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Microencapsulation of Antibiotic Rifampicin in Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
N.Duran,M.A. Alvarenga,E.C. Da Silva,P.S. Melo,P.D. Marcato 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
The aim of this study was the preparation of microparticles containing rifampicin using a biodegradable polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) for oral administration produced by a bacteria. The poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microparticles with and without rifampicin were prepared by the emulsification and solvent evaporation method, in which chloroform and polyvinyl alcohol are used as the solvent and emulsifier, respectively. Microparticles were obtained within a size range of 20-60 μm by changing the initial poly(3-hydroxybutyrate-co-3-hydroxyvalerate), polyvinyl alcohol and rifampicin concentrations. An encapsulation efficiency value of 14% was obtained. The optimized total yield of 60% of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/ rifampicin was obtained. A load of 0.035 mg/1 mg of PHBV was reached. Almost 90% of the drug loaded in the microparticles was released after 24 h. The size, encapsulation efficiency and ribampicin release of the microparticles varied as a function of the initial poly(3-hydroxybutyrate-co-3-hydroxyvalerate), polyvinyl alcohol and rifampicin concentrations. It was demonstrated that the microencapsulated rifampicin, although was not totally available in the medium, exhibited a similar inhibition value as free rifampicin at 24 h of incubation with S. aureus. Cytotoxicity assays demonstrated a reduction of the toxicity when rifampicin was microencapsulated in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) while maintaining its antibacterial activity.
Microencapsulation of Antibiotic Rifampicin in Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
Duran, N.,Alvarenga, M.A.,Da Silva, E.C.,Melo, P.S.,Marcato, P.D. 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
The aim of this study was the preparation of microparticles containing rifampicin using a biodegradable polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) for oral administration produced by a bacteria. The poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microparticles with and without rifampicin were prepared by the emulsification and solvent evaporation method, in which chloroform and polyvinyl alcohol are used as the solvent and emulsifier, respectively. Microparticles were obtained within a size range of $20-60{\mu}m$ by changing the initial poly(3-hydroxybutyrate-co-3-hydroxyvalerate), polyvinyl alcohol and rifampicin concentrations. An encapsulation efficiency value of 14% was obtained. The optimized total yield of 60% of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/ rifampicin was obtained. A load of 0.035 mg/1mg of PHBV was reached. Almost 90% of the drug loaded in the micro-particles was released after 24 h. The size, encapsulation efficiency and ribampicin release of the micro-particles varied as a function of the initial poly(3-hydroxybutyrate-co-3-hydroxyvalerate), polyvinyl alcohol and rifampicin concentrations. It was demonstrated that the microencapsulated rifampicin, although was not totally available in the medium, exhibited a similar inhibition value as free rifampicin at 24 h of incubation with S. aureus. Cytotoxicity assays demonstrated a reduction of the toxicity when rifampicin was microencapsulated in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) while maintaining its antibacterial activity.
Moisés R. Cesário,Daniel A. Macedo,Rosane M. P. B. Oliveira,Patrícia M. Pimentel,Roberto L. Moreira,Dulce M. A. Melo 한양대학교 세라믹연구소 2011 Journal of Ceramic Processing Research Vol.12 No.1
Strontium-doped lanthanum manganite (La1−xSrxMnO3) is a commonly used cathode in solid oxide fuel cells. In this study,La0.80Sr0.20MnO3 powder was prepared by the modified Pechini’s method using gelatin as the polymerizing agent. The polymeric resin obtained was characterized by thermogravimetric analysis and the powder calcined at 900 oC for 4 h has been characterized by X-ray diffraction, scanning electron microscopy and infrared spectroscopy. The La0.80Sr0.20MnO3 phase exhibited rhombohedral symmetry. The infrared reflectance spectrum was dominated by a conduction mechanism besides the signature of less pronounced phonon features, characteristics of the crystal lattice. The present results indicated that the gelatin has been an efficient directional element to be used in La0.80Sr0.20MnO3 synthesis, and it is a low cost material, non toxic and makes the polymeric precursor synthesis less complicated.
Francilene V. Silva,Irisdalva S. Oliveira,Kayo A. Figueiredo,Francisco B. Melo Junior,Danielly A. Costa,Mariana H. Chaves,Mauricio P.M. Amaral,Fernanda R.C. Almeida,Francisco A. Oliveira,Rita C.M. Oli 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.6
The present work reports the anti-inflammatory and antinociceptive activities of the ethanol extract obtained from the stem bark of Sterculia striata A. St.-Hil. & Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate. The Ss-EtOH (50 mg/kg) promoted a marked inhibition on the hind paw edema induced by carrageenan or dextran (30% and 73%, respectively). Besides, Ss-EtOH (25 mg/kg) exhibited a slight activity (30%) on the hind paw edema induced by histamin. The Ss-EtOH (12.5 and 25 mg/kg) showed the antinociceptive activity on chemical stimuli induced by acetic acid (65.59% and 38.37%, respectively), formalin, in the initial (35.08% and 31.5%, respectively) and late phases (44.09% and 83.57%, respectively), capsaicin (43.77% and 51.31%, respectively), or glutamate (36.6% and 52.12%, respectively). Regarding the possible mechanism involved in the antinociceptive effect, Ss-EtOH (12.5 mg/kg) showed a decrease in the antinociceptive effect (65.8%) in the acetic acid model after pretreatment with naloxone. Thus, opioid mechanisms might be underlying this response.
Proliferative Effect of Food Plant Species from Brazil's Cerrado on Cultured Fibroblasts
Fernanda L B Mügge,Sarah M.S. Prates,Aretha P.S. Andrade,Jean C. Melo,Aristóbolo M Silva,Raquel L. Bello de Araujo,Renata A. Labanca,Maria G. L. Brandão 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.12
Brazilian Cerrado is the second largest biome in South America and contains many unstudied valuable plant species rich in bioactive substances. In this study we investigated the phenolic content and proliferative effects on cultured fibroblasts of 32 extracts of different polarities prepared from 11 plants found in Cerrado regions. Eight extracts from six species increased cell proliferation and significantly induced ATP production by the cells. Four of these extracts were obtained from plants used as food, specifically from its fruits or seeds. A high phenolic content for these eight extracts, which directly correlated with the induction of cell proliferation, was corroborated by mass spectrometry analysis. We suggest that the bioactive substance content of these species shows an interesting potential use in cosmetic and food industry, which can contribute to the conservation and sustainable development of this region.
Potential for colonization of O111:H25 atypical enteropathogenic E. coli
Marta O. Domingos,Keyde C.M. Melo,Irys Viana Neves,Cristiane M. Mota,Rita C. Ruiz,Bruna S. Melo,Raphael C. Lima,Denise S.P.Q. Horton,Monamaris M. Borges,Marcia R. Franzolin 한국미생물학회 2016 The journal of microbiology Vol.54 No.11
Using clonal phylogenetic methods, it has been demonstrated that O111:H25 atypical enteropathogenic E. coli (aEPEC) strains belong to distinct clones, suggesting the possibility that their ability to interact with different hosts and abiotic surfaces can vary from one clone to another. Accordingly, the ability of O111:H25 aEPEC strains derived from human, cat and dogs to adhere to epithelial cells has been investigated, along with their ability to interact with macrophages and to form biofilms on polystyrene, a polymer used to make biomedical devices. The results demonstrated that all the strains analyzed were able to adhere to, and to form pedestals on, epithelial cells, mechanisms used by E. coli to become strongly attached to the host. The strains also show a Localized-Adherence- Like (LAL) pattern of adhesion on HEp-2 cells, a behavior associated with acute infantile diarrhea. In addition, the O111:H25 aEPEC strains derived either from human or domestic animals were able to form long filaments, a phenomenon used by some bacteria to avoid phagocytosis. O111:H25 aEPEC strains were also encountered inside vacuoles, a characteristic described for several bacterial strains as a way of protecting themselves against the environment. They were also able to induce TNF-α release via two routes, one dependent on TLR-4 and the other dependent on binding of Type I fimbriae. These O111:H25 strains were also able to form biofilms on polystyrene. In summary the results suggest that, regardless of their source (i.e. linked to human origin or otherwise), O111:H25 aEPEC strains carry the potential to cause human disease.
A ´ngel L. A ´ lvarez,Santiago Melo´n,Kevin P. Dalton,Ine´s Nicieza,Annele Roque,Bele´n Sua´rez,Francisco Parra 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.6
The anti–herpes simplex virus type 1 and anti–herpes simplex virus type 2 effects of apple pomace, a byproduct from the cider-processing industry, were investigated. The mechanisms of antiviral action were assessed using a battery of experiments targeting sequential steps in the viral replication cycle. The anti-herpetic mechanisms of apple pomaces included the inhibition of virus attachment to the cell surface and the arrest of virus entry and uncoating. Quercitrin and procyanidin B2 were found to play a crucial role in the antiviral activity.
Shannon, A.,Sotirova, E.,Atanassov, K.,Krawczak, M.,Melo-Pinto, P.,Kim, T.,Jang, L.C.,Kang, Dong-Jin,Rim, S.H. Korean Institute of Intelligent Systems 2006 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.6 No.1
A generalized net is used to construct a model which describes the process of evaluation of the problems solved by students. The model utilizes the theory of intuitionistic fuzzy sets. The model can be used to simulate some processes, related to estimation of students' background.
TOWARDS A MODEL OF THE DIGITAL UNIVERSITY : A GENERALIZED NET MODEL FOR PRODUCING COURSE TIMETABLES
A. Shannon,D. Orozova,E. Sotirova,K. Atanassov,M. Krawczak,P. Melo-Pinto,R. Nikolov,S. Sotirov,T. Kim(김태균) 한국지능시스템학회 2008 한국지능시스템학회 학술발표 논문집 Vol.18 No.1
In a series of research papers, the authors have studied some of the most important models of a contemporary universities, such as: the research university, the entrepreneurial university and the digital university and construct their Generalized Net (GN) models. This paper is based on the case-studies of Sofia University, the Technical University of Munich and the University of Edinburgh. The main focus is to put the analysis of the processes of the functioning of a university which effectively integrates Information and Communication Technologies (ICT) in all university activities. A concrete example based on the process of course administration at University of Edinburgh is considered. This university is in a process of developing an integrated information system covering most of the university activities. The opportunity of using GNs as a tool for modeling such processes is analyzed as well.