"不+能+沒(有)+Vp1+就+Vp2"構式硏究

彭利貞,宋永圭 中國語文硏究會 2003 中國語文論叢 Vol.25 No.-

본 연구는 “不+能+沒(有)+Vp1+就+Vp2”구조를 분석하는데 목적이 있다. 본문에서는 발화(혹은 문장)에서 정태가 명제의 외부를 감싸고 있음을 가정하고, 명제부분과 정태부분과의 관계에 주목하고 또한 사건“沒Vp1”(혹은“Vp1”) 와 “Vp2”의 관계를 분석하였다. 정태(Modality)는 본질적으로 문맥구속(Context Bounded)적인 범주이므로 그 의미의 파악은 문맥을 파악하므로 그 정확한 쓰임을 알 수 있는바, 본문은 대화참여자의 변화와 시간참조점 (Temporal Deixis)의 변화가 정태동사“能”의 의미현상에 미치는 영향을 분석하였다. 당 어법구조는 이중부정 구조이며, 그 의미는 긍정이고, 부정사“不”의 부정범위는 전체 명제에 미치고, 부정의 초점은 정태부분이다. 沒의 부정의 범위는 “Vp1”으로 제한된다. 본문은 또한 “沒(有)Vp1” 와 “Vp2”의 관계를 논증하면서 두 사건은 의미상 연관된 사건이며 시간적으로는 연속적이라는 특성이 있음을 밝혔고, 본 구조의 주어는 일반적으로 [+生命]의 특징을 지니고 사건 “沒(有)Vp1” 와 “Vp2”는 일반적으로 동일한 주어를 가짐을 보였다.

Alkaloids from Lycoris caldwellii and their particular cytotoxicities against the astrocytoma and glioma cell lines

Peng Cao,Dong-Sheng Pan,Song Han,Chun-Yong Yu,Qing-Jie Zhao,Yan Song,Yong Liang 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.8

Phytochemical investigation of the ethanolextract of the bulbs of Lycoris caldwellii afforded fournew alkaloids, (?)-N-methoxylcarbonyl-nandigerine (1),(?)-N-methoxycarbonyl-lindcarpine (2), (?)-10-O-methylhernovineN-oxide (3), and (?)-3-hydroxy-anhydrolycorineN-oxide (4). Structural elucidation of all the compounds wereperformed by spectral methods such as 1D and 2D (1H-1HCOSY, HMQC, and HMBC) NMR spectroscopy, in additionto high resolution mass spectrometry. All the alkaloids werein vitro evaluated for their cytotoxic activities against eighttumor cell lines (BEN-MEN-1, CCF-STTG1, CHG-5, SHG-44, U251, BGC-823, HepG2, and SK-OV-3). Alkaloids 1and 2 exhibited particular cytotoxic activities against astrocytomaand glioma cell lines with IC50 of 9.2–11.3 lM and10.4–12.2 lM respectively.

Real-Time Tumor Gene Expression Profiling to Direct Gastric Cancer Chemotherapy: Proof-of-Concept “3G” Trial

Yong, Wei Peng,Rha, Sun Young,Tan, Iain Bee-Huat,Choo, Su-Pin,Syn, Nicholas L.,Koh, Vivien,Tan, Shi-Hui,Asuncion, Bernadette Reyna,Sundar, Raghav,So, Jimmy Bok-Yan,Shabbir, Asim,Tan, Chee-Seng,Kim, Hy American Association for Cancer Research 2018 Clinical Cancer Research Vol.24 No.21

<P><B>Purpose:</B> The oxaliplatin plus S-1 and cisplatin plus S-1 regimens are interchangeably used in the management of advanced gastric cancer. The previously reported G-intestinal (G1) and G-diffuse (G2) intrinsic gene expression signatures showed promise for stratifying patients according to their tumor sensitivity to oxaliplatin or cisplatin.</P><P><B>Experimental Design:</B> The proof-of-concept, multicenter, open-label phase II “3G” trial was done to prospectively evaluate the feasibility and efficacy of using genomic classifiers to tailor treatment in gastric cancer. Patients’ tumors were classified as “G1” or “G2” using a nearest-prediction template method, or “G3” (unclear assignment) when FDR ≥ 0.05. The first 30 patients in the “G1” cohort were assigned oxaliplatin plus S-1 (SOX) chemotherapy; thereafter, subsequently recruited “G1” patients were treated with cisplatin plus S-1 (SP) chemotherapy. “G2” patients and “G3” patients were treated with SP and SOX chemotherapy, respectively.</P><P><B>Results:</B> A total of 48, 21, and 12 patients, respectively, were given “G1,” “G2,” and “G3” genomic assignments. Median turnaround time was 7 days (IQR, 5–9). Response rates were 44.8%, 8.3%, 26.7%, and 55.6% for the “G1-SOX,” “G1-SP,” “G2,” “G3” cohorts, respectively; and was higher in G1 patients treated with SOX compared with SP (<I>P</I> = 0.033). Exploratory analyses using the genomic classifier of Lei and colleagues validated the utility of the metabolic signature as a biomarker for predicting benefit from chemotherapy (log-rank <I>P</I> = 0.004 for PFS), whereas the Asian Cancer Research Group classifier did not demonstrate any predictive value.</P><P><B>Conclusions:</B> This bench-to-bedside effort establishes a reasonable turnaround time for gene expression profiling and possible utility of genomic classifiers in gastric cancer treatment stratification. <I>Clin Cancer Res; 24(21); 5272–81. ©2018 AACR</I>.</P>

Structural Damage Identification Based on Convolutional Neural Network Group Considering the Sensor Fault

Yong-Peng Luo,Linkun Wang,Xu Guo,Jinlin Zheng,Fei-Yu Liao,Zixiong Guo 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.8

This article proposes a structural damage identification method based on one-dimensional convolutional neural network group considering sensor faults. The method aims to reduce the damage misjudgment caused by sensor faults. In the proposed method, according to the sensor layout, some convolutional neural network sub-models are established to extract the features from raw vibration data for sensor fault diagnosis and structural damage identification; then two convolutional neural networks groups, namely the sensor fault diagnosis group and the damage identification group are designed on the basis of the functions of each sub-model. The sensor fault diagnosis group determines whether the sensor data is abnormal and truncates the abnormal signal. The remaining normal signal are entered into the damage identification group and the final damage identification results are calculated according to the statistical decision module. The effectiveness of the devised method is verified by the IASC–ASCE benchmark structure and laboratory experiments. The results demonstrate that the sensor fault diagnosis and damage identification accuracy of each sub-model ranges from 98.54% to 99.77% and from 87.21% to 91.74% respectively at different noise levels; the damage identification group can reduce the impact of sub-model misjudgment on the structural damage identification. The accuracy of the final damage identification results is 100%. The identification time of all samples in the test set is 53.09 s and 22.93 s, respectively, for SHM benchmark and Laboratory experiment cases. And the average judgment time of each submodel in the sensor fault diagnosis group was 278 and 94 ms, and that of each submodel in the damage identification group was 294 and 105 ms, respectively, for a single test sample, which fulfills the requirements of online damage identification for structural health monitoring.

Immune and Anti-oxidant Functions of Ethanol Extracts of Scutellaria baicalensis Georgi in Mice Bearing U14 Cervical Cancers

Peng, Yong,Guo, Cong-Shan,Li, Pan-Xia,Fu, Zhan-Zhao,Gao, Li-Ming,Di, Ya,Ju, Ya-Kun,Tian, Ru,Xue, Jia-Jia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10

Background: The objective was to study the effect of Scutellaria baicalensis Georgi ethanol extracts (SBGE) on immune and anti-oxidant function in U14 tumor-bearing mice. Materials and Methods: U14 tumor-bearing mice were randomly divided into eight groups: a control group, a cyclophosphamide (CTX) group, three dose groups of SBGEI (high, medium, low), and three dose groups of SBGEII (high, medium, low). After two weeks, the thymus and spleen weight indices of mice bearing U14 cervical cancer were calculated. Enzyme linked immunosorbent assays (ELISA) was used to determine the levels of serum IL-2, TNF-${\alpha}$, IL-8, and PCNA. MDA activity and SOD activity in plasma were measured with detection kits. Results: In the SBGE groups, thymus weight and spleen weight indices of U14 tumor-bearing mice were significantly higher than in the control group or CTX group (p<0.05). Compared to control group, the levels of serum IL-2 and TNF-${\alpha}$ in U14 tumor-bearing mice increased significantly, whereas the contents of serum IL-8 and PCNA decreased (p<0.05). The activity of SOD increased with the growing dose of SBGE, while the activity of MDA decreased significantly in the highe-rdose groups of SBGE. Conclusions: These findings suggested that SBGE, especially at high dose, 1000 mg/kg, showed significant immune and anti-oxidant effects infU14 tumor-bearing mice, which might be the mechanisms of SBGE inhibition of tumor growth.

Optimal inspection frequency to mitigate the risk of building system failure

Cheong Peng Au-Yong,Azlan Shah Ali,Faizah Ahmad,Shirley Jin Lin Chua 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.64 No.3

The poor maintenance practice increases the possibility of system failure. Subsequently, the consequences of failure fall on the aspects of output, safety and healthy, environmental integrity, system quality, and customer satisfaction. Conditionbased maintenance is seen as a potential strategy to improve performance. Whereby, the key success factor of this maintenance strategy is identified as the system inspection. This study aims to investigate the association between system breakdown rate and frequency of inspection. A mixed method approach is implemented by distributing questionnaire and interviewing for data collection. Subsequently, descriptive analysis, correlation analysis and regression are adopted to analyse the collected data from 100 respondents and the results are validated with interview data of 10 interviewees. The research result establishes significant relationship between the system breakdown rate and the frequency of inspection. Additionally, the result of regression analysis confirms that the frequency of inspection is the significant predictor of system breakdown rate. Planning of accurate inspection frequency is crucial to secure the system performance. Hence, the research signifies the importance to carry out regular inspection towards the building systems and components. As a recommendation, the maintenance personnel should assess the risk criticality of the building systems. Then, continuously monitor the condition of critical building systems; regularly inspect the condition of non-critical building systems and randomly inspect all of them.

Macrophages Promote Coal Tar Pitch Extract-induced Tumorigenesis of BEAS-2B Cells and Tumor Metastasis in Nude Mice Mediated by AP-1

Zhang, Peng,Jin, Yue-Fei,Zhang, Qiao,Wu, Yi-Ming,Wu, Wei-Dong,Yao, Wu,Wu, Yong-Jun,Li, Zhi-Tao,Zhao, Yong,Liu, Yu,Feng, Fei-Fei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12

Background: We sought to evaluate the role of tumor associated macrophages (TAMs) on the promotion of coal tar pitch extract (CTPE)-induced tumorigenesis of human bronchial epithelial cells (BEAS-2B) and tumor metastasis in nude mice, and related mechanisms. Materials and Methods: BEAS-2B cells were first treated with 2.4 mg/mL CTPE for 72 hours. After removal of CTPE, the cells were continuously cultured and passaged using trypsin-EDTA. THP-1 cells were used as macrophage-like cells. BEAS-2B cells under different conditions (n=6/group) were injected into the back necks of nude mice, and alterations of tumor xenograft growth, indicative of tumorigenicity, and tumor metastasis were determined. Pathological changes (tumor nests and microvascular lesions) of HE-stained tumor tissues were also evaluated. The expression of AP-1(c-Jun) in xenografts and metastatic tumors was determined using immunohistochemistry. Results: Tumor size and weight in nude mice transplanted with the mixture of CTPE-induced passage 30 BEAS-2B and THP-1 cells (2:1) were increased compared to those from the CTPE-treated BEAS-2B cells at passage 30 alone at different observation time points. Tumor metastasis to lymph nodes and liver was only detected after transplantation of a mixture the two kinds of cells. The numbers of tumor nests and microvascular lesions, and the expression levels of AP-1 (c-Jun) in tumors from the mixture of two kinds of cells were increased apparently in contrast to those in tumor from the CTPE-treated BEAS-2B cells of passage 30 alone. In addition, there was positive correlation between AP-1 (c-Jun) expression level and the number of microvascular lesions, or between AP-1 (c-Jun) expression level and tumor metastasis in these two groups. Conclusions: TAMs not only facilitate tumorigenesis transformation of CTPE-induced BEAS-2B cells, but also promote tumor growth, angiogenesis and metastasis in nude mice in vivo, which may be mediated by AP-1.

Blast diseases influenced on agronomic and eating quality traits of rice in Korea

Feng-peng Li,Won-Hee Ra,Yong-Jin Park,Il-Pyung Ahn 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07

Rice (Oryza sativa L.) is one of the most important staple foods that feed more than 50% of the world’s population. With the improving of people’s living standard, eating quality of rice become the most important aims in current breeding programs. Amylose content (AC) and gelatinization temperature (GT) are the two main measures to estimate the rice grain quality. In rice, a total of 27 genes directly involved the rice starch biosynthesis effecting on the rice eating quality. It clearly identified chromosome 6 to be rich in the genes related to AC and GT properties (GBSS I, SSIIa and SBE I) along with other genomic regions scattered in rice genome. Rice blast, caused by the fungal pathogen M. oryzae, is the most devastating disease of rice and severely affects crop stability and sustainability worldwide. Many fungal genes involved in pathogenicity and rice genes involved in effector recognition and defense responses have been identified over the past decade. A total of 99 and 22 blast resistance genes have been identified and cloned; in which 45% were found in japonica cultivars, 51% in indica cultivars, and the rest 4% in wild rice species. Among them, three major resistance gene clusters have been characeterized: the Pik locus on Chromosome 11, and the Pita locus on Chromosome 12, the Piz locus on Chromosome 6 closely to the starch synthesis-related genes. These results could be important clues for studying the relationship between resistance / susceptible materials and eating quality.

Selective Improvement of NO₂ Gas Sensing Behavior in SnO₂ Nanowires by Ion-Beam Irradiation

Kwon, Yong Jung,Kang, Sung Yong,Wu, Ping,Peng, Yuan,Kim, Sang Sub,Kim, Hyoun Woo American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.21

<P>We irradiated SnO2 nanowires with He ions (45 MeV) with different ion fluences. Structure and morphology of the SnO2 nanowires did not undergo noticeable changes upon ion-beam irradiation. Chemical so, equilibrium in SnO2/gas systems was calculated from thermodynamic principles, which were used to study the sensing selectivity of the tested gases, demonstrating the selective sensitivity of the SnO2 surface to NO2 gas. Being different from other gases, including H-2, ethanol, acetone, SO2, and NH3, the sensor response to NO2 gas significantly increases as the ion fluence Acetone increases, showing a maximum under an ion fluence of 1 X 10(16) ions/cm(2). Photoluminescence analysis shows that the relative intensity of the peak at 2.1 eV to the peak at 2.5 eV increases upon ion-beam irradiation, suggesting that structural defects and/or tin interstitials have been generated. X-ray photoelectron spectroscopy indicated that the ionic ratio of Sn2+/Sn4+ increases by the ion-beam irradiation, supporting the formation of surface Sn interstitials. Using thermodynamic calculations, we explained the observed selective sensing behavior. A molecular level model was also established for the adsorption of NO2 on ion-irradiated SnO2 (110) surfaces. We propose that the adsorption of NO2-related species is considerably enhanced by the generation of surface defects that are comprised of Sn interstitials.</P>

Life Science : Obovatol improves cognitive functions in animal models for Alzheimer`s disease

( Dong Yong Chou ),( Jae Woong Lee ),( Jin Peng ),( Young Jung Lee ),( Jin Peng ),( Young Jung Lee ),( Jin Yi Han ),( Yeon Hee Lee ),( Im Seop Choi ),( Sang Bae Han ),( Jae Kyung Jung ),( Woong Soo Le 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0

Etiology of Alzheimer`s disease (AD) is obscure, but neuroinflammation and accumulation of β-amyloid (Aβ) are implicated in pathogenesis of AD. We have shown anti-inflammatory and neurotrophic properties of obovatol, a biphenolic compound isolated from Magnolia obovata. In this study, we examined the effect of obovatol on cognitive deficits in two separate ADmodels: (i) mice that received intracerebroventricular (i.c.v.) infusion of Aβ(1-42) (2.0 μg/mouse) and (ii) Tg2576 mice-expressing mutant human amyloid precursor protein (K670N, M671L). Injection of Aβ(1-42) into lateral ventricle caused memory impairments in the Morris water maze and passive avoidance tasks, being associated with neuroinflammation. Aβ(1-42) -induced abnormality was significantly attenuated by administration of obovatol. When we analyzed with Tg2576 mice, long-term treatment of obovatol (1 mg/kg/day for 3 months) significantly improved cognitive function. In parallel with the improvement, treatment suppressed astroglial activation, BACE1 expression and NF-κB activity in the transgenic mice. Furthermore, obovatol potently inhibited fibrillation of Aβin vitro in a dose-dependent manner, as determined by Thioflavin T fluorescence and electron microscopic analysis. In conclusion, our data demonstrated that obovatol prevented memory impairments in experimental AD models, which could be attributable to amelioration of neuroinflammation and amyloidogenesis by inhibition of NF-κB signaling pathway and anti-fibrillogenic activity of obovatol.