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Jin-Yi Han3*, Xu Zi Guang, Jyung-Sik Kwak, Ki-Wan Oh, Han-Ik Bae 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1
The anti-inflammatory effect of PHBV/Collagen (PHCP) was examined in a mouse model of lipopolysaccharide (LPS)-induced skin inflammation. Vascular permeability on the back skin was measured by the local accumulation of Evan’s blue dye after subcutaneous injection of LPS (30 μg site-1). Dye leakage in the skin showed a significant increase at 2 h after injection of LPS. This LPS-induced dye leakage was also completely inhibited by HO-1 inhibitor, ZnPP, and antioxidants, including methyl gallate, trolox, and mannitol. To study the possible mechanisms underlying the in vivo anti-inflammatory effect of PHCP against LPS-induced inflammation, we also examined the effects of PHCP on malondialdehyde (MDA) and glutathione levels in skin tissues and found that pretreatment with PHCP resulted in inhibited MDA elevation and a remarkable reduction of glutathione level. In addition, similar results were obtained after pretreatment with antioxidants, including trolox and mannitol, and HO-1 inhibitor, ZnPP. Histopathologically, an influx of neutrophils into the skin dermis was detected between 24 h and 72 h after LPS injection (30, 100 μg site-1), compared to control animals after injection of saline. This increase was greater in mice treated with 100 μg of LPS than in those treated with 30 μg of LPS and was significantly suppressed by pretreatment with PHCP, antioxidants, and HO-1 inhibitor. These results collectively suggest that PHCP has an anti-inflammatory effect against LPS-induced inflammation model in vivo and may be a good candidate for the skin tissue engineering biomedical application primarily through manipulation of the redox state.
An Jin,Xuelian Xiang,Yun-Yun Zhu,Heng-Yi Yu,Hui-Fang Pi,Peng Zhang,Han-Li Ruan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Three new alkaloids, 2a-hydroxy-6-O-n-butyloduline,O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine(1–3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-20-methylbenzene-30,60-diol (14), along with ten known alkaloids (4–13), wereisolated from the bulbs of Lycoris aurea collected fromHuaihua County of Hunan Province, China. Their structureswere elucidated by spectroscopic methods includingHRESIMS, UV, IR, and NMR. All the isolated compoundswere tested for their neuroprotective effects against CoCl2and H2O2-induced SH-SY5Y cell death. Compounds 1–7and 10 exhibited significant neuroprotective effects againstCoCl2-induced SH-SY5Y cell injury, while compounds1–5, 7, 10 and 12 showed obvious neuroprotective effectsagainst H2O2-induced SH-SY5Y cell death.
최연주 ( Choi Yeon-joo ),전진이 ( Jun Jin-yi ),한홍익 ( Han Hong-ik ) 한국밀교학회 2022 불교학밀교학연구 Vol.1 No.-
『남양선생시집』은 고려 무인집권기에 문신관료였던 백분화의 시집이다. 그는 스스로 參禪居士라 할 정도로 禪法을 좋아하였다. 이 시집은 백분화의 장남인 희심이 간행을 주도하였다. 승려이자 문인이었던 희심은 부친이 생전에 남긴 시 2백여 首를 수습해 上下卷으로 편찬하고, 제목과 서문을 이규보 아들인 이함에게 의뢰하였다. 백분화는 이규보보다 나이가 10살 적었지만 일찍 出仕하였다. 최씨정권과 밀착되었던 백분화는 이규보의 출사를 위해 다방면으로 도움을 주었을 것이다. 이는 두 사람이 주고 받은 詩와 이규보가 지은 백분화의 묘지명을 통해 충분히 짐작할 수 있다. 이러한 두 사람의 관계는 아들인 희심과 이함에게 자연스럽게 이어져 시집의 제목과 서문 작성 배경이 되었을 것이다. 『남양선생시집』은 『고려대장경』 조성사업이 마무리된 직후인 고종 36년(1249)에 간행되었다. 시집에서 惠堅과 孝眞이라는 각수가 조사되었는데, 이들은 『고려대장경』 판각에 참여한 각수이다. 시집 간행이 『고려대장경』 판각과 밀접하게 연관되어 있음을 보여준다. 『남양선생시집』 간행 과정을 검토해 보면 이규보의 『동국이상국집』 간행과 유사한 점이 많다. 그렇다면 『고려대장경』 조성사업의 체계를 활용하여 분사대장도감(이하 분사도감으로 약칭함)에서 『남양선생시집』을 간행하였을 개연성이 매우 높다. 『Namyang Seonsaeng Sijib』(『南陽先生詩集』) is a collection of Beak Bunhwa(白賁華) in a period of the Choi military regime. He had continuously interchanged with the Buddhist community including reputed monks. 『Namyang Seonsaeng Sijib』 was published by monk Huisim(希諗), the eldest son of Beak Bunhwa. Twenty-five years after the death of his father, Huisim had collected scattered poems and compiled them into two volumes. Yi Ham(李涵), the son of Yi Gyubo(李奎報), wrote the preface of it. Likewise, Yi Gyubo wrote the epitaph of Beak Bunhwa. Beak Bunhwa and Yi Gyubo were deeply involved in politics and literature. To sum up this causality, these two families had a quite friendly relationship. Meanwhile, 『Namyang Seonsaeng Sijib』 was released immediately after the engraving of 『Tripitaka Koreana』. Hyegyeon(惠堅) and Hyojin(孝眞), engravers who participated in the engraving 『Tripitaka Koreana』, undertook repeatedly the editing of 『Namyang Seonsaeng Sijib』. It shows that publication of 『Namyang Seonsaeng Sijib』 and engraving of 『Tripitaka Koreana』 are closely linked. Beak Bunhwa and Yi Gyubo are politicians who cooperated with the Choi military regime. As 『Donggukyisanggukjip』(『東國李相國集』), the collection of Yi Gyubo, was produced in Bunsadogam(分司都監) with the support of King Gojong and the Choi military regime, it is highly likely that 『Namyang Seonsaeng Sijib』 was produced in the same time.
Jin-Yi Han,Xu Zi Guang,Jyung-Sik Kwak,Ki-Wan Oh,Han-Ik Bae 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1
The anti-inflammatory effect of PHBV/Collagen (PHCP) was examined in a mouse model of lipopolysaccharide (LPS)-induced skin inflammation. Vascular permeability on the back skin was measured by the local accumulation of Evan’s blue dye after subcutaneous injection of LPS (30 µg site<sup>-1</sup> ). Dye leakage in the skin showed a significant increase at 2 h after injection of LPS. This LPS-induced dye leakage was also completely inhibited by HO-1 inhibitor, ZnPP, and antioxidants, including methyl gallate, trolox, and mannitol. To study the possible mechanisms underlying the in vivo anti-inflammatory effect of PHCP against LPS-induced inflammation, we also examined the effects of PHCP on malondialdehyde (MDA) and glutathione levels in skin tissues and found that pretreatment with PHCP resulted in inhibited MDA elevation and a remarkable reduction of glutathione level. In addition, similar results were obtained after pretreatment with antioxidants, including trolox and mannitol, and HO-1 inhibitor, ZnPP. Histopathologically, an influx of neutrophils into the skin dermis was detected between 24 h and 72 h after LPS injection (30, 100 µg site<sup>-1</sup>), compared to control animals after injection of saline. This increase was greater in mice treated with 100 µg of LPS than in those treated with 30 µg of LPS and was significantly suppressed by pretreatment with PHCP, antioxidants, and HO-1 inhibitor. These results collectively suggest that PHCP has an anti-inflammatory effect against LPS-induced inflammation model in vivo and may be a good candidate for the skin tissue engineering biomedical application primarily through manipulation of the redox state.
Yi, Seungjun,Kim, Jin-Hyoung,Cho, Yang-Jin,Lee, Jiwon,Choi, Tae-Sup,Cho, Dae Won,Pac, Chyongjin,Han, Won-Sik,Son, Ho-Jin,Kang, Sang Ook American Chemical Society 2016 Inorganic Chemistry Vol.55 No.7
<P>Improvement of the stability of blue phosphorescent dopant material is one of the key factors for real application of organic light-emitting diodes (OLEDs). In this study, we found that the intramolecular hydrogen bonding in an ancillary ligand from a heteroleptic Ir(III) complex can play an important role in the stability of blue phosphorescence. To rationalize the role of intramolecular hydrogen bonding, a series of Ir(III) complexes is designed and prepared: Ir(dfppy)(2)(pic-OH) (1a), Ir(dfppy)(2)-(pic-OMe) (1b), Ir(ppy)(2)(pic-OH) (2a), and Ir(ppy)(2)(pic-OMe) (2b). The emission lifetime of Ir(dfppy)(2)(pic-OH) (1a) (tau(em) = 3.19 mu s) in dichloromethane solution was found to be significantly longer than that of Ir(dfppy)(2)(pic-OMe) (1b) (tau(em) = 0.94 mu s), because of a substantial difference in the nonradiative decay rate (k(nr) = 0.28 x 10(5) s(-1) for (1a) vs 2.99 X 10(5) s(-1) for (1b)). These results were attributed to the intramolecular OH center dot center dot center dot O=C hydrogen bond of the 3-hydroxy-picolinato ligand. Finally, device lifetime was significantly improved when 1a was used as the dopant compared to FIrpic, a well-known blue dopant. Device III (1a as dopant) achieved an operational lifetime of 34.3 h for an initial luminance of 400 nits compared to that of device IV (FIrpic as dopant), a value of 20.1 h, indicating that the intramolecular hydrogen bond in ancillary ligand is playing an important role in device stability.</P>
Jin, Cho-Yi,Han, Song-Yi,Kwon, Kisang,Yun, Eun Young,Kang, Seok Woo,Goo, Tae Won,Kim, Seung-Whan,Yu, Kweon,Kwon, O-Yu Walter de Gruyter GmbH 2010 Zeitschrift fur Naturforschung. Section C Vol.65 No.1
<P>Using silkworm Bombyx mori Bm5 cells, we established a stable cell line expressing the human granulocyte macrophage colony-stimulating factor (hGM-CSF), which gets its name from the Bm5-hGM-CSF cell in which the glycoprotein of the hGM-CSF is secreted in the cell culture supernatant (CCS). It was demonstrated that secreted hGM-CSF had in vivo biological activity and the white blood cell (WBC) value increased two times that of the control. We expect to produce useful human recombinant glycoproteins from silkworm cultured cells for a low price and a large quantity</P>