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Venugopal P. Menon,Kode Aruna,Penumathsa Suresh Varma,Kallikat Narayanan Rajasekaran,Rajagopalan Rukkumani 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.2
Excessive alcohol intake induces hyperlipidemia. Studies suggest that natural principles and their analogs are known to possess anti-hyperlipidemic properties. In the present work we tested the effect of curcumin, an active principle of turmeric (Curcuma longa), and a curcumin analog on alcohol- and thermally oxidized polyunsaturated fatty acid (PUFA)- induced hyperlipidemia. Male albino Wistar rats were used for the experimental study. Anti-hyperlipidemic activity of curcumin and curcumin analog was evaluated by analyzing the levels of cholesterol, triglycerides (TGs), phospholipids (PLs), and free fatty acids (FFAs). The results showed that the levels of cholesterol, TGs, PLs, and FFAs were increased significantly in alcohol-, PUFA-, and alcohol PUFA-treated groups, which were brought down significantly on treatment with either of the curcuminoids. Curcumin analog treatment was found to be more effective than curcumin treatment. From the results obtained, we conclude that both curcumin and its analog effectively protect the system against alcohol- and PUFA-induced hyperlipidemia and are possible candidates for the treatment of hyperlipidemia.
Venugopal P. Menon,Rajagopalan Rukkumani,Penumathsa Suresh Varma,Kode Aruna 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.2
The matrix metalloproteinases (MMPs) are a family of secreted and membrane-bound zinc endopeptidases.Collectively, these enzymes can degrade all of the components of the extracellular matrix including collagen, fibronectin,laminin, and basement membrane glycoproteins. Regulation in expression and activation of proteinases is one of the most im-portant mechanisms in organ morphogenesis. Fibrosis is a dynamic pathological process with a net accumulation of extra-cellular matrix proteins. In the present communication, we have investigated the changes that occur in the activity of liverMMPs in normal and in pathological conditions. The activity of MMPs was increased in thermally oxidized sunflower oil-and alcohol-treated groups, whereas the activity was decreased in the thermally oxidized oil. alcohol-fed group when com-pared with the normal control group. The activity was positively modulated when dendrodoine analogue [4-amino-5-benzoyl-2(4-methoxyphenylamino)thiazole] was administered along with ethanol and thermally oxidized oil, which indicates the pro-tective effect of this drug.
Dynamic Session Key based Pairwise Key Management Scheme for Wireless Sensor Networks
( Premamayudu B ),( K. Venkata Rao ),( P. Suresh Varma ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.12
Security is one of the major challenges in the Wireless Sensor Networks (WSNs). WSNs are more vulnerable to adversarial activities. All cryptographic security services indirectly depend on key management. Symmetric key management is the best key establishment process for WSNs due to the resource constraints of the sensors. In this paper, we proposed dynamic session key establishment scheme based on randomly generated nonce value and sensor node identity, in which each sensor node is equipped with session key on expire basis. The proposed scheme is compare with five popular existing key management systems. Our scheme is simulated in OMNET++ with MixiM and presented experimental results. The analytical study and experimental results show the superiority of the proposed scheme over the existing schemes in terms of energy, storage, resilience and communication overhead.
Prediction Based Cost Estimation Model Using Clusters
Subba Rao Peram,Dr. K. Venkata Rao,Dr. P. Suresh Varma 보안공학연구지원센터 2015 International Journal of Software Engineering and Vol.9 No.7
On some parameters Software cost estimation based on development and effort on the project. Every line of code and every method are important to estimate the cost of project. To develop the software project using well defined scientific principles, methods, statements and functions, though there are many costs estimation models are available to estimate the cost of project, but still there is lack of efficient system to predict the cost estimation based on size of project, functionality of project, methods of project. In the existing system cost estimation is done on the basis of lines of code, resource management, in time process. Because of various reasons in the existing system we have identified the drawbacks. In this paper, cost prediction model is defined based on clusters, the number of clusters will form the centroids. Each centroid has a specific number of clusters. Each cluster will be called as rule. In this paper, results will show the prediction of cost estimation is defined.