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RISS 인기검색어
- 검색키워드
- 저자 : Pratima Verma (검색결과 2 건)
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Krishna, Akhilesh,Singh, R.K.,Singh, Shraddha,Verma, Pratima,Pal, U.S.,Tiwari, Sunita Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Background: Oral cancer is a common form of cancer in India, particularly among men. About 95% are squamous cell carcinomas. Tobacco along with alcohol are regarded as the major risk factors. Objectives: (i) To determine associations of oral squamous cell carcinoma (OSCC) with respect to gender, age group, socioeconomic status and risk habits; (ii) To observe the distribution of affected oral anatomical sites and clinico-pathological profile in OSCC patients. Materials and Methods: This is an unmatched case-control study during period January 2012 to December 2013. Total of 471 confirmed OSCC patients and 556 control subjects were enrolled. Data on socio-demography, risk habits with duration and medical history were recorded. Results: There were significant associations between OSCC with middle age (41-50years; unadjusted OR=1.63, 95%CI=1.05-2.52, p=0.02) (51-60 years; unadjusted OR=1.79, 95%CI=1.15-2.79, p=0.009) and male subjects (unadjusted OR=2.49, 95%CI=1.89-3.27, p=0.0001). Cases with both habits of tobacco chewing and smoking were at a higher risk for OSCC than tobacco chewing alone (unadjusted OR=0.52, 95%CI=0.38-0.72, p=0.0001), duration of risk habits also emerged as a responsible factor for the development of carcinoma. The majority of patients were presented in well-differentiated carcinomas (39.9%). Prevalence of advance stages (TNM stage III, IV) was 23.4% and 18.3% respectively. The buccal mucosa was the most common (35.5%) affected oral site. Conclusions: In most Asian countries, especially India, there is an important need to initiate the national level public awareness programs to control and prevent oral cancer by screening for early diagnosis and support a tobacco free environment.
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Prachi Kumar,Rahul Bhargava,Manoj Kumar,Somesh Ranjan,Manjushri Kumar,Pratima Verma 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.2
Purpose: To establish the strength of the association between routine tear function tests and conjunctival impressioncytology (CIC) and to determine whether they simulate the morphological and cytological changesthat occur on the ocular surface in dry eye. What are the sensitivity, specificity and positive predictive valuesof these tests when CIC is considered the gold standard?Methods: The tear film profile included tear film break up time (TBUT), Schirmer’s-1, Rose Bengal scores (RBS),and impression cytology. CIC samples were obtained from the inferior bulbar conjunctiva and stained withperiodic acid-Schiff and counter stained with hematoxylin and eosin. Results: The mean Schirmer’s value was 11.66 ± 5.90 in patients and 17.17 ± 2.97 in controls (p < 0.001). Themean TBUT in participants was 8.88 ± 3.54 and 13.53 ± 2.12 in controls (p < 0.001). Patients had a meangoblet cell density (GCD) of 490 ± 213, while the value for controls was 1,462 ± 661 (p < 0.001). Abnormal CICwas observed in 46.7% cases of dry eye and in 32.8% of controls. The correlation coefficient (L) for Schirmer’swas 0.2 and 0.24 for participants and controls, respectively, while TBUT values were 0.26 and 0.38, RBSwere 0.5 and 0.5, and GCD was 0.8 and 0.6 in cases and controls, respectively. Conclusions: GCD, RBS, and TBUT were better predictors of morphological and cytological changes in theconjunctiva than Schirmer’s in dry eye syndrome. The sensitivity of tear function tests in diagnosing dry eyewas TBUT > Schirmer’s > RBS, and the specificity was Schirmer’s > TBUT > RBS in decreasing order whenCIC was considered the gold standard.
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