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Using Ontology to create 3D Animations for Training Purposes
Salvatore Parisi,Jochen Bauch,Jan Berssenbrugge,Rafael Radkowski 보안공학연구지원센터 2007 International Journal of Software Engineering and Vol.1 No.1
3D Computer-based animations are nowadays used for training purposes in a wide range of industrial applications like assembly, maintenance and operations. Their creation, also known as authoring, is usually a time consuming task, demanded to professional 3D designers, who need at first a good understanding of the involved entities and actions in order to realize the customized animations. The proposed methodology deals with the use of an ontology in order to filter and understand generic natural language training requests; once identified the proper actors and actions, they are associated to the corresponding models and movements to be performed in the virtual environment and translated in a 3D graphic format template. The result is a customized animation which can be created by a non-expert designer and then visualized by the worker through many modalities, on a desktop computer or on a PDA for example. Role of the ontology is to reduce the overall complexity of the animation authoring process by assuring the necessary comprehension of customized training requests as well as reusability and extensibility of the structure of the modeled object and of animations’ components in different domains..
Downs, Nathan,Parisi, Alfio Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.8
Measurements of anatomical UV exposure distribution were made using miniaturized polysulfone dosimeters over a four year period between 2005 and 2008 in Toowoomba, Australia ($28^{\circ}$ S, $152^{\circ}$ E). Anatomical UV exposures were expressed relative to the horizontal plane ambient UV. The UV exposures were compared with existing data detailing the anatomical distribution of basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and solar keratoses (SK). Surface UV exposures to unprotected skin surfaces have been presented for each of the face, neck, arm, hand and leg assessing a total of 1453 body sites (2491 measurements). Measured exposures are presented for the human facial region to a resolution of 5 mm. The median anatomical UV expressed relative to the horizontal plane ambient UV for each of the face, neck, forearm, hand and leg regions of the body varied from 26%, 23%, 13%, 30% and 12% respectively in the $0^{\circ}-30^{\circ}$ SZA range; 39%, 36%, 17%, 35% and 23% in the $30^{\circ}-50^{\circ}$ SZA range; and 48%, 59%, 41%, 42% and 47% in the $50^{\circ}-80^{\circ}$. SZA range. Detailed positions of UV exposure measured over the face, neck, arm, hand and leg were more closely related to NMSC incidence data for the face and upper limbs. Further analysis with existing facial BCC and SK density data did not however show a direct relationship with the measured UV exposures highlighting the importance of other factors influencing the causation and localisation of facial NMSC.
Measuring the influence of UV reflection from vertical metal surfaces on humans
Turner, Joanna,Parisi, Alfio V. Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.1
Erythemal UV exposure for individuals involved in outside activities are affected according to surrounding structures in an urban environment. Occupational UV exposure is likely to increase by the effects of surrounding structures. UV reflections from surrounding structures, in this case vertical metal walls, were investigated for their influence on erythemal UV exposure in the southern hemisphere. Multiple dosimeters were placed at specific features on head forms, for three different vertical wall conditions, measured at hourly intervals, providing a more detailed representation of the effect of nearby (north facing) reflective wall, non-reflective wall and no wall on UV exposure for a construction worker facing the wall direction. Two types of metal sheeting walls were investigated, with the first type (shiny and smooth in appearance) showing results that indicate the UV reflectance from this surface can increase the average erythemal UV exposure by at least 20% and up to an average of 50% for certain facial positions, compared to no wall and up to 300% compared to a non-reflective wall. A second metal sheeting type coated with colour, does not show as much influence on UV exposure for larger solar zenith angles compared to the first type of metal sheeting, but for smaller solar zenith angles provides an influence that approaches similar erythemal UV exposure to that when no wall is present. The time to reach the exposure limits defined by regulatory bodies for occupational UV exposure can be decreased if the first type of metal sheeting is in proximity to an outdoor worker. The experimental method of this study leads to discussion of how metal surfaces used in the construction industry physically reflect UV radiation. The conclusion is that albedo, which is traditionally used to measure UV reflection, is not an appropriate quantity to explore UV reflection from vertical metal surfaces. This may be due to the reason that metal surfaces seem to involve specular reflection as well as diffuse reflection.
Pamela Ferrari,Mariana Migliorini Parisi,Rafael Colombo,Matheus Becker,Gabriel Fries,Bruna Maria Ascoli,Luiza Paul Géa,Márcia Kauer-Sant’anna,Flávio Kapczinski,Fábio Klamt,Fátima T.C.R. Guma,Adriane R 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.1
Objective: Evidence has suggested that immune imbalance is involved with bipolar disorder (BD); however, its precise mechanism is poorly understood. This study investigated whether biochemical changes in the serum from BD patients could modulate the phenotype of cultured macrophages. Methods: Eighteen subjects with BD and five healthy individuals were included in this study. The human monocyte cell line U-937 was activated with phorbol 12-myristate 13-acetate (PMA) and polarization was induced with RPMI-1640 media supplemented with 10% serum from each patient for 24 hours. Gene expression of selected M1 and M2 markers was assessed by quantitative PCR. Results: Macrophages exposed to serum of manic and depressive BD patients displayed an increase of interleukin-1 (6.40±3.47 and 9.04±5.84 vs. 0.23±0.11; p<0.05) and tumor necrosis factor- (2.23±0.91 and 2.03±0.45 vs. 0.62±0.24; p=0.002 and p=0.004, respectively) compared to euthymic group (there was no difference between euthymic and controls). In parallel, U-937 macrophages treated with serum of patients in acute episode displayed a down-regulation of CXCL9 (0.29±0.20 vs. 1.86±1.61; p=0.006) and CXCL10 expression (0.36±0.15 and 0.86±0.24 vs. 1.83±0.88; p<0.000 and p=0.04) compared to the euthymia group. Conclusion: Our results are consistent with previous studies showing that changes in peripheral blood markers could modulate M1/M2 polarization in BD. The evidence of macrophages as source of inflammatory cytokines might be helpful to unravel how the mononuclear phagocyte system is involved in the etiology of BD.
Participation of Potential Transient Receptors in the Antinociceptive Effect of Pharmacopuncture
Argôlo Isabella de Paula Ribeiro,Parisi Julia Risso,Silva Josie Resende Torres da,Silva Marcelo Lourenço da 사단법인약침학회 2022 Journal of Acupuncture & Meridian Studies Vol.15 No.2
Background: Despite the widespread clinical use of acupuncture in painful situations, the use of this treatment should be further clarified. Nociception is mediated by the activation of nociceptors, such as transient receptor potentials (TRPs). The family of TRPs includes TRPV1, TRPM8, and TRPA1, which can be stimulated by substances such as capsaicin, menthol, and methyl salicylate, respectively. Objectives: This study aimed to investigate the role of TRPs in antinociception via the administration of agonists of these receptors in the Zusanli acupoint (ST36) in models of inflammatory, acute, and neuropathic pain. Methods: Male Wistar rats were used for this experiment. All rats received a subcutaneous injection of TRP agonists (capsaicin, menthol, or methyl salicylate) in ST36; saline was injected as control. Nociception was evaluated using the electronic mechanical threshold test and tail-flick test before the administration of complete Freund’s adjunct or chronic constriction injury of the sciatic nerve and after the administration of TRP agonists. Results: Nociception was found to be attenuated after treatment with TRP agonists. The administration of different doses (0.03, 0.3, and 3.0 µg/20 µL) of capsaicin, menthol, and methyl salicylate in the different pain models (neuropathic, inflammatory, and nociceptive) induced antinociception in most of the evaluated time points. Conclusion: Based on the findings, we suggest that the activation of TRPV1, TRPM8, and TRPA1 receptors results in the antinociceptive effect of the stimulation of the ST36 acupoint. Thus, TRP receptors may present a new therapeutic opportunity for the control of inflammatory and neuropathic pain.
Viviana Manzulli,Antonio Fasanella,Antonio Parisi,Luigina Serrecchia,Adelia Donatiello,Valeria Rondinone,Marta Caruso,Sabine Zange,Alina Tscherne,Nicola Decaro,Carmine Pedarra,Domenico Galante 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.1
Anthrax, caused by Bacillus anthracis, is a non-contagious infectious disease that affects a wide range of animal species (primarily ruminants) including humans. Due to the often-fatal outcome in humans, quick administration of definitely effective antimicrobials is crucial either as prophylaxis or as a clinical case therapy. In this study, 110 B. anthracis strains, temporally, geographically, and genetically different, isolated during anthrax outbreaks in Italy from 1984 to 2017, were screened using a broth microdilution method to determine their susceptibility to 16 clinically relevant antimicrobial agents. The strains were isolated from various matrices (human, animal, and environmental samples) and were representative of thirty distinct genotypes previously identified by 15-loci multiple-locus variable-number of tandem repeats analysis. The antimicrobials tested were gentamicin, ceftriaxone, streptomycin, penicillin G, clindamycin, chloramphenicol, vancomycin, linezolid, cefotaxime, tetracycline, erythromycin, rifampin, amoxicillin, ciprofloxacin, doxycycline, and trimethoprim. All isolates were susceptible to most of the tested antimicrobials, with the exception of trimethoprim for which all of them showed high minimal inhibitory concentration values. An intermediate level of susceptibility was recorded for ceftriaxone and cefotaxime. Although the Centers for Disease Control and Prevention recommend the use of doxycycline, ciprofloxacin, penicillin G, and amoxicillin for treatment of human cases and for post-exposure prophylaxis to anthrax spores, this study shows a high degree of in vitro susceptibility of B. anthracis to many other antimicrobials, suggesting the possibility of an alternative choice for prophylaxis and therapy.
Takanen, Silvia,Bangrazi, Caterina,Graziano, Vanessa,Parisi, Alessandro,Resuli, Blerina,Simione, Luca,Caiazzo, Rossella,Raffetto, Nicola,Tombolini, Vincenzo Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18
Currently the most important prognostic factor in lung cancer is the stage. In the current lung TNM classification system, N category is defined exclusively by anatomic nodal location though, in other type of tumours, number of lymph nodes is confirmed to be a fundamental prognostic factor. Therefore we evaluated the number of mediastinal lymph nodes as a prognostic factor in locally advanced NSCLC after multimodality treatment, observing a significant effect of the number of lymph nodes in terms of OS (p<0.01) and DFS (p<0.001): patients with a low number of positive mediastinal nodes have a better prognosis.