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Macromolecular Docking Simulation to Identify Binding Site of FGB1 for Antifungal Compounds
Prabhakaran Soundararajan,정병룡,Iyyakkannu Sivanesan,Sugunadevi Sakkiah,이근우 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.10
Fusarium oxysporum, an important pathogen that mainly causes vascular or fusarium wilt disease which leads to economic loss. Disruption of gene encoding a heterotrimeric G-protein-β-subunit (FGB1), led to decreased intracellular cAMP levels, reduced pathogenicity, colony morphology, and germination. The plant defense protein, Nicotiana alata defensin (NaD1) displays potent antifungal activity against a variety of agronomically important filamentous fungi. In this paper, we performed a molecular modeling and docking studies to find vital amino acids which can interact with various antifungal compounds using Discovery Studio v2.5 and GRAMMX,respectively. The docking results from FGB1-NaD1 and FGB1-antifungal complexes, revealed the vital amino acids such as His64, Trp65, Ser194, Leu195, Gln237, Phe238, Val324 and Asn326, and suggested that the anidulafungin is a the good antifungal compound.The predicted interaction can greatly assist in understanding structural insights for studying the pathogen and host-component interactions.
Prabhakaran Soundararajan,Abinaya Manivannan,고정호,박지은,Byoung Ryong Jeong 한국원예학회 2019 Horticulture, Environment, and Biotechnology Vol.60 No.2
Addressing the deterioration eff ects due to chlorine salt use as an anti-freezing agent to prevent the deposition of ice onroads during heavy snowfall is a serious issue to protect the ecosystem. Therefore, the present study was conducted to determinethe eff ects caused by deicing agents on three diff erent creeper plant species that commonly grow on roadsides, suchas Trachelospermum asiaticum , Euonymus fortunei , and Gelsemium sempervirens . The two chlorine salts calcium chloride(CaCl 2 ) and magnesium chloride (MgCl 2 ) were applied to plants either as a splash or spray in diff erent concentrations atdiff erent intervals. After 6 days of treatments, the results suggested that application of both CaCl 2 and MgCl 2 aff ected thechlorophyll content and physiological processes of the creepers in a dose-dependent manner. Further analysis of oxidativestress related parameters such as lipid peroxidation, superoxide, and hydrogen peroxide content showed that both CaCl 2 andMgCl 2 aff ected redox homeostasis. While the application of deicing agents induced the activities of antioxidant enzymes,they also decreased the content of ascorbate and proline, which are effi cient osmolytes, in the dose-dependent manner. Nevertheless,comparatively oxidative stress induced by CaCl 2 is higher than the MgCl 2 in all three creeper-type plants includedin our analysis; still the frequent application and higher concentration of both deicing agents interrupt the growth of roadsidevegetation. Despite the relative toxicity of the deicers, T. asiaticum was aff ected lesser than E. fortunei and G. sempervirens .
Silicon Promotes Shoot Proliferation and Shoot Growth of Salvia splendens under Salt Stress in Vitro
Prabhakaran Soundararajan,Iyyakkannu Sivanesan,조은혜,정병룡 한국원예학회 2013 Horticulture, Environment, and Biotechnology Vol.54 No.4
Silicon (Si) is known to have beneficial effects on plants especially in monocots such as rice, wheat, and sugarcane. The objective of this study was to examine the effect of Si against NaCl on axillary shoot proliferation and shoot growth of in vitro of Salvia splendens ‘Hot Jazz’, one of the important floricultural plants. In vitro study was chosen because in such controlled environment the mechanism of Si alleviation can be clearly studied without any external hindrance. Nodal explants have been cultured on the MS medium supplemented with 3.0 mg·L-16-benzylaminopurine (BAP) and 0.5 mg·L-1 indole-3-acetic acid (IAA) with or without 50 or 100 mM NaCl as the salt stress source and 50 or 100 mg·L-1 K2SiO3 as the Si source. Salt stress exhibited strong retardation on growth parameters such as number and length of shoots and internodes, chlorophyll content, and the fresh and dry weights of shoots. At 50 mM NaCl both 50 and 100 mg·L-1 K2SiO3 helped to overcome the salt effect and maximized the plant growth. Though the Si gave tolerance and increased growth even in the 100 mM NaCl treatment, it was not as much effective as in the 50 mM NaCl treatment. In conclusion, these results put forward an experimental evidence for further studies of Si on salinity stress in ornamental plants.