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호흡쇄의 NADH - ubiquinone oxidoreductase 저해제인 합성 piericidin 유사체들의 살균활성
조광연,정근회,다까하시노부다까,요시다시게오 한국농화학회 1990 Applied Biological Chemistry (Appl Biol Chem) Vol.33 No.3
Representative synthetic piericidin-like compounds, such as hydroxypyridine and hydroxyquinoline derivatives, which showed high inhibition activity against NADH-ubiquinone oxidoreductase on the respiratory chain revealed good fungicide activity. Especially, hydroxypyridine ores showed high activity against rice blast (Pyricularia oryzae) and barley powdery mildew (Erysiphe graminis) (Received August l3, accepted September 20, 1990).
NADH - ubiquinone oxidoreductase 저해제인 quinoline 유도체들의 생리활성
조광연,정근회,다까하시노부다까,요시다시게오 한국농화학회 1991 Applied Biological Chemistry (Appl Biol Chem) Vol.34 No.1
New quinoline compounds were designed, synthesized, and examined with sub mitochondria. Most compounds showed high activity against NADH-ubiquinone oxidoreductase. Inhibition activity was mainly affected by the length of the lipophilic part, regardless of bulkiness or to ration of a phenyl group in the side chain. The β-methyl group was demonstrated to be the optimal functionality on tire nuclei of the quinoline derivatives so that either deletion or insertion of a methyiene on the group eliminated its activity(Received January 25, 1991, Accepted Mach 25, 1991).
Munetaka Takekuma,Shiho Kuji,Aki Tanaka,Nobutaka Takahashi,Masakazu Abe,Yasuyuki Hirashima 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.3
Objective: The concept of platinum sensitivity and cross-resistance among platinum agents are widely known in the management of recurrent ovarian cancer. The aim of this study was to evaluate two hypotheses regarding the validity of the concept of platinum sensitivity and non-cross-resistance of cisplatin analogue with cisplatin in recurrent cervical cancer. Methods: In this retrospective study, the clinical data of patients with recurrent cervical cancer, who had a history of receiving cisplatin based chemotherapy (including concurrent chemoradiotherapy [CCRT] with cisplatin) and who received second-line chemotherapy at the time of recurrence between April 2004 and July 2012 were reviewed. Results: In total, 49 patients―34 squamous cell carcinomas (69.4%) and 15 non-squamous cell carcinomas (30.6%)―were enrolled. The median age was 53 years (range, 26 to 79 years). Univariate and multivariate analysis showed that a platinum free interval (PFI) of 12 months has a strong relationship with the response rate to second-line chemotherapy. Upon multivariate analysis of survival after second-line platinum-based chemotherapy, a PFI of 12 months significantly influenced both progression-free survival (hazard ratio [HR], 0.349; 95% confidence interval [CI], 0.140 to 0.871; p=0.024) and overall survival (HR, 0.322; 95% CI, 0.123 to 0.842; p=0.021). In patients with a PFI of less than 6 months, the difference of progression-free survival between patients with re-administration of cisplatin (3.0 months) and administration of cisplatin analogue (7.2 months) as second-line chemotherapy was statistically significant (p=0.049, log-rank test). Conclusion: The concept of platinum sensitivity could be applied to recurrent cervical cancer and there is a possibility of noncross- resistance of cisplatin analogue with cisplatin.
김성기(Seong Ki Kim),횡전효웅(Takao Yokota),고교신효(Nobutaka Takahashi) 한국식물학회 1994 Journal of Plant Biology Vol.37 No.4
In immature seeds of Phaseolus vulgaris, the presence of three new 2-deoxy type brassinosteroids (trihydroxybrassinosteroids) have been demonstrated. These less polar brassinosteroids have been tentatively characterized to be (3ξ, 22ξ, 23ξ)-2-deoxy-25-methyldolicholide, (3ξ, 22ξ, 23ξ)-2-deoxy-dolichosterone and (3ξ, 22ξ, 23)-2-deoxy-24-ethylbrassinone by analysis of gas chromatography-mass spectrometry. Their less biological activity and oxidation state than those of tetrahydroxybrassionosteroids suggest that they are potent biosynthetic precusors of tetrahydroxybrassinosteroids.
Shiho Kuji,Yasuyuki Hirashima,Satomi Komeda,Aki Tanaka,Masakazu Abe,Nobutaka Takahashi,Munetaka Takekuma 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.2
Objective: The purpose of this study was to assess whether peritoneal cytology has prognostic significance in uterine cervical cancer. Methods: Peritoneal cytology was obtained in 228 patients with carcinoma of the uterine cervix (International Federation of Gynecology and Obstetrics [FIGO] stages IB1-IIB) between October 2002 and August 2010. All patients were negative for intraperitoneal disease at the time of their radical hysterectomy. The pathological features and clinical prognosis of cases of positive peritoneal cytology were examined retrospectively. Results: Peritoneal cytology was positive in 9 patients (3.9%). Of these patients, 3/139 (2.2%) had squamous cell carcinoma and 6/89 (6.7%) had adenocarcinoma or adenosquamous carcinoma. One of the 3 patients with squamous cell carcinoma who had positive cytology had a recurrence at the vaginal stump 21 months after radical hysterectomy. All of the 6 patients with adenocarcinoma or adenosquamous carcinoma had disease recurrence during the follow-up period: 3 with peritoneal dissemination and 2 with lymph node metastases. There were significant differences in recurrence-free survival and overall survival between the peritoneal cytology-negative and cytology-positive groups (log-rank p<0.001). Multivariate analysis of prognosis in cervical cancer revealed that peritoneal cytology (p=0.029) and histological type (p=0.004) were independent prognostic factors. Conclusion: Positive peritoneal cytology may be associated with a poor prognosis in adenocarcinoma or adenosquamous carcinoma of the uterine cervix. Therefore, the results of peritoneal cytology must be considered in postoperative treatment planning.