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Ok, Seong Ho,Bae, Sung Il,Kwon, Seong Chun,Park, Jung Chul,Kim, Woo Chan,Park, Kyeong Eon,Shin, Il Woo,Lee, Heon Keun,Chung, Young Kyun,Choi, Mun Jeoung,Sohn, Ju Tae The Korean Pain Society 2014 The Korean Journal of Pain Vol.27 No.3
Background: A toxic dose of bupivacaine produces vasodilation in isolated aortas. The goal of this in vitro study was to investigate the cellular mechanism associated with bupivacaine-induced vasodilation in isolated endothelium-denuded rat aortas precontracted with phenylephrine. Methods: Isolated endothelium-denuded rat aortas were suspended for isometric tension recordings. The effects of nifedipine, verapamil, iberiotoxin, 4-aminopyridine, barium chloride, and glibenclamide on bupivacaine concentration-response curves were assessed in endothelium-denuded aortas precontracted with phenylephrine. The effect of phenylephrine and KCl used for precontraction on bupivacaine-induced concentration-response curves was assessed. The effects of verapamil on phenylephrine concentration-response curves were assessed. The effects of bupivacaine on the intracellular calcium concentration ($[Ca^{2+}]_i$) and tension in aortas precontracted with phenylephrine were measured simultaneously with the acetoxymethyl ester of a fura-2-loaded aortic strip. Results: Pretreatment with potassium channel inhibitors had no effect on bupivacaine-induced relaxation in the endothelium-denuded aortas precontracted with phenylephrine, whereas verapamil or nifedipine attenuated bupivacaine-induced relaxation. The magnitude of the bupivacaine-induced relaxation was enhanced in the 100mM KCl-induced precontracted aortas compared with the phenylephrine-induced precontracted aortas. Verapamil attenuated the phenylephrine-induced contraction. The magnitude of the bupivacaine-induced relaxation was higher than that of the bupivacaine-induced $[Ca^{2+}]_i$ decrease in the aortas precontracted with phenylephrine. Conclusions: Taken together, these results suggest that toxic-dose bupivacaine-induced vasodilation appears to be mediated by decreased calcium sensitization in endothelium-denuded aortas precontracted with phenylephrine. In addition, potassium channel inhibitors had no effect on bupivacaine-induced relaxation. Toxic-dose bupivacaine-induced vasodilation may be partially associated with the inhibitory effect of voltage-operated calcium channels.
Ok-Chul Chung,Hong-Gyu Kang,Tae-Woong Bae,Hyeon-Jin Sun,Jeong-Keun Choi,Pyung Ok Lim,Hyo-Yeon Lee 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Daily shedding pattern and longevity of pollen are important consideration for the evaluation of gene flow of transgenic plants. During the day, the pollen shedding pattern of zoysiagrass was determined in the lawn by using a device to collect airborne pollen on a glass slide, resulting that the pollen grains were released predominantly between 7:00 and 9:00. The result was also supported by in vitro pollen germination test, which was performed with pollens collected from 1:00 through 24:00 at 1h interval. Influence of temperature and humidity on pollen longevity was determined by germinating pollen at 25°C after incubating them for 10, 30, 60, and 180 min under different temperatures and humidity with pollen of zoysiagrass that opened freshly at about 9:00. The result showed that pollen longevity of zoysiagrass was sensitive to change of temperature and humidity and longest under the temperture and humidity of 15-20°C and 80-99%, respectively. Under natural conditions with the same method as upper controlled conditions, was determined pollen longevity. Under sunny atmospheric conditions, pollen longevity decreased to 20% in 60 min, with a complete extinction in 120 min. Under cloudy atmospheric conditions, pollen remained viable up to 450 min, with about 20% longevity after 360 min. No significant difference was found between GM and non-GM plants in their pollen longevity.
Chung, Seung Yeun,Chang, Jong Hee,Kim, Hye Ryun,Cho, Byoung Chul,Lee, Chang Geol,Suh, Chang-Ok The Korean Society for Radiation Oncology 2017 Radiation Oncology Journal Vol.35 No.2
Purpose: To evaluate intracranial control after surgical resection according to the adjuvant treatment received in order to assess the optimal radiotherapy (RT) dose and volume. Materials and Methods: Between 2003 and 2015, a total of 53 patients with brain oligometastases from non-small cell lung cancer (NSCLC) underwent metastasectomy. The patients were divided into three groups according to the adjuvant treatment received: whole brain radiotherapy (WBRT) ${\pm}$ boost (WBRT ${\pm}$ boost group, n = 26), local RT/Gamma Knife surgery (local RT group, n = 14), and the observation group (n = 13). The most commonly used dose schedule was WBRT (25 Gy in 10 fractions, equivalent dose in 2 Gy fractions [EQD2] 26.04 Gy) with tumor bed boost (15 Gy in 5 fractions, EQD2 16.25 Gy). Results: The WBRT ${\pm}$ boost group showed the lowest 1-year intracranial recurrence rate of 30.4%, followed by the local RT and observation groups, at 66.7%, and 76.9%, respectively (p = 0.006). In the WBRT ${\pm}$ boost group, there was no significant increase in the 1-year new site recurrence rate of patients receiving a lower dose of WBRT (EQD2) <27 Gy compared to that in patients receiving a higher WBRT dose (p = 0.553). The 1-year initial tumor site recurrence rate was lower in patients receiving tumor bed dose (EQD2) of ${\geq}42.3Gy$ compared to those receiving <42.3 Gy, although the difference was not significant (p = 0.347). Conclusions: Adding WBRT after resection of brain oligometastases from NSCLC seems to enhance intracranial control. Furthermore, combining lower-dose WBRT with a tumor bed boost may be an attractive option.
지상국 추적 데이터를 이용한 저궤도 위성의 궤도결정 특성 분석
정옥철(Ok-Chul Jung),최수진(Su-Jin Choi),정대원(Dae-Won Chung),김은규(Eun-Kyou Kim),김학정(Hak-Jung Kim) 한국항공우주연구원 2011 항공우주기술 Vol.10 No.2
본 논문에서는 지상국에서 추적한 저궤도 위성의 방위각 및 고도각을 관측자료로 이용하여 궤도결정을 수행한 결과를 분석하였다. 지상국 추적 데이터는 발사 후 초기 궤도결정을 위한 관측자료로 유용하게 사용된다. 이를 위해 지상국 추적데이터에 대한 표준 인터페이스 포맷을 정리하였고, 특정 지상국에 대한 추적 데이터의 통계적인 특성을 살펴보았다. 최소자승법을 이용한 궤도결정을 위해 연속되는 교신패스를 통해 얻은 아리랑 2호의 방위각/고도각을 축적하여 관측자료로 이용함으로써 다양한 조합에 따른 궤도결정 결과를 분석하였고, 궤도결정 성능 검증을 위해 GPS 항행해를 이용한 궤도결정 값과 비교하였다. This paper analyzes the orbit determination results using azimuth and elevation angle from ground tracking data, which has the standard data interface format, GEOS-C. The ground tracking data is very useful for initial orbit determination after a satellite launch. In this paper, the quality of the measurement data has been investigated using a variety of real tracking passes, compared with the high precision orbit data of KOMPSAT-2. The accumulated tracking data from consecutive satellite-ground passes is processed for orbit determination using least square method. The accuracy of orbit determination result is also presented.
( Jung Chul Kim ),( Sun Ok Chung ),( Byoung Kwan Cho ),( Hong Hee Chang ),( Suk Kim ),( Dong Il Chang ) 한국농업기계학회 2013 바이오시스템공학 Vol.38 No.4
Purpose: The objectives of this study were to develop an automated disinfectant dilution system, and an automated data management system for spraying amount for resolving uncertainty problem. Methods: Proper diluting rate was made by a controlled volume pump for liquid disinfectant and a screw conveyer pump for solid disinfectant. The water capacity of disinfecting system of 400 L was controlled by two water level sensors. The water quantity of water tank was controlled by the signals which were produced by the water level sensors. Signals were processed by Labview Programming, and ON/OFF of solenoid valve that was used for controlling water supplying to water tank, was controlled by SSR. The operating time of pumps for disinfectant was controlled quantitatively. A turbine flowmeter was used for development of automated measurement system for spraying amount of disinfectant. In order to save the flowmeter data and to control the spraying system, a multi-function data logger was used, and it was processed and saved in Excel file by a program developed in this study. Results: Labview 2010 was used for programming to control the automated measurement system for spraying amount of disinfectant. Results showed that the relationship between flowmeter value and time had a significant linear relationship such as 0.99 of R2. Generally, 6.74 L/s of diluted disinfectant is sprayed for a vehicle passing through the disinfection system (about 15 seconds). Test results showed that average error between the measured spraying amount and the flowmeter data was 50 mL, and the range of error was 1.3%. Since the amount and time of spraying could be saved in real-time by using the spreadsheet files which could not be modified arbitrarily, it made possible to judge objectively whether the disinfection spraying was performed or not. Test results of spraying liquid and solid disinfectant showed that the errors between the measured discharge rate and the theoretical one were ranged within 3-4% for various dilution rates. Conclusions: The disinfection system developed would be working accurately. The automated spraying data base management system satisfied the purpose of this study. The automated dilution process system developed in this study could discharge liquid and solid disinfectant with accurate dilution rate, relatively.
정옥철(Ok-Chul Jung),김해동(Hae-Dong Kim),최수진(Su-Jin Choi),정대원(Dae-Won Chung) 한국항공우주연구원 2009 항공우주기술 Vol.8 No.2
본 논문에서는 단일 임무운용 개념에서 벗어나 향후 다수의 위성들을 동시에 직접 제어하거나, 임무가 상이하더라도 주요 핵심시스템을 근간으로 각 위성마다 소요되는 임무운용 시스템을 개발함에 있어 개발기간을 획기적으로 줄일 수 있는 차세대 통합형 임무운용시스템 개발을 위한 분석 및 설계결과를 기술하였다. 이를 위해 우주개발선진국들의 통합지향형 임무운용시스템 개발 추세 및 개발 동향을 살펴보고, 각 시스템들의 주요 기능을 수행하는 공통 핵심시스템의 구조도 분석하였으며 설계 결과를 제시하였다. This paper represents the analysis and design of the generic mission operations system for next generation satellite mission. In the past, mission operations systems were developed by their own mission requirements respectively. However, these systems have the similar architecture and common functions. Mission operations systems, in general, consist of mission independent module and mission specific module. In this paper, the generic framework for the mission scheduling and automation are introduced and analyzed. Using these generic frameworks, the risk and cost for operations system development can be reduced significantly. And, these frameworks might be used for the core technology in the development of mission operations system in the future.