http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Shyam K Mishra ),( Prashant Basukala ),( Om Basukala ),( Keshab Parajuli ),( Bharat M Pokhrel ),( Basista P Rijal ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Microbial biofilms pose great threat for patients requiring indwelling medical devices (IMDs) as it is difficult to eradicate them. Besides, sublethal concentration of some antibiotics has been shown to induce biofilm in bacteria. It is, therefore, crucial to follow an appropriate and relevant method for the detection of biofi lms and hence the clinician can choose appropriate antibiotic for the treatment. Methods: This prospective analysis included 65 prosthetic samples. After isolation and identifi cation of bacteria following standard methodology, antibiogram of the isolates were produced following Kirby-Bauer disk diffusion method. Detection of biofi lms was done by tube adherence (TA), Congo red agar and tissue culture plate (TCP) methods. Results: Out of 67 clinical isolates from indwelling medical devices, TCP detected 31 (46.3%) biofi lm producers and 36 (53.7%) biofi lm non-producers. Klebsiella pneumoniae, Pseudomonas aeruginosa and Burkholderia cepacia complex were found to be the most frequent biofi lm producers. The TA method correlated well with the TCP method for biofi lm detection. Higher antibiotic resistance was observed in biofi lm producers than in biofi lm non-producers. The most effective antibiotics for biofi lm producing Gram-positive isolates were Vancomycin and Tigecycline, and that for biofi lm producing Gram-negative isolates were Polymyxin B, Colistin Sulphate and Tigecycline. Conclusions: Nearly forty-six percent of the isolates were found to be biofi lm producers. The antibiotic susceptibility pattern in the present study showed Amoxicillin to be an ineffective drug for isolates from the IMDs. For the detection of biofi lm production, TA method can be an economical and effective alternative to TCP method.
Akash Kedia,Prashant Kumar Mishra,Abhishek Kumar Dwivedy,Nawal Kishore Dubey,Bhanu Prakash 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.3
The study reports the fumigant, repellent, oviposition deterrent, ovicidal, larvicidal and pupaecidal activities of Cuminum cyminum seed essential oil and its 4 main components (cymene, γ-terpinene, cuminaldehyde and (−)- β-pinene) against Callosobruchus chinensis and Sitophilus oryzae. The essential oil, γ-terpinene and (−)-β-pinene showed pronounced activity in all parameters against both the insects. However, the susceptibility of C. chinensis wasmuch higher than S. oryzae. Cymene and cuminaldehyde showed poormortality to insects but causedmoderate repellency and oviposition deterrency at 100 μl/L air. The essential oil when tested for practical application in protection of food commodities from insect infestation in storage containers, exhibited 100% and 97% feeding deterrent index at 100 μl/L air concentration against C. chinensis and S. oryzae damage respectively without affecting viability of chickpea and wheat. C. cyminum seed essential oil may thus be recommended as eco-friendly and biorational alternatives of synthetic pesticides for management of insect infestation of food commodities.
Management of maxillofacial injuries in bear mauling cases: a review of 20 cases
Indu Bhusan Kar,Prashant Dilip Chopda,Niranjan Mishra,Alok Kumar Sethi,Bikas Ranjan Mahavoi 대한구강악안면외과학회 2016 대한구강악안면외과학회지 Vol.42 No.1
Objectives: As the craniofacial and neck regions are prime areas of injury in bear attacks, the careful management of soft and hard tissue injuries and selection of reconstructive options is of the utmost importance. This study will review the incidence and patterns of bear mauling in eastern India reported to our department and the various modalities used for their treatment over a period of 7 years. It also documents the risks of infection in bear mauling cases and the complications that have occurred. Materials and Methods: Twenty cases were treated over the study period. Cases were evaluated for soft and hard tissue injuries including tissue loss and corresponding management in the craniofacial region. Cases were also evaluated for other associated injuries, organ damage and related complications. Results: Various modalities of treatment were used for the management of victims, ranging from simple primary repairs to free tissue transfers. Simple primary repairs were done in 75% of cases, while the management of the injured victims required reconstruction by local, regional or distant flaps in 25%. Free tissue transfers were performed in 15% of cases, and no cases of wound infection were detected in the course of treatment. Conclusion: Knowledge of various reconstructive techniques is essential for managing maxillofacial injuries in bear mauling cases. Modern reconstructive procedures like free tissue transfer are reliable options for reconstruction with minimal co-morbidity and dramatic improvement in treatment outcomes.
Kim, Saegun,Chakrasali, Prashant,Suh, Hyo Sun,Mishra, Neeraj Kumar,Kim, Taeyoung,Han, Sang Hoon,Kim, Hyung Sik,Lee, Byung Mu,Han, Soo Bong,Kim, In Su American Chemical Society 2017 Journal of organic chemistry Vol.82 No.14
<P>The aldimine-directed C-H amidation of various arenes with N-acyl azides as amidation surrogates under cationic iridium(III) catalysis is described. This transformation efficiently provides a range of 2-aminobenzaldehyde derivatives with excellent site selectivity and functional group compatibility. The resulting 2-aminobenzaldehyde framework provides facile access to a range of biologically interesting heterocycles. In addition, all synthetic compounds were screened for anti-inflammatory activity against interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) with lipopolysaccharide (LPS)-induced RAW264.7 cells. Generally, a range of ortho-amidated benzaldehydes displayed promising inhibitory activity against IL-1 beta and TNF-alpha compared to dexamethasone as a positive control. Notably, compounds (3ae and 4ac) were found to exhibit potent anti-inflammatory activity stronger than that of dexamethasone.</P>
Chanchal Das,Narendra Nath Ghosh,Ritu Bhardwaj,Kritika Narula,Prashant Mishra,Goutam Biswas 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
Every year, due to usage, overproduction, and overprescribing, a huge amount of pharmaceutical wasteaccumulates. Among these, hydrocortisone (a corticosteroid) has lately been popular for COVID-19 therapy. Hence, removal of these pollutants by efficient, cheaper and greener way is needed. The photocatalyticdegradation of hydrocortisone by nanoparticles has yet to be investigated. In this study, thehydro-alcoholic extract of Nigella sativa seeds coated magnetite nanoparticles (NS@MNPs) was synthesizedas a low-cost, sustainable photocatalyst to degrade hydrocortisone from simulated wastewater. At neutral pH, the highest degradation percentage 97.1% was achieved with 15 mg of NS@MNPs within540 min for a 10 mL 60 mg/L of hydrocortisone solution. Experimentally, it was observed that the degradationwas more specific at 254 nm irradiation. The mechanism of degradation was established by scavengingexperiments, density functional theory (DFT) calculations, and liquid chromatography-massspectroscopy analysis of the treated simulated wastewater. Due to the presence of naturally occurringions, the degradation of hydrocortisone by NS@MNPs in the surface water was reduced. FTIR spectra after12th cycle revealed that the coating of NS@MNPs remains unchanged, thus increasing recyclability. NS@MNPs were also proved to be nontoxic towards NIH/3T3 normal cells at micromolar concentrations,demonstrating its vast applicability.
Morin ameliorates myocardial injury in diabetic rats via modulation of inflammatory pathways
Vipin Kumar Verma,Salma Malik,Ekta Mutneja,Anil Kumar Sahu,Vaishali Prajapati,Prashant Mishra,Jagriti Bhatia,Dharamveer Singh Arya 한국실험동물학회 2024 Laboratory Animal Research Vol.40 No.1
Background: High blood glucose levels in diabetes lead to vascular inflammation which accelerates atherosclerosis. Herein, Morin was orally administered in male Wistar rats, at the dose of 40 mg/kg for 28 days, and on the 27th and 28th day, ISO was administered to designate groups at the dose of 85 mg/kg s.c., to induce myocardial infarction. Results: Free radical generation, including ROS, in diabetes following ISO administration, leads to the activation of both intrinsic and extrinsic pathways of apoptosis. Morin significantly (p ≤ 0.05) reduced oxidative stress (GSH, MDA, SOD), cardiac injury markers (CK-MB, LDH), inflammation (TNF, IL-6), and apoptosis (Bax, BCl2, Caspase-3). In addition, it also reduced insulin and blood glucose levels. Akt/eNOS, Nrf2/HO-1, MAPK signaling pathways, and Insulin signal transduction pathways were positively modulated by morin pre-treatment. Conclusions: Morin attenuated oxidative stress and inflammation and also modified the activity of various molecular pathways to mitigate cardiomyocyte damage during ISO-induced MI in diabetic rats.