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Jongwon Oh,Hyung-Doo Park 대한임상검사정도관리협회 2019 Journal of Laboratory Medicine And Quality Assuran Vol.41 No.2
Background: Rheumatoid factor (RF) is used as one of the diagnostic criteria for rheumatoid arthritis. The purpose of this study was to evaluate qualitative RF reagents used in clinical laboratories in Korea, and to provide basic data that can be used as a reference to improve the quality of RF testing. Methods: We reviewed the proficiency testing results for RF from the Korean Association of External Quality Assessment Service (KEQAS) and College of American Pathologists. Moreover, we evaluated five commercially available RF qualitative reagents, including LabSlide RF (IVD Lab Co., Korea), ASAN RA Latex Reagents (Asan Pharmaceuticals Co., Korea), RaPET RF (Stanbio Laboratory, USA), RF Latex Test (Pulse Scientific Inc., Canada), and RF-100 (Teco Diagnostics, USA). Commercially available quality control materials, calibrators, and pooled sera were used in this study. The consistency of qualitative reagents and Kappa statistics were calculated based on the quantitative values of the quality control materials and the mixed sera. Results: Up to 51.5% of high concentration samples were reported as negative in KEQAS. RF qualitative reagent test results were not consistent among reagent types. The consistency of the qualitative and quantitative test results was between 51% and 100%, and the kappa statistics varied depending on the reagent manufacturer. Conclusions: Measurement of RF qualitative reagents used in domestic clinical laboratories was not consistent with the quantitative values, and hence it is necessary to improve the consistency and verify the adequacy of the cut-off value.
Assessment of 7 trace elements in serum of patients with nontuberculous mycobacterial lung disease
Oh, Jongwon,Shin, Sun Hye,Choi, Rihwa,Kim, Serim,Park, Hyung-Doo,Kim, Su-Young,Han, Sun Ae,Koh, Won-Jung,Lee, Soo-Youn Elsevier 2019 Journal of trace elements in medicine and biology Vol.53 No.-
<P><B>Abstract</B></P> <P>Nontuberculous mycobacterial (NTM) lung diseases are an emerging cause of pulmonary infection, becoming more common in the clinical setting as incidence of NTM lung diseases steadily increases worldwide. Trace elements are essential micronutrients and are known to play many important roles in infectious diseases. We investigated the concentrations of trace elements in patients with NTM lung disease and compared these values to patients with pulmonary tuberculosis and healthy controls. A case-control study was conducted to evaluate the serum trace element concentrations in 95 patients with NTM lung disease, 97 patients with pulmonary tuberculosis, and 99 healthy control subjects. The serum concentrations of 7 trace elements (cobalt, copper, chromium, manganese, molybdenum, selenium, and zinc) were measured using inductively coupled plasma-mass spectrometry. We also analyzed demographic data, clinical outcomes, and other biochemical parameters. The median serum concentrations of copper and molybdenum were higher in patients with NTM lung disease (109 vs. 91 μg/dL, p < 0.001 and 1.70 vs. 0.96 μg/L, p < 0.001). In contrast, the median serum concentrations of selenium and zinc were significantly lower in patients with NTM lung disease than in healthy controls (105 vs. 115 μg/L, p < 0.001 and 94 vs. 102 μg/dL, p < 0.001). Compared to patients with pulmonary tuberculosis, the serum concentrations of molybdenum and zinc were higher in patients with NTM lung disease, while cobalt and copper concentrations were lower (p < 0.001). Correlations among trace element concentrations were observed (copper and zinc, <I>r</I> = −0.367; cobalt and molybdenum, r = −0.360; selenium and zinc, <I>r</I> = 0.335; and manganese and zinc, <I>r</I> = 0.327, respectively). None of the 7 trace elements were associated with treatment outcomes. Patients with NTM lung disease showed different serum trace element concentrations. Our study indicates that altered trace element status is associated with mycobacterial disease. Further study investigating the clinical significance of individual trace elements and their association with nutritional status in patients with NTM lung disease would be required.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Seven trace elements (Co, Cu, Cr, Mn, Mo, Se, and Zn) were evaluated in NTM patients. </LI> <LI> Serum concentrations of Se and Zn were significantly lower in NTM patients. </LI> <LI> Cu, Se, and Zn showed correlations with CRP, albumin, and total cholesterol. </LI> <LI> The altered trace element status is associated with NTM lung disease. </LI> </UL> </P>
TRILO: A Traffic Indication-Based Downlink Communication Protocol for LoRaWAN
Oh, Youngjune,Lee, Jongwon,Kim, Chong-Kwon WILEY INTERSCIENCE 2018 WIRELESS COMMUNICATIONS AND MOBILE COMPUTING Vol.2018 No.-
<P>LPWAN (Low-Power Wide Area Network) technologies such as LoRa and SigFox are emerging as a technology of choice for the Internet of Things (IoT) applications where tens of thousands of untethered devices are deployed over a wide area. In such operating environments, energy conservation is one of the most crucial concerns and network protocols adopt various power saving schemes to lengthen device lifetimes. For example, to avoid idle listening, LoRaWAN restricts downlink communications. However, the confined design philosophy impedes the deployment of IoT applications that require asynchronous downlink communications. In this paper, we design and implement an energy efficient downlink communication mechanism, named TRILO, for LoRaWAN. We aim to make TRILO be energy efficient while obeying an unavoidable trade-off that balances between latency and energy consumption. TRILO adopts a beacon mechanism that periodically alerts end-devices which have pending downlink frames. We implement the proposed protocol on top of commercially available LoRaWAN components and confirm that the protocol operates properly in real-world experiments. Experimental results show that TRILO successfully transmits downlink frames without losses while uplink traffic suffers from a slight increase in latency because uplink transmissions should halt during beacons and downlink transmissions. Computer simulation results also show that the proposed scheme is more energy efficient than the legacy LoRaWAN downlink protocol.</P>
Optimal design of a micro parallel positioning platform. Part II: Real machine design
Oh, Kun-Ku,Liu, Xin-Jun,Kang, Deuk Soo,Kim, Jongwon Cambridge University Press 2005 Robotica Vol.23 No.1
<P>In part I of this paper (previous issue of <I>Robotica</I>) a dual stage system with the coarse and fine actuators is adopted to achieve sub-micron accuracy with a large working space for the proposed new three degree-of-freedom (DOF) miniaturized micro parallel mechanism with high mobility and one type of the architecture with vertical actuator locations in all three legs (C-VV type) among six possible coarse actuator architectures is selected for the coarse actuator architecture.</P><P>In this part of the paper, an optimal kinematic parameter set is determined for the selected coarse actuator architecture. To determine this set, the design tool of the physical model of the solution space (PMSS) and the evaluation of the conditioning index (<I>CI</I>) and global mobility conditioning index (<I>GMCI</I>) are used. The basic size of the micro parallel mechanism is 45.0 mm×22.5 mm×22.9 mm with 100° mobility, the workspace 5.0 mm (<I>y</I>-axis)×5.0 mm (<I>z</I>-axis), and sub-micron resolution. After finishing the design of the main coarse actuator architecture, one architecture among six possible fine actuator architectures is selected to achieve sub-micron positioning accuracy based on the requirements of the continuous fine motion and smaller platform resolution. The selected coarse-and-fine actuator combination is used for the micro positioning platform for laser-machining application.</P>
Oh, Sihyun,Jung, Narae,Lee, Jongwon,Kim, Jinho,Park, Ki-Min,Kang, Youngjin Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.12
Blue phosphorescent $(dfpypy)_2Ir(mppy)$, where dfpypy = 2',6'-difluoro-2,3'-bipyridine and mppy = 5-methyl-2-phenylpyridine, has been synthesized by newly developed effective method and its solid state structure and photoluminescent properties are investigated. The glass-transition and decomposition temperature of the compound appear at $160^{\circ}C$ and $360^{\circ}C$, respectively. In a crystal packing structure, there are two kinds of intermolecular interactions such as hydrogen bonding ($C-H{\cdots}F$) and edge-to-face $C-H{\cdots}{\pi}(py)$ interaction. This compound emits bright blue phosphorescence with ${\lambda}_{max}=472nm$ and quantum efficiencies of 0.23 and 0.32 in fluid and the solid state. The emission band of the compound is red-shifted by 40 nm relative to homoleptic congener, $Ir(dfpypy)_3$. The ancillary ligand in $(dfpypy)_2Ir(mppy)$ has been found to significantly destabilize HOMO energy, compared to $Ir(dfpypy)_3$, $(dfpypy)_2Ir(acac)$ and $(dfpypy)_2Ir(dpm)$, without significantly changing LUMO energy.