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^31P-NMR Spectroscopy Evaluation of the Human Masseter Muscle in Normal and Bruxing Subjects
Negoro, Takefumi,Marcel, Tom,McNeill, Charles,Hatcher, David,Chew, Wilbert,Hiraba, Katsunari,Goto, Shigemi,Miller, Arthur J. Korean Academy of Oral Biology and the UCLA Dental 2001 International Journal of Oral Biology Vol.26 No.2
^31P magnetic resonance spectroscopy provides a noninvasive tool to assess muscle metabolism during rest, exercise, and recovery. Each averaged spectrum demonstrated seven peaks: phosphomonoester(PME), inorganic phosphate(Pi), phosphodiester(PDE), creatine phosphate(PCr), and γ-,α-,β- phosphorus nuclei of ATP. Abnormal PME or PDE levels can characterize muscle disease and function. It was investigated as to whether these two substances, and the relationship between Pi/PCr and pH, were at different levels in young adult bruxing subjects versus normal young adults. During contraction of the masseter muscle involved with chewing or clenching, the PCr peak would diminish while the Pi peak would increase. Ecpressing changes in Pi, PCr, PME and PDE to the total phosphate(total P) that includes these four spectra and the three ATP peaks, indicates a percentage change for each of the separate components. The Pi/total P ratio increased, and the PCr/total P ratio decreased significantly during chewing and clenching in both groups. Changes in PME and PDE were similar for the control and bruxing subjects. Pi/PCr increased as pH decreased in both the control and bruxing subjects. In the control subjects, the Pi/PCr ratio during. The correlation coefficient of a linear regression analysis between Pi/PCr and pH was significantly lower in bruxing subjects (r=-0.643) than that of control subjects (r=-0.864). These findings suggests the concept that metabolism of masseter muscle in bruxing subjects may not perform similarly to normal subjects but similar changes in PME and PDE to control subjects. Also it is considered the possibility that the rapid decline in pH in bruxing subjects may have been associated with the development of muscle fatigue.
나카하라 주야와 윤동주 - “고향 (故郷)”이라는 내 무덤 -
네고로유키 ( Negoro Yuki ) 전북대학교 인문학연구소 2021 건지인문학 Vol.- No.32
나카하라 주야와 윤동주는 생년이 10년, 자란 곳도 다르지만, 시의 유사한 서정성은 자주 지적되고 있다. 주요 이유는 윤동주가 일본시잡지 ‘사계(四季)’를 애독한 흔적이 있고, 주야가 일본에서 ‘사계’ 동인시인, 즉 사계파(四季派) 시인으로 유명하는 점을 들 수 있다. 이 논문은 윤동주가 주야의 시를 읽었다고 생각된 1941년 이후에 윤동주가 쓴 시중에서 ‘또다른 고향’을 중심으로 주야 시와 비교한다. 우선 ‘또 다른 고향’과 “나”, “백골”, “혼”의 3요소가 같은 주야의 시 ‘뼈 (骨)”를 비교해서 “나”가 어떻게 분화하고 묘사되는 것을 확인한다. 그리고 분화된 또 다른 “나”인 “백골”이 있는 “고향”이라는 장소에 대해 주야의 시 ‘귀향 (帰郷)”과 같이 읽음으로 해서 윤동주에게 있어서의 일탈 불가능한 “고향”의 순환성와 거기에 매장된 “나”에 대해 논한다. Nakahara Chuya and Yun Dong-ju were born and raise differently, but it has been pointed out that the lyricism of their poems are similar. The biggest reason of this indication is there is evidence that Yun Dong-ju loved to read Japanese poetry magagine ‘Shiki (四季),’ and it is very popular in Japan that Chuya is one of the poet who contributed his work to ‘Shiki.’ That is why, I would like to focus on ‘A Different Hometown’ from the works written after 1941, when Yun Dong-ju is believed to have read Chuya’s work. First, I would like to compare “A Different Hometown” with Chuya's ‘A Bone (骨),’ which is said to have the three similar elements of “I,” “Bone,” and “Soul,” to see how “I” is differentiated and depicted. In addition, I will discuss the “hometown” where “Bone,” another differentiated “I,” are left behind, and by reading it together with Chuya's “Homecoming (帰郷),” I will discuss the circularity of “hometown,” which is impossible to deviate from for Yun Dong-ju, and the “I” that is buried there.
Anti-Müllerian hormone as a predictor of polycystic ovary syndrome treated with clomiphene citrate
Hestiantoro, Andon,Negoro, Yuwono Sri,Afrita, Yohana,Wiweko, Budi,Sumapradja, Kanadi,Natadisastra, Muharam The Korean Society for Reproductive Medicine 2016 Clinical and Experimental Reproductive Medicine Vol.43 No.4
Objective: This study aimed to determine the threshold of $anti-M{\ddot{u}}llerian$ hormone (AMH) as predictor of follicular growth failure in polycystic ovary syndrome (PCOS) patients treated with clomiphene citrate (CC). Methods: Fifty female subjects with PCOS were recruited and divided into two groups based on successful and unsuccessful follicular growth. Related variables such as age, infertility duration, cigarette smoking, use of Moslem hijab, sunlight exposure, fiber intake, body mass index, waist circumference, AMH level, 25-hydroxy vitamin D level, and growth of dominant follicles were obtained, assessed, and statistically analyzed. Results: The AMH levels of patients with successful follicular growth were significantly lower (p= 0.001) than those with unsuccessful follicular growth ($6.10{\pm}3.52$ vs. $10.43{\pm}4.78ng/mL$). A higher volume of fiber intake was also observed in the successful follicular growth group compared to unsuccessful follicular growth group (p= 0.001). Our study found the probability of successful follicle growth was a function of AMH level and the amount of fiber intake, expressed as Y =-2.35+($-0.312{\times}AMH\;level$)+($0.464{\times}fiber\;intake$) (area under the curve, 0.88; 95% confidence interval, 0.79-0.98; p< 0.001). Conclusion: The optimal threshold of AMH level in predicting the failure of follicle growth in patients with PCOS treated with CC was 8.58 ng/mL.
( Eiki Nomura ),( Yoshitaka Kinouchi ),( Tooru Shimosegawa ),( Sho Takagi ),( Hisashi Shiga ),( Nobuya Obana ),( Katsuya Endo ),( Nobuo Ueki ),( Kenichi Negoro ),( Seichi Takahashi ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Cronkhite-Canada syndrome (CCS) is a rare nonhereditary disorder with gastrointestinal (GI) polyposis, associated with ectodermal changes. GI polyps are generally accepted to be nonneoplastic in nature. However, GI malignancy have been described in some CCS patients. Methods: Two cases of CCS associated with GI cancer and membranous glomerulonephritis (MGN) were examined about clinicopathological features. Results: 〔Case 1〕 A 71-year-old man had GI polyposis. The skin of his legs showed brown pigmentation and his fingernails and toenails were atrophic. He had proteinuria and the biopsied specimen of the kidney revealed MGN. We made a diagnosis of CCS associated with MGN. Treatment with methylprednisolone and cyclosporine ameliorated the symptoms and the GI polyposis Colonoscopy after the treatment showed the regression of the polyposis and the histological examination of the remnant polyp after endoscopic resection showed well differentiated adenocarcinoma. Twelve months after the resection, he achieved remission and no recurrence of the polyposis was found. 〔Case 2〕 A 58-year-old man was admitted our hospital for the examination of the progression of anemia. HE was diagnosed as MGN at 24 years old and was under medical treatment. He had poor nutrition, with the typical clinical features of CCS. He had also taste disturbance. Radiologic, endoseopic and histological examinations confirmed CCS polyposis in the stomach, small intestine and colon. He was treated with prednisolone, oral zinc and tranexamic acid and was improved of the symptoms. Six months after the diagnosis, follow-up upper GI scopy showed no change of the diffuse polyposis of the stomach, whereas the histological findings of the biopsied specimens from the lower body polyp revealed to be an adenocarcinoma. He was performed a total gastrectomy. Conclusions: Although the frequency of malignant transformation is considered to be low in CCS, it has definite malignant potential and a close follow-up examination is recommended.