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Xiaoyun Chai,Qingyan Sun,Shichong Yu,Yongwei Jiang,Yan Zou,Qiuye Wu,Dazhi Zhang,Yuan-Ying Jiang,Yongbing Cao 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.11
A series of novel 1, 2, 4-triazole derivatives (9a-p) have been designed and synthesized as the potential antifungal agents. All compounds were characterized by 1H-NMR, 13C-NMR, and LCMS. Their antifungal activities against seven human pathogenic fungi were evaluated in vitro by measuring the minimal inhibitory concentrations. Most of the tested compounds were found to be more potent against Candida albicans than the control drug fluconazole.
Marein Prevented LPS-Induced Osteoclastogenesis by Regulating the NF-κB Pathway In Vitro
( Yuling Li ),( Jing Zhang ),( Caiping Yan ),( Qian Chen ),( Chao Xiang ),( Qingyan Zhang ),( Xingkuan Wang ),( Ke Jiang ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.2
Many bone diseases such as osteolysis, osteomyelitis, and septic arthritis are caused by gramnegative bacterial infection, and lipopolysaccharide (LPS), a bacterial product, plays an essential role in this process. Drugs that inhibit LPS-induced osteoclastogenesis are urgently needed to prevent bone destruction in infective bone diseases. Marein, a major bioactive compound of Coreopsis tinctoria, possesses anti-oxidative, anti-inflammatory, anti-hypertensive, antihyperlipidemic, and anti-diabetic effects. In this study, we measured the effect of marein on RAW264.7 cells by CCK-8 assay and used TRAP staining to determine osteoclastogenesis. The levels of osteoclast-related genes and NF-κB-related proteins were then analyzed by western blot, and the levels of pro-inflammatory cytokines were quantified by ELISA. Our results showed that marein inhibited LPS-induced osteoclast formation by osteoclast precursor RAW264.7 cells. The effect of marein was related to its inhibitory function on expressions of pro-inflammatory cytokines and osteoclast-related genes containing RANK, TRAF6, MMP-9, CK, and CAII. Additionally, marein leads to markedly inhibited NF-κB signaling pathway activation in LPS-induced RAW264.7 cells. Concurrently, when the NF-κB signaling pathway was inhibited, osteoclast formation and proinflammatory cytokine expression were decreased. Collectively, marein could inhibit LPS-induced osteoclast formation in RAW264.7 cells via regulating the NF-κB signaling pathway. Our data demonstrate that marein might be a potential drug for bacteria-induced bone destruction disease. Our findings provide new insights into LPS-induced bone disease.
Yongwei Yu,Qing Yang,Jiangquan Ma,Wenliang Sun,Chong Yin,Xiazhang Li,Jun Guo,Qingyan Jiang,Zhiyuan Lu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.11
A novel strontium titanate/binary metal sulfide (SrTiO3/SnCoS4) heterostructure was synthesized by a simple two-step hydrothermal method. The visible-light-driven photocatalytic performance of SrTiO3/SnCoS4 composites was evaluated in the degradation of methyl orange (MO) under visible light irradiation. The photocatalytic performance of SrTiO3/SnCoS4-5% is much higher than that of pure SrTiO3, SnCoS4, SrTiO3/SnS2 and SrTiO3/CoS2. The SrTiO3/SnCoS4 composite material with 5 wt.% of SnCoS4 showed the highest photocatalytic efficiency for MO degradation, and the degradation rate could reach 95% after 140 min irradiation time. The enhanced photocatalytic activity was ascribed to not only the improvement of visible light absorption efficiency, but also the construction of a heterostructure which make it possible to effectively separate photoexcited electrons and holes in the two-phase interface.