Vibrio vulnificus</I> metalloprotease VvpE in the uptake of iron from human transferrin, we constructed a VvpE-deficient mutant and a merozygotic <I>vvpE</I>-transcriptional reporter from the wild type strain MO6-24/O. All three strains were able to grow only in deferrated Heart Infusion broth (DF-HI) with human holotransferrin (HT), but not in DF-HI containing partially iron-saturated transferrin or apotransferrin, without noticeable differences among the strains. All strains consumed most iron in the early growth phase. Both the transcription and extracellular production of VvpE proceeded at undetectable levels when bacterial growth was severely retarded in the DF-HI. When HT or FeCl<SUB>3</SUB> was added to the DF-HI, the retarded bacterial growth was restored and <I>vvpE</I> transcription dramatically increased in the late growth phase, but the extracellular VvpE production was negligible as compared to its transcription. All strains were unable to degrade HT even in normal HI broth containing HT, in which extracellular VvpE activity was remarkably high. The uptake of iron from HT in all strains was consistent with the production of catechol-siderophore rather than hydroxamate-siderophore. Similar results were also observed when clinical isolates from septicemic patients were used. In conclusion, we determined that VvpE was not directly involved in the siderophore-mediated iron-uptake from human transferrin. In addition, the discrepancy between the transcription and extracellular production of VvpE suggests that additional posttranscriptional events are involved in the extracellular production of VvpE.</P>
김상호 ( Sang-ho Kim ),안소라 ( So-ra Ahn ),김성준 ( Seong-joon Kim ) 한국농공학회 2013 한국농공학회 학술대회초록집 Vol.2013 No.-
하천의 유량 측정은 대부분 홍수 예보지역, 댐 상류지역, 대하천 및 유역내 주요 지점을 위주로 수행되고 있으며 이에 따라서 중소하천과 소유역에 대한 유량 산정에 어려움이 있다. 유역 유출모형에서는 유역의 지형학적 매개변수를 기반으로 강우-유출 현상을 해석하고 있으며, 특정 지점에 대해서 계측된 수문자료로 보정 및 최적화된 매개변수를 이용하여 유역 내 홍수량을 모의할 수 있다. 하지만 미계측 유역의 홍수량 산정은 통상 인근관측소 자료를 면적비로 전이시켜 사용하거나 인근 계측유역에서 유출모형의 매개변수를 추정하여 매개변수를 전이시켜 사용하고 있다. 본 연구에서는 남한전체를 대상으로 GIS기법에 의해 1 : 5,000 NGIS자료로부터 DEM과 하천망을 생성하였고, 이를 이용하여 수자원단위지도 기반의 850개 단위유역에 대해 23개의 유역 및 하천특성인자들을 (유역면적 및 둘레, 유역평균폭, 형상인자, 형상계수, 단일형상계수, 원형비, 세장률, 하천총수, 최원유로연장, 총하천연장 및 주하천연장, 수계밀도, 수계빈도, 수계유지상수, 섬세비, 기복비, 상대기복, 기복수, 평균표고, 평균경사 및 향, 하상경사) 추출함으로써 유역의 지형학적 특성을 파악하였다. 계측유역에서 추정한 유출모형의 매개변수를 미계측 유역으로 전이시키기 위해 두 개의 다변량 통계기법인 주성분분석과 계층적 군집분석을 연계한 매개변수 지역화 기법을 이용하여 인자들 간의 상관관계를 분석함으로써 각 유역을 특징짓는 주요인자들을 추출하였다. 유출모형은 개념적 집중형 모형인 ReFH 모형을 선정하였으며 계측유역의 유출구 지점에 대해서 모형을 보정하고 매개변수를 추정하였다. 계측 및 미계측 유역의 구분은 유역 출구점에 대한 관측소 유무 및 자료보유 정도를 분석하여 구분하였으며, 계측유역은 기상청, 국가 수자원관리 종합정보시스템(WAMIS), 4대강 (한강, 금강, 낙동강, 영산강) 홍수통제소의 기상 및 수문자료를 이용하여 구축하였다. 매개변수 지역화 결과는 계측유역의 일부를 미계측 유역으로 가정하여 적용하였고 유출해석을 수행한 결과 미계측유역의 모의결과는 첨두유량 및 첨두시간에 대해서 관측 수문곡선을 잘 재현하였으며, 총유출량과 첨두유량 및 첨두시간에 대해서 관측값과 선형의 높은 상관성을 일관되게 보이고 있다. 따라서 본 연구에서는 지역화된 매개변수를 통한 미계측 유역의 강우-유출을 평가함으로써 미계측 유역 홍수량 산정 방안으로 활용될 수 있음을 검증하였다.