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RISS 인기검색어
- 검색키워드
- 저자 : ( Shyam K Mishra ) (검색결과 3 건)
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( Shyam K Mishra ),( Prashant Basukala ),( Om Basukala ),( Keshab Parajuli ),( Bharat M Pokhrel ),( Basista P Rijal ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Microbial biofilms pose great threat for patients requiring indwelling medical devices (IMDs) as it is difficult to eradicate them. Besides, sublethal concentration of some antibiotics has been shown to induce biofilm in bacteria. It is, therefore, crucial to follow an appropriate and relevant method for the detection of biofi lms and hence the clinician can choose appropriate antibiotic for the treatment. Methods: This prospective analysis included 65 prosthetic samples. After isolation and identifi cation of bacteria following standard methodology, antibiogram of the isolates were produced following Kirby-Bauer disk diffusion method. Detection of biofi lms was done by tube adherence (TA), Congo red agar and tissue culture plate (TCP) methods. Results: Out of 67 clinical isolates from indwelling medical devices, TCP detected 31 (46.3%) biofi lm producers and 36 (53.7%) biofi lm non-producers. Klebsiella pneumoniae, Pseudomonas aeruginosa and Burkholderia cepacia complex were found to be the most frequent biofi lm producers. The TA method correlated well with the TCP method for biofi lm detection. Higher antibiotic resistance was observed in biofi lm producers than in biofi lm non-producers. The most effective antibiotics for biofi lm producing Gram-positive isolates were Vancomycin and Tigecycline, and that for biofi lm producing Gram-negative isolates were Polymyxin B, Colistin Sulphate and Tigecycline. Conclusions: Nearly forty-six percent of the isolates were found to be biofi lm producers. The antibiotic susceptibility pattern in the present study showed Amoxicillin to be an ineffective drug for isolates from the IMDs. For the detection of biofi lm production, TA method can be an economical and effective alternative to TCP method.
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Successful Superovulation and Recovery of Embryos in Repeat Breeding Crossbred Cows
Zawar, Shyam,Mishra, U.K.,Gaswade, P.G. 韓國受精卵移植學會 2002 한국동물생명공학회지 Vol.17 No.3
The present study was undertaken to find out possibilities for superovulation and recovery of freezable/transferable embryo from repeat breeding crossbred cows. For this study a total of 10 Holstein crossbred cows having history of failure of conception even after more than 4~5inseminations were taken and superovulated using Folltropin-V at 100 to 140% dose schedule. The results indicated that out of 10 donors, 8 responded to superovulatory treatment and yielding a total of 94 embryos, out of which 45 were of transferable/freezable quality. The mean ovulations and mean transferable embryos were 11.52.91 and 4.51.66, respectively. These observations suggests that the repeat breeding cows having conception failure after several artificial inseminations can be used as donors for production of embryos and calves through embryo transfer technology.
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Nanotechnology in reproductive medicine: Opportunities for clinical translation
Shandilya, Ruchita,Pathak, Neelam,Lohiya, Nirmal Kumar,Sharma, Radhey Shyam,Mishra, Pradyumna Kumar The Korean Society for Reproductive Medicine 2020 Clinical and Experimental Reproductive Medicine Vol.47 No.4
In recent years, nanotechnology has revolutionized global healthcare and has been predicted to exert a remarkable effect on clinical medicine. In this context, the clinical use of nanomaterials for cancer diagnosis, fertility preservation, and the management of infertility and other pathologies linked to pubertal development, menopause, sexually transmitted infections, and HIV (human immunodeficiency virus) has substantial promise to fill the existing lacunae in reproductive healthcare. Of late, a number of clinical trials involving the use of nanoparticles for the early detection of reproductive tract infections and cancers, targeted drug delivery, and cellular therapeutics have been conducted. However, most of these trials of nanoengineering are still at a nascent stage, and better synergy between pharmaceutics, chemistry, and cutting-edge molecular sciences is needed for effective translation of these interventions from bench to bedside. To bridge the gap between translational outcome and product development, strategic partnerships with the insight and ability to anticipate challenges, as well as an indepth understanding of the molecular pathways involved, are highly essential. Such amalgamations would overcome the regulatory gauntlet and technical hurdles, thereby facilitating the effective clinical translation of these nano-based tools and technologies. The present review comprehensively focuses on emerging applications of nanotechnology, which holds enormous promise for improved therapeutics and early diagnosis of various human reproductive tract diseases and conditions.
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