Effects of a fentanyl-propofol mixture on propofol injection pain: a randomized clinical trial

Nurcan Kizilcik,Ferdi Menda,Sevgi Bilgen,Ozgül Keskin,Ozge Koner 대한마취통증의학회 2015 Korean Journal of Anesthesiology Vol.68 No.6

Background: Propofol injection pain is a common problem that can be very distressing for patients. We compared the effects of injection with saline followed by injection with a fentanyl-propofol mixture, injection with fentanyl followed by a propofol injection, and injection with saline followed by propofol alone on propofol injection pain. Methods: The patients were assigned randomly to one of three groups. A rubber tourniquet was placed on the forearm to produce venous occlusion for 1 min. Before anesthesia induction, group C (control, n = 50) and group M (fentanylpropofol mixture, n = 50) received 5 ml of isotonic saline, while group F (fentanyl, n = 50) received 2 μg/kg of fentanyl. After the tourniquet was released, groups C and F received 5 ml of propofol and group M received 5 ml of a mixture containing 20 ml of propofol and 4 ml of fentanyl. At 10 s after the study drugs were given, a standard question about the comfort of the injection was asked of the patient. We used a verbal rating scale to evaluate propofol injection pain. Statistical analyses were performed with Student’s t-tests and Fisher’s exact tests; P < 0.05 was considered to indicate statistical significance. Results: The demographic data were similar among the groups. In group M, the number of patients reporting propofol injection pain was significantly lower than in groups F and C (both P < 0.001). No patient in group F or M experienced severe pain, whereas 24 patients (48%) had severe pain in group C (both P < 0.001). Conclusions: This study shows that a fentanyl-propofol mixture was more effective than fentanyl pretreatment or a placebo in preventing propofol injection pain.

Low magnitude high frequency vibrations expedite the osteogenesis of bone marrow stem cells on paper based 3D scaffolds

Ozge Karadas,Gulistan Mese,Engin Ozcivici 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.3

Anabolic eff ects of low magnitude high frequency (LMHF) vibrations on bone tissue were consistently shown in the literaturein vivo, however in vitro eff orts to elucidate underlying mechanisms are generally limited to 2D cell culture studies. Threedimensional cell culture platforms better mimic the natural microenvironment and biological processes usually diff er in 3Dcompared to 2D culture. In this study, we used laboratory grade fi lter paper as a scaff old material for studying the eff ects ofLHMF vibrations on osteogenesis of bone marrow mesenchymal stem cells in a 3D system. LMHF vibrations were applied15 min/day at 0.1 g acceleration and 90 Hz frequency for 21 days to residing cells under quiescent and osteogenic conditions. mRNA expression analysis was performed for alkaline phosphatase (ALP) and osteocalcin (OCN) genes, Alizarinred S staining was performed for mineral nodule formation and infrared spectroscopy was performed for determination ofextracellular matrix composition. The highest osteocalcin expression, mineral nodule formation and the phosphate bandsarising from the inorganic phase was observed for the cells incubated in osteogenic induction medium with vibration. Ourresults showed that fi lter paper can be used as a model scaff old system for studying the eff ects of mechanical loads on cells,and LMHF vibrations induced the osteogenic diff erentiation of stem cells.

Pharyngeal airway dimensions in skeletal class II: A cephalometric growth study

Ozge Uslu-Akcam 대한영상치의학회 2017 Imaging Science in Dentistry Vol.47 No.1

Purpose: This retrospective study aimed to evaluate the nasopharyngeal and oropharyngeal dimensions of individuals with skeletal class II, division 1 and division 2 patterns during the pre-peak, peak, and post-peak growth periods for comparison with a skeletal class I control group. Materials and Methods: Totally 124 lateral cephalograms (47 for skeletal class I; 45 for skeletal class II, division 1; and 32 for skeletal class II, division 2) in pre-peak, peak, and post-peak growth periods were selected from the department archives. Thirteen landmarks, 4 angular and 4 linear measurements, and 4 proportional calculations were obtained. The ANOVA and Duncan test were applied to compare the differences among the study groups during the growth periods. Results: Statistically significant differences were found between the skeletal class II, division 2 group and other groups for the gonion-gnathion/sella-nasion angle. The sella-nasion-B-point angle was different among the groups, while the A-point-nasion-B-point angle was significantly different for all 3 groups. The nasopharyngeal airway space showed a statistically significant difference among the groups throughout the growth periods. The interaction among the growth periods and study groups was statistically significant regarding the upper oropharyngeal airway space measurement. The lower oropharyngeal airway space measurement showed a statistically significant difference among the groups, with the smallest dimension observed in the skeletal class II, division 2 group. Conclusion: The naso-oropharyngeal airway dimensions showed a statistically significant difference among the class II, division 1; class II, division 2; and class I groups during different growth periods.

Letters to the Editor : Prayer Mark on the Forehead: Hyperpigmentation

( Ozge Mine Orenay ),( Evren Sarifakioglu ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.1

Experimental setup for testing climatic stress component in vegetation via AM: challenges and new opportunities

Ozge Ogut,Ole Emil Herrmann,Chao Gao,Nerantzia Julia Tzortzi,Chiara Bertolin 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.11

This study aims to analyze the challenges and the opportunities in developing an experimental setup to test climatic stress on vegetation using additive manufacturing (AM). Vegetation is unavoidable to analyze as species are the components of vertical green structures (VGS). These structures can increase the amount of green infrastructure in built environments optimizing space-related concerns. One benefit of VGS is to act as a thermal insulator by changing microclimate. It helps to stabilize temperature, and to reduce energy needs’ amount. To optimize these benefits, the vegetation selection must be done in an efficient way and each plant’s reaction to hygro-thermal variations should be evaluated quantitatively. AM offers opportunity to create reference object to study the effect of hygro-thermal modifications on leaves. In fact, AM-leaves used as reference shapes in comparison with real leaves’ shapes are not modifiable in the range of the experimental climate conditions and may help in detecting anomalies. The experimental procedure has still to be created and tested. This paper underlines the challenges met while developing such preliminary experimental setup and the initial tests which have offered solutions to the technical barriers.

Predictive Value of the TRACK Questionnaire as a Measure of Asthma Control in Preschool Aged Children

Ozge Yilmaz,Ahmet Turkeli,Sebnem Sahin,Hasan Yuksel 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.4

Assessment of asthma control in preschool children is important for therapeutic decisions. Aim of this study was to evaluate the predictive value ofTRACK questionnaire scores for subsequent clinical parameters and to investigate the validity and reliability of the Turkish version of the TRACKquestionnaire. We enrolled 100 children with asthma aged 4 years or younger in this cohort study. We recorded sociodemographic characteristicsand clinical severity parameters. A pediatric allergist filled in the asthma severity scale and the caregiver of the child filled in the TRACK questionnaire. We called in the children again at the end of one month and recorded the same parameters and administered TRACK again. Uncontrolled asthmawas defined as a TRACK score below 80. According to the TRACK score, 65% of the children had controlled asthma initially while at the end ofthe study 64.1% had controlled asthma. At the beginning of the study, all clinical parameters were worse in children with uncontrolled asthma accordingto TRACK score. Similarly, other objective clinical parameters during the following one month period were worse in children with initial uncontrolledasthma. Cronbach’s alpha score for the TRACK questionnaire was 0.84. Turkish TRACK questionnaire is a valid and reliable tool that is predictiveof short term asthma prognosis.

Chilaiditi syndrome

( Ozge Karaman ),( Muzaffer Kahyaoglu ),( Emine Alpay ),( Arzu Kalaycı ),( Cetin Gecmen ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.6

Applying nano-HA in addition to scaling and root planing increases clinical attachment gain

Uysal, Ozge,Ustaoglu, Gulbahar,Behcet, Mustafa,Albayrak, Onder,Tunali, Mustafa Korean Academy of Periodontology 2021 Journal of Periodontal & Implant Science Vol.51 No.-

Purpose: This study evaluated the efficacy of treating periodontitis using subgingival nano-hydroxyapatite powder with an air abrasion device (NHAPA) combined with scaling and root planing (SRP). Methods: A total of 28 patients with stage III periodontitis (grade B) were included in this study, although 1 was lost during follow-up and 3 used antibiotics. The patients were divided into a test group and a control group. All patients first received whole-mouth SRP using hand instruments, and a split-mouth approach was used for the second treatment. In the test group, the teeth were treated with NHAPA for 15 seconds at 70% power per pocket. Subgingival plaque samples were obtained from the 2 deepest pockets at the test and control sites before treatment (baseline) and 3 months after treatment. The full-mouth plaque index (PI), gingival index (GI), papillary bleeding index (PBI), bleeding on probing (BOP), probing depth (PD) and clinical attachment level (CAL) were recorded at baseline and at 1- and 3-month post-treatment. Real-time polymerase chain reaction was used to determine the colonisation of Treponema denticola (Td), Porphyromonas gingivalis (Pg), and Aggregatibacter actinomycetemcomitans in the subgingival plaque. Results: From baseline to the first month, the test group showed significantly larger changes in BOP and CAL (43.705%±27.495% and 1.160±0.747 mm, respectively) than the control group (36.311%±27.599% and 0.947±0.635 mm, respectively). Periodontal parameters had improved in both groups at 3 months. The reductions of PI, GI, BOP, PD, and CAL in the test group at 3 months were greater and statistically significant. The total bacterial count and Td and Pg species had decreased significantly by the third month in both groups (P<0.05). Conclusions: Applying NHAPA in addition to SRP improves clinical periodontal parameters more than SRP alone. Subgingival NHAPA may encourage clot adhesion to tooth surfaces by increasing surface wettability.

Effect of cycle numbers on the structural, linear and nonlinear optical properties in Fe2O3 thin films deposited by SILAR method

Erken Ozge 한국물리학회 2022 Current Applied Physics Vol.34 No.-

Fe2O3 thin films were deposited by Successive Ionic Layer Adsorption and Reaction (SILAR) method onto glass substrates at different cycle numbers to investigate structural, linear and nonlinear optical properties. X-Ray Diffraction (XRD) analysis revealed that the Fe2O3 thin films have a non-crystalline nature. The morphological properties of the films were investigated by Field Emission-Scanning Electron Microscopy (FE-SEM) and the results show that the films’ surfaces are porous. The linear and nonlinear optical parameters were evaluated and analyzed by using transmittance and absorbance measurements. For these measurements, UV–Vis spectroscopy at room temperature was used. The refractive index values were calculated in the range of 1.45–3.23 for visible region (400–700 nm). Obtained results reveal that direct optical band gap changed between 2.62 and 2.68 eV and indirect optical band gap changed between 1.67 and 1.77 eV. Additionally, optical electronegativity, optical dielectric constants, surface and volume energy loss functions, nonlinear refractive index, linear optical susceptibility, third-order nonlinear optical susceptibility, optical and electrical conductivity, and loss tangent values were calculated and discussed in detail. It was found that each parameter studied is dependent on the cycle numbers. Also, it can be stated that Fe2O3 thin films are promising candidate for solar cells and optoelectronic device technology.

Traditional topical herbal therapies in psoriasis

Havva Ozge Keseroglu,Müzeyyen Gönül 셀메드 세포교정의약학회 2014 TANG Vol.4 No.4

Psoriasis is a common, chronic, recurrent, immune-mediated inflammatory disorder of skin. Although conventional topical and systemic therapies yield remission for a while, they carry a risk of many side effects that limit the long term use of these agents and the disease recurs generally in a short period of time after cessation of therapy. An increasing number of psoriatic patients are using herbal products as a treatment to control their disease with less side effects. Clinicians should be aware of plants used in psoriasis and side effects related with them. The aim of this article is to review the different herbs used in psoriasis treatment.