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Synthesis of Pegylated Immunonanoparticles
Oliver, Jean-Christophe,Huertas, Ramon,Lee, Hwa Jeong,Calon, Frederic,Pardridge, William M. 梨花女子大學校 藥學硏究所 2002 藥學硏究論文集 Vol.- No.11
Purpose. This work describes the syrthesis of pesylated immu-nonanoparticies by conjugation of an anti-transferrin receptor mono-clonal antibody (MAb) to maleimide-grafted pegylated nanoparticlesprepared from poly(lactic acid) (PLA) and a hi-functional polyeth-yleneglycol (PEG).Methods. Maleimide-PEG_3500-PLA_4000 and methoxy PEG_2600-PLA_4000 copolymers were synthesized by ring opening polymeriza-tion of L-lactide using stannous octoate as catalyst. Pegylated nano-particles were prepared from these copolymers by a multiple emul-sion/solvent evaporation method and thiolated OX26 MAb wasconjugated through the maleimide function located at the distal endof the PEG spacer. The pegylated immunonanoparticles were char-actenzed by quasi-elastic light scattering, gel permeation chromatog-raphy, turbidimetry assays, and transmission electron microscopy.Results. NMR spectroscopy confirmed the synthesis of both copoly-mers and the preservation of the maleimide function. The pegylatedimmunonanoparticles had an auerage diameter of 121 ± 5 nm andappeared spherical by transmission electron microscopy. The numberof OX26 MAb molecules conjugated per individual pegylated nano-particle was 67 ± 4. The MAb conjugated to the surface of the pe-gylated immunonanoparticle was visualized directly by electron mi-croscopy using a conjugate of 10 nm gold and an anti-mouse immu-noglobulin secondary antibody.Conclusion. Pegylated immunonanopartirles can be synthesized withbifunctional PEG derivatives that bridge the nanoparticle and thetargeting MAb. This novel formulation may enable the targeted de-livery of small molecules, protein drugs, and gene medicines.
Evaluation of Resolution Improvement Ability of a DSP Technique for Filter-Array-Based Spectrometers
Oliver, J.,Lee, Woong-Bi,Park, Sang-Jun,Lee, Heung-No The Korea Institute of Information and Commucation 2013 韓國通信學會論文誌 Vol.38 No.6C
In this paper, we aim to evaluate the performance of the digital signal processing (DSP) algorithm used in [8] in order to improve the resolution of spectrometers with fixed number of low-cost, non-ideal filters. In such spectrometers, the resolution is limited by the number of filters. We aim to demonstrate via new experiments that the resolution improvement by six times over the conventional limit is possible by using the DSP algorithm as claimed by [8].
Oliver Cruz-Milán,Veysel Avsar 한국마케팅과학회 2021 마케팅과학연구 Vol.31 No.4
Given some of the limitations of survey-based methodologies to assess tourism advertising and promotional programs, the objective of this research is to evaluate the effectiveness of Mexico’s tourism promotion board campaigns executed through digital media channels between 2012 and 2017 using a quasi-experimental, longitudinal design. A difference-in-difference model is estimated to compare the tourism inflow from countries before and after receiving the online promotion (treatment) with a control group of countries that did not receive it, controlling for demographic and economic variables that influence tourism inflow. The study results and return on investment estimations demonstrate that the digital advertising campaign has a significant effect on annual international visitor arrivals, underscoring the importance of employing cost-effectiveness metrics to determine the impact of marketing investments.
Oliver Muñiz-Serrato,Juan Serrato Rodríguez 한양대학교 세라믹연구소 2015 Journal of Ceramic Processing Research Vol.16 No.5
Ultra-fine crystalline anatase nano-powders of less than 6 nm particle size have been obtained at the early stage of crystallization using the one step low temperature non-aqueous sol gel-solvothermal treatment of the Ti(OBu)4 precursor. The solvothermal treatment is held at 110 o C for 10, 20, 40, 60 hours in the presence of 2-etoxiethanol and ethanol as solvent. Nanostructural development is followed by TEM, HRTEM, electron and X Ray diffraction. Particle coarsening by oriented attachment is evidenced by HRTEM observations and by particle growth kinetics during the solvothermal treatment.
두 개의 중첩 레이저 빔을 사용하여 구리 헤어핀의 레이저 용접에서 스패터와 기공의 감소
Oliver Bocksrockera,Nicolai Spekera,Matthias Beraneka,Tim Hessea 한국레이저가공학회 2020 Laser Solutions Vol.23 No.12
헤어핀 기술은 e-Mobility 자동차 부문의 파워 트레인 효율성을 높이기 위한 e-Drive 제조에 새로운 수준의 자유를 제공한다. 구리 헤어핀의 레이저 용접에 대한 실험적 조사를 통해 소위 “2in1-fiber”를 이용한 중첩된 레이저 빔(BrightLine Weld)의 특정 빔 프로파일이 키홀을 안정화시켜 결과적으로 스패터와 기공을 감소시킨다는 것을 알아냈다. 스패터 정량화를 위해 프로세스의 고속 동영상이 사용되었다. 용접 중 기공 생성은 온라인 xRay-imaging을 통해 조사되었다. 관찰에 따르면, 중첩된 레이저빔이 사용될 경우 키홀의 크기가 넓어지는 것으로 나타났다. 그 결과, 키홀의 형태가 시간이 경과함에 따라 안정화되었다. 또한 키홀 형태 덕분에 증발된 물질의 증기를 수월하게 제거할 수 있다. 후자는 키홀이 부푸는 것을 억제하며 따라서 헤어핀 용접 프로세스 중에 스패터와 기공이 형성되는 것을 0에 가깝게 줄일 수 있다.