DLC-1 Expression Levels in Breast Cancer Assessed by qRT-PCR are Negatively Associated with Malignancy

Guan, Cheng-Nong,Zhang, Pei-Wen,Lou, Hai-Qing,Liao, Xiang-Hui,Chen, Bao-Ying Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Objective: The aim of this study was to explore the expression of DLC-l in breast carcinoma and any association with tumor metastasis. Methods: 51 surgical specimens of human breast carcinoma, divided into high invasive and low invasive groups according to their clinicopathological features, 30 cases of adjacent normal tissue and 28 benign breast lesions were examined by qRT-PCR for expression of DLC-1. Results: Expression level of DLC-1 in adjacent normal tissue and benign breast lesion specimens was higher than that in breast carcinoma (P<0.0001); the values in the high invasive group with synchronous metastases were also lower than in the low invasive group (P=0.0275). The correlation between DLC-1 expression level and tumor progression and metastasis of breast cancer was negative. Conclusion: As an anti-oncogene, DLC-1 could play an important part in breast carcinoma occurrence, progression, invasiveness and metastasis. Detecting the changes of the expression of DLC-1 in the breast carcinoma may contribute to earlier auxiliary diagnosis of invasiveness, metastasis and recrudescence.

Clinical Significance of Axin and β-catenin Protein Expression in Primary Hepatocellular Carcinomas

Guan, Cheng-Nong,Chen, Xin-Ming,Lou, Hai-Qing,Liao, Xiang-Hui,Chen, Bao-Ying,Zhang, Pei-Weng Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

The aim of the present research was to investigate clinicopathologic correlations of immunohistochemically-demonstrated axin (axis inhibition) and ${\beta}$-catenin expression in primary hepatocellular carcinomas (HCCs), in comparison with paraneoplastic, cirrhotic and normal liver tissues. Variation in Axin expression across groups were significant (P < 0.01), correlating with alpha fetoprotein (AFP), HBsAg, cancer plugs in the portal vein, and clinical stage of HCCs(P < 0.05); however, there were no links with sex, age, and tumour size (P > 0.05). Differences in cell membrane ${\beta}$-catenin expression were also statistically significant (P < 0.01), again correlated with AFP, HBsAg, cancer plugs in the portal vein, and clinical stage in HCCs (P < 0.05) but not with sex, age, and tumour size (P > 0.05). Axin expression levels in tissues with reduced membrane ${\beta}$-catenin were low (P < 0.05), also being low with nuclear ${\beta}$-catenin expression (P < 0.05). Axin and ${\beta}$-catenin may play an important role in the genesis and progression of HCC via the Wnt signal transmission pathway. Simultaneous determination of axin, ${\beta}$-catenin, AFP, and HBsAg may be useful for early diagnosis, and metastatic and clinical staging of HCCs.

论民法上处分行为之独立性

朱建農(Zhu, Jian-nong) , 权 , 承文(Quan, Cheng-wen) 조선대학교 법학연구원 2011 法學論叢 Vol.18 No.1

“처분행위”의 개념과 “처분행위독립”원칙은 독일에서의 오랜기간 민법학 연구와 입법실무의 성과이며 독일민법의 특색을 체현하고 있다. 처분행위의 개념과 유관 제도는 시장경제체제하의 민법의식 자유원칙 방면에서 강력한 도구적인 작용을 한다. 이 개념과 제도는 대륙법계민법에 중요한 영향을 일으켰으며 현대 모든 대륙법계민법학에서 중시를 돌리지 않으면 안될 위치에 이르렀다. 중국에선 지난세기 말부터 민법전 입법작업을 시작 처분행위의 이론문제에 관하여 십여년의 토론을 지속하여 왔지만 여러 가지 원인으로 이 이론에 관한 연구는 중국에서 기로에 들어설 위험에 봉착하였는바 그로 인한 입법도 불명확한 현상이 출현하였는데 이런 현상은 법학이론계의 응당한 중시를 일으켜야 하는 바이다. 비록 주도적인 이론은 물권행위의 독자성을 승인하지 않지만 입법은 “처분”개념을 대량적으로 사용하고 있으며 이미 대량적인 실제적인 “처분행위”성질의 법률행위를 규정하고 있다. 이런 상황에서 법학은 제도구조 본신의 합리성을 진지하게 검토해야 하며 의도적인 법률개념 곡해를 통해 입법상의 모순과 결함을 해석하려 해서는 안된다. 이로써 아직도 중국의 민법이론과 입법과정에는 일부 위기가 잠재해 있음을 알 수 있다. 혹은 이런 위기가 중국법학자들의 실무과정에서 이미 나타가고 있는데도 그것을 인정하지 않을 뿐이다. 물론 독립처분행위의 개념이 실제 판결과정에서 승인을 받고 이론상의 혼란을 수정하는데 관하여 입법 혹은 사법기관의 공식적인 법률문서가 필요할 뿐만 아니라 명확한 문자설명으로 새롭게 규범화 하여야만 비로소 민법체계의 완정성과 조화로움을 유지할수 있다. 이글에서는 주로 중국민법의 처분행위 독립원칙에 대한 합리적인 태도를 논하는바 사실기초, 논리의 정책기초, 체계상의 논리요구 등 세 가지 측면에서 중국민법학에서 처분행위의 독립성 응당한 의의를 회복하고 중국민법학에서 처분행위와 부담행위의 분리를 승인할 것을 제시 하는바 이는 현실적인 의의 뿐만 아니라 현행입법의 기초이기도 하기 때문이다. The concept of “Verfügungsgeschäfte” in German law is similar with the “act of disposition”. The establishment of the concept of “Verfügungsgeschäfte” and the doctrine of independence of Verfügungsgeschäfte reflecting the characteristics of German law are the great achievements of legislative practice of civil law and the success of law study in Germany. The rules and the concept related to the Verfügungsgeschäfte represent the principle of private autonomy in the market economy. In China, it is more than decade that the theory of Verfügungsgeschäfte has been argued since the beginning of the drafting of the Civil Code, but this result is still ambiguous now. In this essay, the authors holds an idea that the essential and original meaning of Verfügungsgeschäfte and the doctrine of independence of Verfügungsgeschäfte in Chinese civil law should be rediscovered and upheld. This essay consists of four parts. The first part presents a brief introduction to the concept of Verfügungsgeschäfte in Geman civil law and its exact meaning, and reveals its origin of Roman law through describing the evolution of the concept. Up to the end of 19th century when German Civil Law was drown up, the doctrine of distinction between Verfügungsgeschäfte and Verpflichtungsgeschäfte was accepted. But until the beginning of the 20th century that the precise interpretation of the Verfügungsgeschäfte was not brought to light. Later, this doctrine spreaded wide in the countries of civil law system such as Switzerland and previous ROC, etc. The concept of Verfügungsgeschäfte is attached importance in Japanese academy too, although it does not appear in Japanese Civil Law. But, what is the base or reason of distiguishing Verfügungsgeschäfte from Verpflichtungsgeschäfte? Some people think that it’s the distiction between real rights and claims, and other people think the difference of the effects of the lagel acts. This essay holds the latter, as both claims rights and dominance rights may be the objects of Verfügungsgeschäfte. So we can say that the distiguishing between real rights and claims cannot directly lead to that between Verfügungsgeschäfte and Verpflichtungsgeschäfte. In the second part, the authors discuss the relation between Verfügungsgeschäfte and right of disposition(Zuständigkeit des Verfügenden) and, further, various types of Verfügungsgeschäfte. The authors divide the Verfügungsgeschäfte into four types in accordance with the effects of Verfügungsgeschäfte. The third part is the main body of this essay. In this part, the authors introduce the present situation of Chinese legislation of civil law. There are three types of rules related to Verfügungsgeschäfte in Chinese law. The first, Real Right Law and Contract Law of China have set some rules about the legal acts which have substantial nature of Verfügungsgeschäfte, such as the transfering of earnest money and borrowing materials, giving up of rights and offsetting of debts, and performing obligation by third party, ect.. The second, there is a great number of rules in laws with the concept of Verfügungsgeschäfte. The third, there are some rules about legal acts analogous with the Verfügungsgeschäfte. The last part of the essay is the conclusion: the doctrine of independence of Verfügungsgeschäfte should beaccepted in China civil law. This conclusion is based on some reasons. The first reason is that the objective differences of the intention expressions should be recognized, and the second one, the principle of private autonomy, including the freedom of disposition of rights, as a legal ethic and legislative policy in market economy should be respected. What’s more, the recognition of the independence of

Distal Mean Nocturnal Baseline Impedance Predicts Pathological Reflux of Isolated Laryngopharyngeal Reflux Symptoms

Hua-Nong Luo,Chen-Chi Wang,Ying-Cheng Lin,Chun-Yi Chuang,Yung-An Tsou,Ja-Chih Fu,Sheng-Shun Yang,Chi-Sen Chang,Han-Chung Lien 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.2

Background/AimsDiagnosis of isolated laryngopharyngeal reflux symptoms (ILPRS), ie, without concomitant typical reflux symptoms (CTRS), remains difficult. Mean nocturnal baseline impedance (MNBI) reflects impaired mucosal integrity. We determined whether esophageal MNBI could predict pathological esophagopharyngeal reflux (pH+) in patients with ILPRS. MethodsIn this cross-sectional study conducted in Taiwan, non-erosive or low-grade esophagitis patients with predominant laryngopharyngeal reflux symptoms underwent combined hypopharyngeal multichannel intraluminal impedance-pH monitoring when off acid suppressants. Participants were divided into the ILPRS (n = 94) and CTRS (n = 63) groups. Asymptomatic subjects without esophagitis (n = 25) served as healthy controls. The MNBI values at 3 cm and 5 cm above the lower esophageal sphincter (LES) and the proximal esophagus were measured. ResultsDistal but not proximal esophageal median MNBI values were significantly lower in patients with pH+ than in those with pH– (ILPRS in pH+ vs pH–: 1607 Ω vs 2709 Ω and 1885 Ω vs 2563 Ω at 3 cm and 5 cm above LES, respectively; CTRS in pH+ vs pH–: 1476 vs 2307 Ω and 1500 vs 2301 Ω at 3 cm and 5 cm above LES, respectively, P < 0.05 for all). No significant differences of any MNBI exist between any pH– subgroups and healthy controls. The areas under the receiver operating characteristic curve in the ILPRS group were 0.75 and 0.80, compared to the pH– subgroup and healthy controls (P < 0.001 for both), respectively. Interobserver reproducibility was good (Spearman correlation 0.93, P < 0.0001). ConclusionDistal esophageal MNBI predicts pathological reflux in patients with ILPRS.

Low-dose diethylhexyl phthalate exposure does not impair the expressive patterns of epigenetics-related genes and DNA methylation of breast cancer-related genes in mouse mammary glands

Shun-Feng Cheng,Ling Li,Bo Li,Jing-Cai Liu,Fang-Nong Lai,Yong Zhao,Xi-Feng Zhang,Wei Shen,Lan Li 대한독성 유전단백체 학회 2018 Molecular & cellular toxicology Vol.14 No.2

Backgrounds: Di-(2-ethylhexyl) phthalate (DEHP), as an endocrine-disrupting chemical (EDC), is widely used in plasticizer and other productions. Ubiquitous human exposure to DEHP has been proposed to be a potential risk to public health. Developmental exposure to DEHP could alter epigenetic programming and result in adult-onset disease. Methods: In this study, we investigated whether DEHP exposure to pregnant mice affected epigenetic changes as a result of increase in breast cancer incidence. Results: Our results showed that the expression of total 143 epigenetics-related genes in mammary gland cells, have no significantly altered after short time and low-dose treated with DEHP from 0.5 days post-coitum (dpc) to 3.5 dpc of pregnant mice. DNA methylation status of some neoplastic development genes, such as EGFr, Esr1, Pgr, Fos and Rassf5 also had no obvious change. Conclusion: These finding showed no impact of DEHP on the expressive patterns of epigenetics-related genes and DNA methylation of breast cancer-related genes in pregnant mouse mammary gland cells.

중국고지도에 표기된 “페르시아만” 지명의 변화

청이농(成一農),이명희(Yi-nong Cheng) 한국고지도연구학회 2012 한국고지도연구 Vol.4 No.1

현재의 이란과 아라비아 반도 사이에 있는 만(灣)의 명칭에 대해 다년간의 논쟁이 계속되어 왔다. 어떤 사람은 당연히 “Persian Gulf(페르시아만)”이라 불러야 한다고 주장하고, 어떤 사람은 “Arabian Gulf(아라비아만)”이라 불러야 한다고 주장하고 있다. 본고는 현존하는 중국고지도와 문헌 자료를 결합해, 중국의 역사 속에서는 이 만의 명칭이 어떻게 변화했는지 살펴보았다. 현존하는 중국의 명대(明代) 중기 및 그 이전의 지도에서는 보통 이 일대 해역에 대해 아무런 표기도 하지 않았고 문헌도 역시 고유명사를 사용해 이 일대 해역을 설명한 예를 거의 찾아볼 수 없다. 당시 동남아 서쪽 지역 해역에 대한 통칭은 “西海”였다. 명대 후기, 서양의 선교사들이 중국에서 제작한 세계지도에는 이 해역이 “默生丁海(Mo Sheng Ding Hai)”와 “百兒西亞海(Bai Er Xi Ya Hai)”라고 표기되었다. 청대(淸代) 전기의 선교사들이 제작한 지도에는 주로 “百兒西亞(Bai Er Xi Ya)”라고 표기되었고, 소수의 경우만이 “阿勒富海(E Le Fu Hai)”라고 표기되기도 했다. 청대 중후기에는 중국인이 그린 지도에도 이런 음역된 용어가 사용되기 시작했다. 위원(魏源)의 『해국도지(海國圖志)』에는 또 다른 음역 단어인 “北西海(Bei Xi Hai)”가 추가되었다. 가장 늦은 시기인 19세기 중기에는 오늘날과 같은 “波斯灣(Bo Si Wan)”이라는 표기법이 사용되었고 이 단어가 일종의 표준이 되었다. 명 말기 이후 중국에서 사용된 각종 음역 단어들은 대부분 이 지역에 대한 고대 지명인 “波斯”에서 유래된 것이다. In the recent years, there has been intense controversy about the name of the gulf between Iran and the Arabian Peninsula, some people think should be called the “Persian Gulf”, others suggested that should be named the “Arabian Gulf”. Using the existing Chinese ancient map, combined with literature data, this paper recover the Gulf name in the evolution of the ancient Chinese. The existing Chinese Middle Ming Dynasty and the previous map does not label this area, and in the literature, the terminology used to represent the waters west of the waters of Southeast Asia may be collectively referred to as the “West Sea(西海)”. In the late Ming, in the world map drawn by the missionaries, this sea area was marked as “默生丁海” and “百儿西亚海”. Map drawn by missionaries in the early Qing Dynasty , this sea area is mainly named by “百儿西亚”, and in a few cases to use “阿勒富海”. In the Map drawn by the late Qing Dynasty, Chinese people have begun to use the these transliteration vocabulary, Wei Yuan(魏源)《海国图志》 added another transliteration - “北西海”. In the mid -19th century, began to use this translation of the “Persian Gulf”, and basically become a standard. Since the late Ming , the transliteration of the name of this area largely from the ancient vocabulary related to the geographical name “Persian”.

Association of the Single-Nucleotide Polymorphism and Haplotype of the Complement Receptor 1 Gene with Malaria

Yan Lan,Le-Gen Nong,Chuan-Dong Wei,Wen-Cheng Chen,Jun-Li Wang,Chun-Fang Wang,Guo-Gang Pan,Ye-Sheng Wei 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.2

Purpose: Although the polymorphisms of erythrocyte complement receptor type 1 (CR1) in patients with malaria have been extensively studied, a question of whether the polymorphisms of CR1 are associated with severe malaria remains controversial. Furthermore, no study has examined the association of CR1 polymorphisms with malaria in Chinese population. Therefore, we investigated the relationship of CR1 gene polymorphism and malaria in Chinese population. Materials and Methods:We analyzed polymorphisms of CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T in 509 patients with malaria and 503 controls, using the Taqmangenotyping assay and PCR-direct sequencing. Results: There were no significantdifferences in the genotype, allele and haplotype frequencies of CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T polymorphisms between patientswith malaria and controls. Furthermore, there was no association of polymorphismsin the CR1 gene with the severity of malaria in Chinese population. Conclusion:These findings suggest that CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T polymorphisms may not be involved in susceptibility to malariain Chinese population.

论民法上处分行为之独立性

朱建農(Zhu, Jian-nong),权,承文(Quan, Cheng-wen) 조선대학교 법학연구원 2011 法學論叢 Vol.18 No.1

The concept of “Verfügungsgeschäfte” in German law is similar with the “act of disposition”. The establishment of the concept of “Verfügungsgeschäfte” and the doctrine of independence of Verfügungsgeschäfte reflecting the characteristics of German law are the great achievements of legislative practice of civil law and the success of law study in Germany. The rules and the concept related to the Verfügungsgeschäfte represent the principle of private autonomy in the market economy. In China, it is more than decade that the theory of Verfügungsgeschäfte has been argued since the beginning of the drafting of the Civil Code, but this result is still ambiguous now. In this essay, the authors holds an idea that the essential and original meaning of Verfügungsgeschäfte and the doctrine of independence of Verfügungsgeschäfte in Chinese civil law should be rediscovered and upheld. This essay consists of four parts. The first part presents a brief introduction to the concept of Verfügungsgeschäfte in Geman civil law and its exact meaning, and reveals its origin of Roman law through describing the evolution of the concept. Up to the end of 19th century when German Civil Law was drown up, the doctrine of distinction between Verfügungsgeschäfte and Verpflichtungsgeschäfte was accepted. But until the beginning of the 20th century that the precise interpretation of the Verfügungsgeschäfte was not brought to light. Later, this doctrine spreaded wide in the countries of civil law system such as Switzerland and previous ROC, etc. The concept of Verfügungsgeschäfte is attached importance in Japanese academy too, although it does not appear in Japanese Civil Law. But, what is the base or reason of distiguishing Verfügungsgeschäfte from Verpflichtungsgeschäfte? Some people think that it’s the distiction between real rights and claims, and other people think the difference of the effects of the lagel acts. This essay holds the latter, as both claims rights and dominance rights may be the objects of Verfügungsgeschäfte. So we can say that the distiguishing between real rights and claims cannot directly lead to that between Verfügungsgeschäfte and Verpflichtungsgeschäfte. In the second part, the authors discuss the relation between Verfügungsgeschäfte and right of disposition(Zuständigkeit des Verfügenden) and, further, various types of Verfügungsgeschäfte. The authors divide the Verfügungsgeschäfte into four types in accordance with the effects of Verfügungsgeschäfte. The third part is the main body of this essay. In this part, the authors introduce the present situation of Chinese legislation of civil law. There are three types of rules related to Verfügungsgeschäfte in Chinese law. The first, Real Right Law and Contract Law of China have set some rules about the legal acts which have substantial nature of Verfügungsgeschäfte, such as the transfering of earnest money and borrowing materials, giving up of rights and offsetting of debts, and performing obligation by third party, ect.. The second, there is a great number of rules in laws with the concept of Verfügungsgeschäfte. The third, there are some rules about legal acts analogous with the Verfügungsgeschäfte. The last part of the essay is the conclusion: the doctrine of independence of Verfügungsgeschäfte should beaccepted in China civil law. This conclusion is based on some reasons. The first reason is that the objective differences of the intention expressions should be recognized, and the second one, the principle of private autonomy, including the freedom of disposition of rights, as a legal ethic and legislative policy in market economy should be respected. What’s more, the recognition of the independence of “처분행위”의 개념과 “처분행위독립”원칙은 독일에서의 오랜기간 민법학 연구와 입법실무의 성과이며 독일민법의 특색을 체현하고 있다. 처분행위의 개념과 유관 제도는 시장경제체제하의 민법의식 자유원칙 방면에서 강력한 도구적인 작용을 한다. 이 개념과 제도는 대륙법계민법에 중요한 영향을 일으켰으며 현대 모든 대륙법계민법학에서 중시를 돌리지 않으면 안될 위치에 이르렀다. 중국에선 지난세기 말부터 민법전 입법작업을 시작 처분행위의 이론문제에 관하여 십여년의 토론을 지속하여 왔지만 여러 가지 원인으로 이 이론에 관한 연구는 중국에서 기로에 들어설 위험에 봉착하였는바 그로 인한 입법도 불명확한 현상이 출현하였는데 이런 현상은 법학이론계의 응당한 중시를 일으켜야 하는 바이다. 비록 주도적인 이론은 물권행위의 독자성을 승인하지 않지만 입법은 “처분”개념을 대량적으로 사용하고 있으며 이미 대량적인 실제적인 “처분행위”성질의 법률행위를 규정하고 있다. 이런 상황에서 법학은 제도구조 본신의 합리성을 진지하게 검토해야 하며 의도적인 법률개념 곡해를 통해 입법상의 모순과 결함을 해석하려 해서는 안된다. 이로써 아직도 중국의 민법이론과 입법과정에는 일부 위기가 잠재해 있음을 알 수 있다. 혹은 이런 위기가 중국법학자들의 실무과정에서 이미 나타가고 있는데도 그것을 인정하지 않을 뿐이다. 물론 독립처분행위의 개념이 실제 판결과정에서 승인을 받고 이론상의 혼란을 수정하는데 관하여 입법 혹은 사법기관의 공식적인 법률문서가 필요할 뿐만 아니라 명확한 문자설명으로 새롭게 규범화 하여야만 비로소 민법체계의 완정성과 조화로움을 유지할수 있다. 이글에서는 주로 중국민법의 처분행위 독립원칙에 대한 합리적인 태도를 논하는바 사실기초, 논리의 정책기초, 체계상의 논리요구 등 세 가지 측면에서 중국민법학에서 처분행위의 독립성 응당한 의의를 회복하고 중국민법학에서 처분행위와 부담행위의 분리를 승인할 것을 제시 하는바 이는 현실적인 의의 뿐만 아니라 현행입법의 기초이기도 하기 때문이다.

QTL mapping and identification of candidate genes for cold tolerance at the germination stage in wild rice

Pan Ying-Hua,Nong Bao-Xuan,Chen Lei,Yang Xing-Hai,Xia Xiu-Zhong,Zhang Zong-Qiong,Qing Dong-Jin,Gao Ju,Huang Cheng-Cui,Li Dan-Ting,Deng Guo-Fu 한국유전학회 2023 Genes & Genomics Vol.45 No.7

Background Cold damage stress significantly affects rice growth (germination and seedling) and causes serious losses in yield in temperate and high-altitude areas around the globe. Objective This study aimed to explore the cold tolerance (CT) locus of rice and create new cold-tolerant germplasm. We constructed a chromosome segment substitution line (CSSL) with strong CT and fine mapped quantitative trait loci (QTLs) associated with CT by performing the whole-genome resequencing of CSSL with phenotypes under cold treatment. Methods A chromosome CSSL, including 271 lines from a cross between the cold-tolerant wild rice Y11 (Oryza rufipogon Griff.) and the cold-sensitive rice variety GH998, was developed to map QTLs conferring CT at the germination stage. The whole-genome resequencing was performed on CSSL for mapping QTLs of associated with CT at the germination stage. Results A high-density linkage map of the CSSLs was developed using the whole-genome resequencing of 1484 bins. The QTL analysis using 615,466 single-nucleotide polymorphisms (SNPs) led to the identification of 2 QTLs related to germination rate at low-temperature on chromosome 8 (qCTG-8) and chromosome 11 (qCTG-11). The qCTG-8 and qCTG-11 explained 14.55% and 14.31% of the total phenotypic variation, respectively. We narrowed down qCTG-8 and qCTG-11 to 195.5 and 78.83-kb regions, respectively. The expression patterns of important candidate genes in different tissues, and of RNA-sequencing (RNA-seq) in CSSLs, were identified based on gene sequences in qCTG-8 and qCTG-11 cold-induced expression analysis. LOC_Os08g01120 and LOC_Os08g01390 were identified as candidate genes in qCTG-8, and LOC_Os11g32880 was identified as a candidate gene in qCTG-11. Conclusions This study demonstrated a general method that could be used to identify useful loci and genes in wild rice and aid in the future cloning of candidate genes of qCTG-8 and qCTG-11. The CSSLs with strong CT were supported for breeding cold-tolerant rice varieties.

Research on Modeling Improvement of Rubber Isolators by Considering Multi-loading Conditions

Yin-Yan Zhao,Wen-Bin Shangguan,Nong Cheng,Xiao-Jing He 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.

The stress-strain relationships of a rubber material in uniaxial tension, equi-biaxial tension and plane shear loading conditions are tested here. Constitutive parameters in different constitutive models, such as Mooney-Rivlin model, Van Der Waals model and Marlow model can be obtained by least square method using measured and calculated stress-strain relations. The rubber isolators in two rubber mounts are investigated here. Rubber mount I bears stretching/compression deformation or shear deformation, while mount II bears both deformations simultaneously. Using obtained constitutive constants, the rubber isolators’ static stiffness values in three mutually perpendicular directions are calculated, analyzed and compared with their measured results. Based on Mooney-Rivlin model, the effects of these constitutive constants on static stiffness of the two mounts are discussed by comparison. The effects of different models on static force-displacement characteristics of rubber mount I are also analyzed. The conclusion is that it is necessary to choose a relatively accurate constitutive model and appropriate methods for obtaining the model constants in describing rubber characteristic.