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민경우,이경석,박옥현,윤관주,김도술,박세일,정원삼,이대행,조영관,Min, Kyoung-Woo,Lee, Kyoung-Soek,Park, Ok-Hyun,Yoon, Kwan-Ju,Kim, Do-Sool,Park, Se-Il,Jeung, Won-Sam,Lee, Dae-Hang,Cho, Young-Gwan 한국환경보건학회 2015 한국환경보건학회지 Vol.41 No.3
Objectives: This study aimed to survey the characteristics of air quality and meteorological conditions in a greenway park. Methods: We measured meteorological and health related factors, including noise, particulate matter ($PM_{10}$) and selected gaseous air pollutants at three locations in a greenway park and on a general roadside as comparison. The measurements were repeated four times from April to October 2014. Results: The average air temperature in the greenway park was $20.7^{\circ}C$ which was $1-2^{\circ}C$ lower than on the general roadside. The average $PM_{10}$ concentration in the greenway park was $85.0{\mu}g/m^3$, a level 2-3 times lower than that at the roadside. The noise level at the greenway site was 4.4 dB(A)- 23.0 dB(A) lower than at the roadside. The average CO, $CO_2$, $SO_2$ and NOx concentrations in the greenway park were lower than at the roadside. The average phytoncide and anions concentrations in the greenway park were higher than at the roadside. Conclusions: The urban forest of the greenway park may have some impact on air quality and meteorological conditions.
다세대주택 주거지와 아파트단지 주거지에서 양육자의 일상적 이용공간에 대한 접근성 비교분석
김효정(Kim, Hyo-Jeong),반영운(Ban, Yong-Un),박경옥(Park, Kyoung-Ok) 한국주거학회 2018 한국주거학회 학술대회논문집 Vol.30 No.1
The purpose of this study is to analyze walking accessibility to multi-family houses area and apartment complexes area using space syntax and discuss it from the viewpoint of child care environment. For this study, Bokdae1-dong and Gagyeong-dong that have the most infants in Cheongju City were selected as target places. Auto Cad 2018, depthmapX_0.35_windows, and SPSS 10.0 were used for analysis. Findings of this study are as follows: 1) Apartment complexes area is wider than multi-family houses area in a range of integration level. 2) For multi-family houses area, park/playground showed the highest integration level whereas children"s hospital showed the lowest one. For apartment complexes area, children"s hospital showed the highest integration level whereas park/playground showed the lowest one. However, there was no statistically significant difference. 3) When analyzing accessibility to spaces in multi-family houses area and apartment complexes area respectively according to blocks, it was found that there was a statistically significant difference in integration level of day care center, children"s hospital, and park/playground.
Kyoung-Eun Park,Chang Youp Ok,Hye-Ock Jang,Moon-Kyoung Bae,Soo-Kyung Bae 대한구강생물학회 2020 International Journal of Oral Biology Vol.45 No.3
Resveratrol has been reported to exert anticancer activity via modulation of multiple pathways and genes. In this study, we examined the effect of resveratrol on YD-10B human oral squamous cell carcinoma cells and its molecular mechanisms of action. We found that resveratrol inhibited the proliferation of YD-10B cells in a dose- and timedependent manner. The suppressive effect of resveratrol was accompanied by a reduction in Bmi-1 gene expression. We observed that silencing the Bmi-1 gene by small interfering RNA effectively downregulated the levels of GLUT1 mRNA and protein, which were also repressed by resveratrol. Bmi-1 silencing increased the number of YD-10B cells in S-phase arrest by approximately 2.3-fold compared with the control. In conclusion, the results of the present study demonstrate, for the first time, that resveratrol suppresses Bmi-1-mediated GLUT1 expression in human oral squamous cell carcinoma cells and suggest that the specific molecular targeting of Bmi-1 and/or GLUT1 expression can be combined with a chemotherapeutic strategy to improve the response of oral cancer cells to resveratrol.
Tumorigenicity Evaluation of Umbilical Cord Blood-derived Mesenchymal Stem Cells
Park, Sang-Jin,Kim, Hyun-Jung,Kim, Woojin,Kim, Ok-Sun,Lee, Sunyeong,Han, Su-Yeon,Jeong, Eun Ju,Park, Hyun-shin,Kim, Hea-Won,Moon, Kyoung-Sik Korean Society of ToxicologyKorea Environmental Mu 2016 Toxicological Research Vol.32 No.3
Mesenchymal stem cells (MSCs) have been identified in multiple types of tissue and exhibit characteristic self-renewal and multi-lineage differentiation abilities. However, the possibility of oncogenic transformation after transplantation is concerning. In this study, we investigated the tumorigenic potential of umbilical cord blood-derived MSCs (hUCB-MSCs) relative to MRC-5 and HeLa cells (negative and positive controls, respectively) both in vitro and in vivo. To evaluate tumorigenicity in vitro, anchorage-independent growth was assessed using the soft agar colony formation assay. hUCB-MSCs and MRC-5 cells formed few colonies, while HeLa cells formed a greater number of larger colonies, indicating that hUCB-MSCs and MRC-5 cells do not have anchorage-independent proliferation potential. To detect tumorigenicity in vivo, hUCB-MSCs were implanted as a single subcutaneous injection into BALB/c-nu mice. No tumor formation was observed in mice transplanted with hUCB-MSCs or MRC-5 cells based on macro- and microscopic examinations; however, all mice transplanted with HeLa cells developed tumors that stained positive for a human gene according to immunohistochemical analysis. In conclusion, hUCB-MSCs do not exhibit tumorigenic potential based on in vitro and in vivo assays under our experimental conditions, providing further evidence of their safety for clinical applications.
Labor union associates' perception and participation on the safety and health education at work
Park, Kyoung-Ok Korean Society for Health Education and Promotion 2007 보건교육건강증진학회지 Vol.24 No.5
연구목적: 본 연구는 제조업과 건설업 사업장 노동조합관계자들의 사내 안전보건교육에 대한 인식과 참여정도를 파악하고 이들 간의 관련성을 분석하는데 그 목적을 두었다. 연구방법: 본 연구의 대상은 103명의 노동조합 관계자들(78개 제조업 산업장의 91명, 12지역의 12건설업 노동조합관계자)이었고 이들을 대상으로 자기기입식 설문조사를 실시하였다. 전국기업체산업안전협의회의 회원사들을 중심으로 우리나라 전역의 제조업과 건설업 사업장을 임의로 선정하고 선정된 사업장별로 설문지 2부, 노동부의 설문조사 협조공문, 설문조사 안내문, 설문회수용 봉투로 구성된 우편물을 사업장 노동조합사무실로 배달하는 방식으로 설문조사를 실시하였다. 80% 이상이 소속 사업장 규모가 50인 이상이었고 대부분이 결혼한 남자로 구성되어 있었다. 설문조사 내용은 대상자와 대상사업장의 일반적 특성, 사업장의 안전보건교육 특성, 노동조합의 사내 안전보건교육 참여도, 노동조합의 사내 안전 보건교육에 대한 인식으로 구성되었다. 연구결과: 전체적으로 제조업사업장에 건설업 사업장에서보다 사내 안전보건교육에 대한 인적, 물적 인프라가 잘 구축되어 있었고 사업주의 사내 안전보건교육에 대한 지원도가 높았으며, 사내 안전보건교육 담당자들의 교육역량에 대한 인식도가 더 높은 경향을 보였다. 이러한 인적, 물적 인프라는 사업장내 노동조합의 안전보건교육 참여도와 정의 상관관계가 있었으며 그 정도는 중등도 이상의 수준이었다. 결론: 이상의 결과를 토대로 볼 때, 사업장 안전보건교육에 대한 노동조합의 참여와 지지를 확충하기 위해서는 사업장 조직적으로 안전보건교육 실시에 대한 지원이 선행되어야 함을 알 수 있었다. 아울러 안전보건관리자들을 대상으로 근로자 산업재해에 대한 지식뿐만 아니라 사내 안전보건교육을 수행관리할 수 있는 '교육역량'을 기를 수 있도록 연수프로그램을 확충할 필요가 있겠다. Objectives: This study identified the labor union associates' perception and participation status on SHEW and analyzed these two Constructs correlations with Safety and health education at work(SHEW) in manufacture and construction industries. Methods: Self-administered survey was successfully finished by 103 labor union associates (91 employed in 78 manufacturing companies and 12 employed in 12 constructing companies over 12 areas). Two questionnaires, survey direction slip, the official letter to ask survey participation from Korea Ministry of Labor, and a posted envelop to return were delivered to each workplace labor union office in conveniently selected companies. Most participants' companies were at least medium to large in manufacturing industry and most associates were men and married. A survey questionnaire examined demographic characteristics, SHEW status (participation status included), and perceptions of SHEW. Results: Overall, manufacturing companies had better infrastructures for SHEW, employer support for SHEW, and current educators' competencies than constructing companies. These infrastructures for SHEW were closely correlated with company labor union participation on SHEW and the correlation coefficients were greater than any other expectations or needs variables for SHEW. Conclusions: The primary strategies for better participation and support from labor union need to be developed in supporting for organizational infrastructures related to SHEW and strengthening safety and health education training programs for supervisors or educators at work.
PARK, JI-WON,KWON, OK-KYOUNG,KIM, JUNG-HEE,OH, SEI-RYANG,KIM, JAE-HONG,PAIK, JIN-HYUB,MARWOTO, BAMBANG,WIDJHATI, RIFATUL,JUNIARTI, FIFIT,IRAWAN, DODDY,AHN, KYUNG-SEOP Spandidos Publications 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.35 No.4
<P>Rhododendron album Blume (RA) has traditionally been used as an herbal medicine and is considered to have anti-inflammatory properties. In the present study, we screened RA extracts with anti-inflammatory properties. The biological effects of an RA methanol extract (RAME) on inflammation were investigated in lipopolysaccharide (LPS)-stimulated mouse RAW264.7 cells. We investigated the effects of RAME on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated RAW264.7 cells. To explore the anti-inflammatory mechanisms of RAME, we measured the mRNA and protein expression of pro-inflammatory mediators induced by RAME in the LPS-stimulated RAW264.7 cells by RT-PCR and western blot analysis, respectively. RAME significantly inhibited the production of NO, PGE2, interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α in the LPS-stimulated RAW264.7 cells. It also suppressed the mRNA and protein expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and mitogen-activated protein kinases (MAPKs) with a concomitant decrease in the nuclear translocation of nuclear factor-κB (NF-κB) in the LPS-stimulated RAW264.7 cells. These results indicate that RAME inhibits LPS-induced inflammatory responses. These effects were considered to be strongly associated with the suppression of NF-κB activation. We therefore suggest that RAME may be prove to be an effective therapeutic agent for the treatment of inflammatory diseases.</P>