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Thakur, Priyanka,Seam, Rajeev Kumar,Gupta, Manoj Kumar,Rastogi, Madhup,Gupta, Manish,Bhattacharyya, Tapesh,Sharma, Mukesh,Revannasiddaiah, Swaroop Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10
Purpose: Blood hemoglobin levels are known to influence response to radiotherapy. This retrospective analysis compared the effect of hemoglobin levels upon response to radiation among patients treated with radiation alone (by accelerated hyperfractionated radiotherapy) versus those treated with concurrent cisplatin chemoradiotherapy. Materials and Methods: Among patients treated for locally advanced carcinoma of the cervix (LACC) during 2009-10, a total of 60 fulfilled the eligibility criteria. In this time frame, external beam radiotherapy was delivered with either concurrent chemoradiotherapy (CRT, n=31) (45Gy over 25 fractions, with weekly cisplatin at 40mg/m2), or with accelerated hyperfractionated radiotherapy (AHRT, n=29) (20Gy over 10 daily fractions over the first two weeks, followed by 30Gy over 20 fractions over the next two weeks, with two fractions of 1.5Gy per day, without the use of chemotherapy). Mean weekly hemoglobin (MWH) levels of all patients were calculated as the arithmetic means of weekly recorded blood hemoglobin levels. As per MWH, patients in both of the AHRT or the CRT groups were classified into two subgroups-those with MWH between 10-10.9g/dL, or with MWH>11g/dL. Complete response (CR) to external beam RT phase (prior to brachytherapy) was declared after clinical examinations and computed tomography. The CR rate was noted for both MWH sub-groups within each of the AHRT and CRT groups. Results: Within the AHRT group, patients with MWH>11g/dL had a much better CR rate in comparison to those with MWH:10-10.9g/dL (80% vs. 21.1%) which was statistically significant (p 0.0045). Within the CRT group, there was no significant difference in the outcomes within the MWH>11g/dL and MWH:10-10.9g/dL sub-groups (CR rates of 80% vs. 61.9%, p=0.4285). Conclusions: The importance of maintaining a minimum hemoglobin level of 11g/dL during RT is much greater for patients treated with RT alone, than for patients treated with concurrent chemoradiotherapy. Enhanced haemoglobin levels during RT may to an extent negate the ill-effects that may otherwise arise due to non-use of concurrent chemotherapy.
Priyanka Thakur,Anika,Rajat Suhag,Atul Dhiman,Satish Kumar 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.4
Black carrots are a type of carrot that is naturally dark purple or black in color. They are a good source of antioxidants, vitamins, and minerals, and have been shown to have several health benefits, including reducing the risk of cancer, heart disease, and diabetes. This review article discusses the bioactive compounds present in black carrot, including anthocyanins, phenolic acids, carotenoids, and organic acids and sugars. It also compares the bioactive compounds and antioxidant capacity of black carrot with other carrot varieties. Furthermore, it discusses various postharvest processing methods, both conventional and novel, such as encapsulation, drying, and microbial decontamination, highlighting their effects on preserving and stabilizing the bioactive compounds. The review also emphasizes the incorporation of black carrot into different food products, including dairy items, beverages, and baked goods, and their impact on nutritional enhancement. The article provides knowledge on utilizing black carrot for improved nutritional and functional outcomes.
Aldose Reductase: a cause and a potential target for the treatment of diabetic complications
Sapna Thakur,Sonu Kumar Gupta,Villayat Ali,Priyanka Singh,Malkhey Verma 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.7
Diabetes mellitus, a disorder of metabolism,results in the elevation of glucose level in the blood. In thishyperglycaemic condition, aldose reductase overexpressesand leads to further complications of diabetes through thepolyol pathway. Glucose metabolism-related disorders arethe accumulation of sorbitol, overproduction of NADH andfructose, reduction in NAD + , and excessive NADPH usage,leading to diabetic pathogenesis and its complications suchas retinopathy, neuropathy, and nephropathy. Accumulationof sorbitol results in the alteration of osmotic pressureand leads to osmotic stress. The overproduction of NADHcauses an increase in reactive oxygen species productionwhich leads to oxidative stress. The overproduction of fructosecauses cell death and non-alcoholic fatty liver disease. Apart from these disorders, many other complications havealso been discussed in the literature. Therefore, the articleoverviews the aldose reductase as the causative agent and apotential target for the treatment of diabetic complications. So, aldose reductase inhibitors have gained much importanceworldwide right now. Several inhibitors, like derivativesof carboxylic acid, spirohydantoin, phenolic derivatives,etc. could prevent diabetic complications are discussedin this article.