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朴在贊,金武剛,金弘善,申台均 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1
This paper dealt with the histological feature of the Pekin duck olfactory mucosa and the specificity of the types of mucopolysaccharides present in the secretory cells of the duck olfactory mucosa. The nasal parts of ducks (1-week-old and 10-week-old) were fixed with 10% neutral formalin, decalcified, embedded in paraffin. Serial sections were cut 5 um thick and stained with alcian blue(pH 2.5) to demonstrate acidic mucopolysaccharides and the periodic acid-Schiff reaction to identify neutral mucopolysaccharides. The results were summarized as follows. 1. The duck olfactory mucosa consisted of the olfactory epithelia which compose of the receptor neurons, supporting cells, basal cells and goblet cells, and the lamina propria which contained Bowman's glands, olfactory nerve bunbles and connective tissue cells. 2. The thickness of the olfactory mucosa was 121.5±25.67um in the 1-week-old ducks, and 202±45.82km in the 10-week-old ducks. Increased thickness of olfactory mucosa was due to the increased thickness of lamina propria. 3. Histochemical techniques of the olfactory mucosa in 10-week-old ducks demonstrated that Goblet cells, sppporting cells and Bowman's gland contained both neutral and acidic mucopolysacc harides, the neutral mucopolysaccharides staining became enhanced first in the Goblet cells and Bowman's gland, and then in supporting cells. In 1-week-old ducks, both acidic and neutral mucopolysaccharides of Goblet cells reacted strongly, but those of supporting cells and Bowman's gland reacted presumably.
Preceding Intravenous Thrombolysis in Patients Receiving Endovascular Therapy
Park, Hong-Kyun,Chung, Jong-Won,Hong, Jeong-Ho,Jang, Min Uk,Noh, Hyun-Du,Park, Jong-Moo,Kang, Kyusik,Lee, Soo Joo,Ko, Youngchai,Kim, Jae Guk,Cha, Jae-Kwan,Kim, Dae-Hyun,Nah, Hyun-Wook,Han, Moon-Ku,Kim S KARGER AG 2017 Cerebrovascular Diseases Vol.44 No.1
<P>Background: The beneficial effects of endovascular therapy (EVT) in acute ischemic stroke have been demonstrated in recent clinical trials using new-generation thrombectomy devices. However, the comparative effectiveness and safety of preceding intravenous thrombolysis (IVT) in this population has rarely been evaluated. Methods: From a prospective multicenter stroke registry database in Korea, we identified patients with acute ischemic stroke who were treated with EVT within 8 h of onset and admitted to 14 participating centers during 2008-2013. The primary outcome was a modified Rankin Scale (mRS) score at 3 months. Major secondary outcomes were successful recanalization defined as a modified Treatment in Cerebral Ischemia score of 2b-3, functional independence (mRS score 0-2), mortality at 3 months, and symptomatic hemorrhagic transformation (SHT) during hospitalization. Multivariable logistic regression analyses using generalized linear mixed models were performed to estimate the adjusted odds ratios (ORs) of preceding IVT. Results: Of the 639 patients (male, 61%; age 69 +/- 12; National Institutes of Health Stroke Scale score of 15 [11-19]) who met the eligibility criteria, 458 received preceding IVT. These patients showed lower mRS scores (adjusted common OR, 1.38 [95% CI 0.98-1.96]). Preceding IVT was associated with successful recanalization (1.96 [1.23-3.11]) and reduced 3-month mortality (0.58 [0.35-0.97]) but not with SHT (0.96 [0.48-1.93]). Conclusion: In patients treated with EVT within 8 of acute ischemic stroke onset, preceding IVT may enhance survival and successful recanalization without additional risk of SHT, and mitigate disability at 3 months. (C) 2017 S. Karger AG, Basel</P>
Park, Sang Kyun,Cho, Min Kyoung,Park, Hye-Kyung,Lee, Keun Hee,Lee, Sun Joo,Choi, Seon Hee,Ock, Mee Sun,Jeong, Hae Jin,Lee, Moo Hyung,Yu, Hak Sun Williams Wilkins 2009 JOURNAL OF IMMUNOLOGY Vol.182 No.11
<P>We have cloned the macrophage migration inhibitory factor (MIF)-like protein (Anisakis simplex (As)-MIF) from larvae of the whale worm (Anisakis simplex third-stage larvae). Asthma was induced in the mice using OVA/alum, with or without various concentrations of rAs-MIF treatment before OVA/alum challenge. Treatment with rAs-MIF coupled with OVA/alum during the challenge period induced a complete inhibition of eosinophilia and goblet cell hyperplasia within the lung and profoundly ameliorated the development of lung hyperreactivity. Also, rAs-MIF was shown to reduce profoundly the quantity of Th2-related cytokines (IL-4, IL-5, and IL-13) in the bronchial alveolar lavage fluid and allergen-specific IgG2a in sera. IL-10 and TGF-beta levels in the bronchoalveolar lavage fluid of the rAs-MIF-treated group were significantly higher than in the other groups. Additionally, CD4(+)CD25(+)Foxp3(+) T cells (regulatory T) were recruited to the spleen and lungs of the rAs-MIF-treated mice, but this recruitment was inhibited by anti-rAs-MIF Ab.</P>
Proper Tree Vigor and Crop Load in High Density Planting System for 'Fuji'/M.9 Apple Trees
Moo-Yong Park(박무용),Jeong-Kwan Park(박정관),Sang-Jin Yang(양상진),Hyun-Hee Han(한현희),In-Kyu Kang(강인규),Jae Kyun Byun(변재균) (사)한국생물환경조절학회 2008 생물환경조절학회지 Vol.17 No.4
본 연구는 2001년부터 2003년까지 '후지'/M.9가 재식된 밀식사과원에서 적정 수세와 적정 착과량을 조사하였다. 엽과비는 평균 과중(y=1.715x+205.02, R²=0.66)과 수량(y=-35.156x+5963.7, R²=0.44)에서 고도로 유의한 상관이 있는 것으로 나타났고, 주당엽수와 평균 과중 또한 상관이 있었다. 그러나 착과량에 따른 수체생육, 과실품질 요인중 당도 및 착색도에서는 처리간 차이가 없었다. 격년결실이 발생하지 않으면서 300g 이상의 과실을 생산하는 기준은 엽과비는 55 수준에서 착과량이 주당 약 55~64개의 수준이 적합하였다. '후지'M.9 밀식재배시 성목기의 안정된 수세 기준은 평균 신초장이 20~25㎝, 신초 정지율이 95% 이상 수준을 보여야 되는 것으로 판단되며, 보다 세부적으로는 2차 생장이 거의 발생되지 않으며 과대지 비율은 적어도 20~30% 정도 되어야 할 것으로 판단되었다. Proper tree vigor and crop load were determined for 'Fuji'/M.9 apple trees in high density planting system from 2001 to 2003. Leaf/fruit ratio was highly correlated to mean fruit weight (y = l.715x+205.02, R²=0.66) and yield (y=-35.156x+5963.7, R²=0.4). In addition, there was a significant correlation between the number of leaves per tree and mean fruit weight. However, crop load did not affect tree growth, soluble solids content of fruit, and Hunter a value. To harvest the fruits heavier than 300 g without biennial bearing, it was appropriate to crop 55 to 64 fruits in a tree with 55 leaves per fruit of adult tree. The good indices for proper tree vigor could be 20 to 25 ㎝ of mean shoot length and above 95% of shoot termination rate. Moreover, no secondary growth and 20 to 30% of spur formation could be the indices for highly productive tree vigor.
심대무(Dae Moo Shim),박진영(Jin Young Park),박근호(Keun Ho Park),김태균(Tae Kyun Kim),박성규(Seong Kyu Park),양정환(Jung Hawn Yang),김종윤(Jong Yun Kim) 대한정형외과학회 2008 대한정형외과학회지 Vol.43 No.3
목적: 정형외과 영역에서 수술 현미경을 이용한 경막강내 척수외 종양에 대한 치료결과를 평가하고자 하였다. 대상 및 방법: 2001년 6월부터 2007년 5월까지 2개의 병원에서 경막강내 종양으로 절제술을 시행받은 11예를 대상으로 하였다. 평균연령은 62.4 (33-78)세로 남자 3예, 여자 8예였으며, 평균 추시기간은 18.8(1-78)개월이었다. 전 예에서 술 전 자기공명영상을 시행하여 진단하고, 수술용 현미경의 보조하에 종괴를 절제한 후 병리조직학적 소견으로 확진하였다. 임상적 평가는 시각 통증 지수 및 Cooper-Epstein 등급을 이용하여 평가하였다. 결과: 신경초종이 7예, 수막종이 4예였고, 시각통증지수는 술 전 평균 9.4에서 최종 추시상 2.4로 호전되었으며, Cooper-Epstein 등급은 술 전 평균 2.4에서 최종 추시상 0.7로 호전되었다. 결론: 수술 현미경을 이용한 경막강내 종양 절제술로 정형외과 영역에서도 양호한 결과를 얻을 수 있었다. Purpose: This article aims at evaluating the results of treatment which excise the intradural extramedullary tumor using surgical microscope, mainly concerned by the field of orthopaedic surgery. Materials and Methods: A retrospective review was carried out on 11 cases who were operated on for the excision of intradural extramedulary tumor in two hospitals from June 2001 to May 2007. Of the 11 cases, there were 3 males, and 8 females with an average age of 62.4 (33-78) years. Average follow-up period is 18.8 (1-78) months. Patients were diagnosed by MRI and pathological diagnosis was analyzed. The clinical evaluation was made by the index of VAS (visual analogue scale) and Cooper-Epstein grade. Results: 7 cases were Schwannoma and 4 cases were meningioma. The VAS take a favorable turn from average 9.4 before practice to final follow-up 2.4, and the Cooper-Epstein grade take a favorable turn from average 2.4 to final follow-up 0.7 Conclusion: A fine result of excision of the intradural extramedullary tumor with using surgical microscope could be acquired even in the field of orthopedic surgery.
연령과 성별에 따른 대장 및 직장암의 분포 변화에 대한 관찰
박창영,이희무,이만호,조용균,전우규,이상종,김병익,최윤상,김명숙,성기철,편유장 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.6
Background/Aims: Changes in subsite distribution of colorectal cancer have been shown in recent years. The carcinoma tend to shift to more proximal colon and this proximal shift is influenced by age and sex. This study was designed to delineate the relationship of age to subsite incidence of colorectal cancer and to define the role of gender in this difference. Method: We have analyzed the data by patients with colorectal cancer from 1985 to 1995 for elucidate the relationships between age, sex and prinmry location of colorectal cancer. 749 patients(male 454, female 295) were diagnosed of colorectal cancer performed by colonoscopy and/or sigmoidoeopy were divided into three groups by their location of cancer (Right colon: appendix, ascending colon, hepatic flexure, T-colon proximal 2/3 Left colon: T-colon distal 1/3, splenic flexure, descending colon, sigmoid colon Rectum: rectum). Result: 1) The mean age of all patients was 53.84±13.11 (yr). Mean ages of Right colon, Left colon, and Rectal cancer group were 55.54±14.12, 55.32±12.51, 52.22±13.09 (yr), respectively. The mean age of Right colon and Left colon cancer group is significantly older than that of Rectal cancer group (p=0.0040, p=0.0042). 2) In female age group over 56, mean age of Right colon cancer group is shown to be 3.35 and 4.82 years older than Left colon cancer group and Rectal cancer group, respectively (p=0.0062, p=0.0053) and Colon cancer tend to develop on more right side according to increase in age. 3) Above correlation was not observed below 55 of both sexes and male age group over 56. 4) No significant differences in histological differentiation and tumor stage were observed among the three groups. 5) The study was conducted to evaluate the difference in the locator of colorectal cancer between two following groups ; The first group diagnosed from 1985 to 1990 and the second group from 1991 to 199s, yet significant statistical difference was not observed. Conclusion: Age increase seems to show correlation with right shifting of colon cancer, and this correlation was most significant in old women age group. This fording suggests unknown factor strongly linked to age and sex might play important role in carcinogenesis of colorectal cancer.
소 白血病(Bovine Leukosis)에 관한 硏究 IV. 免疫擴散法과 補體結合反應法에 의한 抗體檢出 効果 比較
Moo Hyung Jun(全茂炯),Un Ik Chung(鄭雲翼),Bong Kyun Park(朴奉均),Soo Hwan An(安壽煥) 한국예방수의학회 1983 예방수의학회지 Vol.7 No.2
By using the bovine leukosis virus (BLV) antigens prepared from the culture fluid of BLV persistently infected fetal lamb kidney cells, a modification of complement fixation test was attempted to improve the specificity of the test for measurement of potency of BLV antigen, and efficiency of immunodiffusion test and the modified complement fixation test for detection of BLV antibodies in cattle sera was compared.