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Acellular Scaffolds as Innovative Biomaterial Platforms for the Management of Diabetic Wounds
Tallapaneni Vyshnavi,Kalaivani C.,Pamu Divya,Mude Lavanya,Singh Sachin Kumar,Karri Veera Venkata Satyanarayana Reddy 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.5
Diabetic wound (DW) is one of the leading complications of patients having a long history of uncontrolled diabetes. Moreover, it also imposes an economic burden on people suffering from wounds to manage the treatment. The major impending factors in the treatment of DW are infection, prolonged inflammation and decreased oxygen levels. Since these non-healing wounds are associated with an extended recovery period, the existing therapies provide treatment for a limited period only. The areas covered in this review are general sequential events of wound healing along with DW's pathophysiology, the origin of DW and success, as well as limitations of existing therapies. This systematic review's significant aspect is to highlight the fabrication, characterization and applications of various acellular scaffolds used to heal DW. In addition to that, cellular scaffolds are also described to a limited extent.