A nonNMDA antagonist, GYKI 52466 improves microscopic O₂balance in the cortex during focal cerebral ischemia

Chi, Oak Z.,Chang, Qiang,Wang, Guolin,Liu, Xia,Harvey R. Weiss 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Oak Z.Chi,Qiang Chang, Guolin Wang*, Xia Liu, Harvey R. Weiss□.Deprtments of Anesthesai, Departments of Physiology and Biophysics, University of Medicne and Dentisrty of New Jersey,Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA and*Department of Anesthesia, Medical University, Tianjing, People's Republic of China. A non-NMDA antagonist, GYKI 52466 improves microscopic O² balance in the cortex during focal cerebral ischemia. Proceedings of International Symposium on East-West Medicine, Seoul. 172-182, 1999.-This study was performed to test whether GYKI 52466, a non-NMDA receptor antagonist, would improve microregional oxygen supply and consumption balance in the focal cerebral ischemic area. Rats were anesthetized with 1.4% isoflurance. For the GYKI Group (n=8), 19 min before middle cerebral artery (MCA) occlusion, a bolus of 5mg/kg of GYKI 52466 iv was administered and was followed by an infusion of 5mg/kg/hr. For the control Group(n=8), the same volume of the vehicle was administered. One hour after MCA occlusion, regional cerebral blood flow (rCBF) was measured using the 14C-iodoantipyrine autoradiographic technique. Microscopic arterial and venous oxygen saturations were determined using microspectrophotometry. In the cortex contralateral to MCA occlusion, the average rCBF and the average O² consumption were lower in the GYKI Group than in the Control Group (rCBF:GYKI 65.5±24.1, Control 97.7 33.4ml/100g/min;O² consumption: GYKI3.9±1.2, Control 6.2±2.5ml O²/100g/min) without a significant difference in the number of veins with SvO²<50%. In the ischemic cortex, the number of veins with SvO²<50% was significantly smaller in the GYKI Group (21 veins out of 63)than in the Control Group(45 out of 59)without a significant difference in the average rCBF(GYKI44.9±17.7, Control 29.7±10.4) or regional O² consumption between these two groups (GYKI 3.3±1.4,Control 27.7±1.2). Our data demonstrated that GYKI 52466 was effective in improving microscopic O² balance in the focal ischemic cortical area of the brain and it decreased O² consumption in the non-ischemic cortex. [Neurological Research 1999;21:299-304]

Enhancement of Cellulase Efficiency on Hardwood Dissolving Pulp by Cationic Polyacrylamide Treatment

Qiang Wang,Tianzhong Yuan,Guihua Yang,Xingxiang Ji,Gaojin Lyu,Jiachuan Chen 한국펄프·종이공학회 2016 한국펄프·종이공학회 학술발표논문집 Vol.2016 No.10

Efficient single-phase full-bridge soft-switching inverter

Wang, Qiang,Wang, Youzheng The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.4

A MOSFET is often applied as the switch in medium and small power single-phase full-bridge inverters. In order to achieve efficient operation at a high switching frequency, a new efficient inverter is presented in this paper. In addition, two sets of identical auxiliary units are arranged on the two bridge arms. When the main switches need to be turned on in each switching period, the voltage across the resonant capacitor can become zero. Thus, the main switching device can achieve zero-voltage turn-on, which can eliminate the capacitive turn-on loss existing in the MOSFET and help with the efficient operation of the inverter. The working process of the auxiliary unit and the design rules of the parameters are analyzed. Experimental results indicate that the main switching device can work in the state of zero-voltage soft-switching, and that the rated efficiency in the inverter is equal to 98.9%. This is more than that of similar inverters. This topology is significant for studies on efficient single-phase full-bridge inverters with medium and small power.

Theoretical Support and Research Trend of Senior Tourism Research

Qiang Wang 융합관광콘텐츠학회 2023 융합관광콘텐츠학회 학술대회 발표집 Vol.2023 No.7

Analysis of Corrosion-induced Expansive Stress and Internal Cracking of Concrete under Considering Cover Thickness

Wang Ben,Wang Hong,Zhang Zhi-qiang 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.10

After considering the actual dimension of reinforced concrete structure, the thickness and geometrical boundary condition of concrete cover, the model of corrosion-induced expansion can be simplified as a plane model of semi-infinite body. Through theoretical analysis, formulas are got to calculate corrosion-induced expansive stress of concrete cover. The results shows that: the corrosion-induced crack originated on the interface between concrete and the corrosion layer, if initial cracking is not in vertical direction to the surface of concrete cover, cracks along the rebar induced by the uplift and horizontal tension stress on the surface of the concrete cover may occur from its outer to inner, it also presents that the anti-rust ability of reinforced concrete structures could be improved by increasing the thickness of concrete cover, raising the grade of concrete, and increasing the diameter of rebar. Compared with the existing literatures, the precision of the theoretical solutions is verified.

Efficacy and Safety of a Steroid-Free Immunosuppressive Regimen after Liver Transplantation for Hepatocellular Carcinoma

Qiang Wei,Xiao Xu,Chao Wang,Runzhou Zhuang,Li Zhuang,Lin Zhou,Haiyang Xie,Jian Wu,Min Zhang,Yan Shen,Weilin Wang,Shusen Zheng 거트앤리버 소화기연관학회협의회 2016 Gut and Liver Vol.10 No.4

Background/Aims: We aimed to evaluate the efficacy and safety of an immunosuppressive regimen without steroids after liver transplantation (LT) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods: Sixty-six HCC patients who underwent an immunosuppressive regimen without steroids after LT were enrolled in the steroid-free group. The preoperative characteristics and postoperative outcomes of these patients were compared with those of 132 HCC recipients who were placed on an immunosuppressive regimen using steroids (steroid group). The incidence of acute rejection, HBV recurrence, infection, and new-onset diabetes mellitus and the overall and tumor-free survival rates were compared between the two groups. Results: Differences were not observed in the 1-year (83.3% vs 97.0%, p=0.067), 3-year (65.4% vs 75.8%, p=0.067) or 5-year (56.3% vs 70.7%, p=0.067) patient survival rates or in the 1-year (62.1% vs 72.7%, p=0.067), 3-year (49.8% vs 63.6%, p=0.067) or 5-year (48.6% vs 63.6%, p=0.067) tumor-free survival rates between the two groups, respectively. In the steroid-free group, the patients who fulfilled the Milan criteria had higher overall and tumor-free survival rates than those in the steroid group (p<0.001). The prevalence of HBV recurrence (3.0% vs 13.6%, p=0.02) was significantly lower in the steroid-free group compared with the steroid group. Conclusions: After LT, an immunosuppressive regimen without steroids could be a safe and feasible treatment for HBVrelated HCC patients, thus resulting in the reduction of HBV recurrence. Based on the observed survival rates, patients who fulfill the Milan criteria may derive benefits from steroidfree immunosuppression.

Expression of MiR200a, miR93, Metastasis-related Gene RECK and MMP2/MMP9 in Human Cervical Carcinoma - Relationship with Prognosis

Wang, Ling,Wang, Qiang,Li, He-Lian,Han, Li-Ying Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Aim and Background: Cervical cancer remains the third most common cancer in women globally after breast and colorectal cancer. Well-characterized biomarkers are necessary for early diagnosis and to predict metastatic progression and effective therapy. MiRNAs can regulate gene expression, cell growth, differentiation and apoptosis by targeting mRNAs for translational repression or degradation in tumor cells. The present study was conducted to assess expression of miR93, miR200a, RECK, MMP2, MMP9 in invasive cervical carcinoma, and analyze their clinical significance. Method: A total of 116 patients with invasive cervical carcinoma and 100 patients undergoing hysterectomy for benign lesions were retrospectively examined. Quantitative real-time PCR was performed to determine expression of miR93 and miR200a while RECK, MMP2, MMP9 and MVD were assessed by immunohistochemical staining. Results: Cervical carcinoma patients demonstrated up-regulation of miR-93, miR-200a, MMP2 and MMP9, with down-regulation of RECK as compared to benign lesion tissues. RECK was significantly inversely related to invasion and lymphatic metastasis. The 5-year survival rate for patients with strong RECK expression was significantly higher than that with weakly expressing tumors. Conclusion: MiR-93 and miR-200a are associated with metastasis and invasion of cervical carcinoma. Thus together with RECK they are potential prognostic markers for cervical carcinoma. RECK cooperating with MMP2, MMP9 expression is a significant prognostic factor correlated with long-term survival for patients with invasive cervical carcinoma.

Effects of ultrasonic treatment on the gel properties of microbial transglutaminase crosslinked soy, whey and soy–whey proteins

Qiang Cui,Xibo Wang,Guorong Wang,Rui Li,Xiaodan Wang,Shuang Chen,Jingnan Liu,Lianzhou Jiang 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.5

This paper studied the influences of diverse ultrasonic power treatments on the physico-chemical properties of soy–whey mixed protein induced by microbial transglutaminase. Two groups of 15% (m/v) of protein solution-sole protein (as control group) and mixed protein were prepared and processed under different ultrasonic powers for 30 min. After ultrasonic power treatments, gel properties were significantly increased: under 300 W, the gel hardness of mixed protein reached a maximum of 998.9 g, with its water binding capacity scoring a maximum of 87%. According to the analysis of fluorescence emission spectrum, the fluorescence intensity and maximum absorption peak had changed, for different ultrasonic power treatments had exposed more groups. The Fourier Transform Infrared Spectroscopy also suggested that ultrasonic power treatments could change the secondary structure of gel samples. The scanning electron microscope demonstrated that the network structure of mixed protein gel displayed more regular and uniform after ultrasonic treatments.

Analytical Elasto-plastic Solution for Frost Force of Cold-Region Tunnels considering Anisotropic Frost Heave in the Surrounding Rock

Qiang Feng,Shenggang Fu,Chengxiang Wang,Weiwei Liu,Ying Wang,Weiguo Qiao 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.9

There is an increasing trend of tunnel infrastructure construction in cold regions due to the advance of a western development strategy. To reduce the frost damage sustained by a tunnel, it is important to consider the mechanical properties of frost heave in the surrounding rock by analyzing the anisotropic frost heave of a cold-region tunnel. This paper elaborates on the behavior of anisotropic frost heave in the rock surrounding a cold-region tunnel, and the coefficient of displacement relief is adopted to indirectly quantify the influence of the tunnel construction process. The analytical elasto-plastic solutions of the stress and deformation in the surrounding rock are derived with Drucker-Prager criteria (hereinafter referred to as the D-P criteria) by modifying the constitutive equation for the frozen surrounding rock. Finally, an example is given to obtain the influence law of the distribution of stress and deformation in the surrounding rock. The results indicate that the plastic radius and frost force calculated by considering isotropic frost heave are greater than those obtained by considering anisotropic frost heave. The influence of the related parameters also analyzed. Some useful insights are provided for future numerical simulations and the design and construction of cold-region tunnels.

Resistance to neonicotinoid insecticides and expression changes of eighteen cytochrome P450 genes in field populations of Bemisia tabaci from Xinjiang, China

Wang Qiang,Wang Mei‐Na,Jia Zun‐Zun,Ahmat Tursun,Xie Lin‐Jie,Jiang Wei‐Hua 한국곤충학회 2020 Entomological Research Vol.50 No.4

The occurrence of Bemisia tabaci poses an increasingly serious threat to cotton and vegetable crops in Xinjiang, China. Currently, neonicotinoid insecticides are commonly used to control the insect, to which resistance is inevitable due to intensive use. However, the resistance status and mechanism of B. tabaci to neonicotinoid insecticides in Xinjiang are poorly understood. Cytochrome P450 monooxygenases represent a key detoxification mechanism in the neonicotinoid resistance of B. tabaci. In this study, the resistance level to imidacloprid and thiamethoxam was investigated using the leaf dipping method in five field populations of B. tabaci from Turpan (TP, two sampling sites), Shache (SC), Hotan (HT) and Yining (YN) in northern and southern Xinjiang. The expression changes of eighteen cytochrome P450 genes from the select B. tabaci populations were determined by real-time fluorescence quantitative PCR (qPCR). The bioassay revealed that the five populations tested had developed moderate to high levels of resistance to imidacloprid (12.26–46.07- fold), while the populations remained sensitive to thiamethoxam except for HT, which had a low level of resistance. The qPCR results showed that the expression levels of five P450 genes, CYP4G68, CYP6CM1, CYP303A1-like, CYP6DZ7 and CYP6DZ4, were significantly higher in some resistant field populations than in the susceptible strain. Resistance to imidacloprid in field populations of B. tabaci might be associated with the increased expression of these five cytochrome P450 genes. The results are useful for further understanding the mechanism of neonicotinoid resistance and will contribute to the management of insecticide-resistant B. tabaci in Xinjiang.