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Yusuke Uchinami(Yusuke Uchinami ),Koichi Yasuda(Koichi Yasuda ),Hideki Minatogawa(Hideki Minatogawa ),Yasuhiro Dekura(Yasuhiro Dekura ),Noboru Nishikawa(Noboru Nishikawa ),Rumiko Kinoshita(Rumiko Kino 대한방사선종양학회 2024 Radiation Oncology Journal Vol.42 No.1
Purpose: To investigate the clinical significance of adaptive radiotherapy (ART) in locally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT). Materials and Methods: Eligible patients were treated with concurrent chemoradiotherapy using IMRT. Planning computed tomography in ART was performed during radiotherapy, and replanning was performed. Since ART was started in May 2011 (ART group), patients who were treated without ART up to April 2011 (non-ART group) were used as the historical control. The Kaplan-Meier method was used to calculate overall survival (OS), locoregional recurrence-free survival (LRFS), progression-free survival (PFS), and distant metastasis-free survival (DMFS). LRFS for the primary tumor (LRFS_P) and regional lymph node (LRFS_LN) were also studied for more detailed analysis. Statistical significance was evaluated using the log-rank test for survival. Results: The ART group tended to have higher radiation doses. The median follow-up period was 127 months (range, 10 to 211 months) in the non-ART group and 61.5 months (range, 5 to 129 months) in the ART group. Compared to the non-ART group, the ART group showed significantly higher 5-year PFS (53.8% vs. 81.3%, p = 0.015) and LRFS (61.2% vs. 85.3%, p = 0.024), but not OS (80.7% vs. 80.8%, p = 0.941) and DMFS (84.6% vs. 92.7%, p = 0.255). Five-year LRFS_P was higher in the ART group (61.3% vs. 90.6%, p = 0.005), but LRFS_LN did not show a significant difference (91.9% vs. 96.2%, p = 0.541). Conclusion: Although there were differences in the patient backgrounds between the two groups, this study suggests the potential effectiveness of ART in improving locoregional control, especially in the primary tumor.
Naohiro Nishikawa,Katsuhiko Omoe,Kenji Murakami,Yusuke Sato,Takekazu Sawa,Yoshihiro Hagihara,Nobuhito Yoshihara,Hiroaki Okawai,Toshirou Iyama,Masahiro Mizuno,Shinya Tsukamoto 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.
It is great concern that is environmental load in manufacturing. In machining site, metal working fluid (coolant) such as cutting oil,grinding fluid is used. It contains several chemicals that are oil, surface active agent, extreme pressure additive, antirust agent,antifoaming agent, preservative, biocide etc.. It is thought that it is not good for environment and human body. Machining fluid mist and splash contained several chemicals that are cause of danger for worker’s health while machining. Furthermore, time elapses, fluid is rotten by bacteria. Bad smell and degradation of machining performance occurs. Therefore, after using machining fluid, waste fluid is disposed. Incineration or coagulative precipitation and landfill etc. are necessary. It arise great disposal cost and environmental load as discharging of huge amount green house gas (CO2 etc.). Then, machining fluid decreasing or non-using is demanded in industry. So, in this investigation, new environmental machining method: the electric rust preventive machining method system that uses only water as machining fluid has been developed. In this paper, water purification recycle system in water machining system development is mentioned. Therefore, complete removal of bacteria (Enterobacter aerogenes) without using chemicals such as biocide is examined for corruption, malodor prevention and safe machining water.
Novel angular evaluation method for radiation field using Lie derivative
Anetai Yusuke,Kinami Shinji,Koike Yuhei,Kamojima Takeo,Yokoi Masanori,Nishikawa Toshiyuki,Hirokawa Keiko,Ishii Yoshie,Takegawa Hideki 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.81 No.11
In radiotherapy, quality assurance (QA) for beam delivery from linear accelerator (linac) of treatment machine is a highly crucial factor for accurate radiotherapy because of the fuctuations in the conditions of the machine. The radiation feld is one of the important evaluation items, and this has been well-checked by crossline (right-to-left) and inline (caudal-to-cranial) profles. Diagonal or angular profles of the radiation feld are also an important component of irradiation feld; however, these are frequently omitted or not fully taken into account as it requires inefcient measurements. To detect the angular and radial conditions of the radiation feld, we proposed a novel evaluation method using Lie derivative analysis against radiochromic flm dosimetry in this study. This method directly compared the detected dose distributions with the calculations, obtained the discrepancy of the fow feld from the mathematical characteristic of Lie derivative, resulted in a detection of the radial and angular discrepancies that have not been handled by conventional gamma analysis.
Shibata Teishiki,Oomura Masahiro,Nishikawa Yusuke,Mase Mitsuhito 대한신경중재치료의학회 2020 Neurointervention Vol.15 No.1
In mechanical endovascular thrombectomy (MET) for acute basilar artery occlusion (ABAO) in the elderly, navigating a guide catheter via the femoral artery may be difficult due to the approach route’s significant tortuosity. To resolve this problem, we have been performing a technique that uses a direct brachial approach (DiBA) with a large-bore aspiration catheter. We reported our preliminary clinical experience with this technique. MET for ABAO using the DiBA technique was performed on 4 consecutive patients between August 2017 and December 2018. In all patients, thrombolysis in cerebral infarction 2B or 3 recanalization was achieved, but the modified Rankin Scale at 90 days was ≥4. There were no technical difficulties or complications with this technique. The DiBA technique is an effective and feasible approach in MET for ABAO. Although excellent clinical outcomes could not be achieved, the angiographic outcomes were excellent with no technical complications. This approach can be an alternative to the femoral artery approach, particularly for tortuous arteries in the elderly.