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- 저자 : Neelakandan, Karthik (검색결과 4 건)
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Neelakandan Yuvaraj,Paulraj Kanmani,Ramraj Satishkumar,Alagesan Paari,Vellaiyan Pattukumar,Venkatesan Arul 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.8
The present study investigated the effects of sulfated polysaccharides from brown seaweed Sargassum wightii (Sw-SP) and seagrass Halophila ovalis (Ho-SP) in nociceptive and inflammatory models. In the formalin test, Sw-SP and Ho-SP significantly reduced licking time in both phases of the test at a dose of 10 mg/kg. In the hot plate test, the antinociceptive effect was observed only in animals treated with 10 mg/kg of Sw-SP and 5, 10 mg/kg of Ho-SP, suggesting that the analgesic effect occurs through a central action mechanism at the higher dose. Sw-SP and Ho-SP (10 mg/kg) significantly inhibited paw edema induced by carrageenan, especially at 3 h after treatment and potentially decreased neutrophil migration by 53% and 52%, respectively. In Freund’s adjuvant-induced arthritic rats, there was a significant increase in the rat paw volume and decrease in body weight, but in Sw-SP- and Ho-SP-treated groups (10 mg/kg), a significant reduction in paw volume and a normal gain in body weight were observed. The present results indicate that Sw-SP and Ho-SP possess antinociceptive and anti-inflammatory effects and have potential usefulness for development as therapeutic agents.
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Panigrahi, Stuti,Pardeshi, Varsha Chhotusing,Chandrasekaran, Karthikeyan,Neelakandan, Karthik,PS, Hari,Vasudevan, Anil The Korean Pediatric Society 2021 Clinical and Experimental Pediatrics (CEP) Vol.64 No.7
Background: Nephrotic syndrome (NS) is a common renal disorder in children attributed to podocyte injury. However, children with the same diagnosis have markedly variable treatment responses, clinical courses, and outcomes, suggesting molecular heterogeneity. Purpose: This study aimed to explore the molecular responses of podocytes to nephrotic plasma to identify specific genes and signaling pathways differentiating various clinical NS groups as well as biological processes that drive injury in normal podocytes. Methods: Transcriptome profiles from immortalized human podocyte cell line exposed to the plasma of 8 subjects (steroid-sensitive nephrotic syndrome [SSNS], n=4; steroid-resistant nephrotic syndrome [SRNS], n=2; and healthy adult individuals [control], n=2) were generated using microarray analysis. Results: Unsupervised hierarchical clustering of global gene expression data was broadly correlated with the clinical classification of NS. Differential gene expression (DGE) analysis of diseased groups (SSNS or SRNS) versus healthy controls identified 105 genes (58 up-regulated, 47 down-regulated) in SSNS and 139 genes (78 up-regulated, 61 down-regulated) in SRNS with 55 common to SSNS and SRNS, while the rest were unique (50 in SSNS, 84 genes in SRNS). Pathway analysis of the significant (P≤0.05, -1≤ log2 FC ≥1) differentially expressed genes identified the transforming growth factor-β and Janus kinase-signal transducer and activator of transcription pathways to be involved in both SSNS and SRNS. DGE analysis of SSNS versus SRNS identified 2,350 genes with values of P≤0.05, and a heatmap of corresponding expression values of these genes in each subject showed clear differences in SSNS and SRNS. Conclusion: Our study observations indicate that, although podocyte injury follows similar pathways in different clinical subgroups, the pathways are modulated differently as evidenced by the heatmap. Such transcriptome profiling with a larger cohort can stratify patients into intrinsic subtypes and provide insight into the molecular mechanisms of podocyte injury.
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Paulraj Kanmani,Venkatesan Arul,Ramraj Satishkumar,Neelakandan Yuvaraj,Kupusamy Alagesan Paari,Vellaiyan Pattukumar 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.3
The aim of this study was to optimize medium composition for higher yield of total viable cells and bacteriocin by Enterococcus faecium MC13. The factors such as peptone, meat extract, yeast extract, lactose, glycerol, tween 80,triammonium citrate and K-2HPO_4 were selected based on the Lactobacillus MRS medium composition. Two level factorial designs (FD) and steepest ascent path were performed to identify vital factors among the variables. Through the 2^(−8)FD, peptone, yeast extract and lactose were found to be significant factors involved in the enhanced production of viable cells and bacteriocin. Therefore, these three foremost factors were further optimized by central composite design to achieve efficient yield. The optimum MRS composition was found to be peptone (40.0 g/L), meat extract (30.0 g/L),yeast extract (40.0 g/L), lactose (24.0 g/L), glycerol (5.8 g/L), Tween 80 (3.0 g/L), triammonium citrate (1.0 g/L), K_2HPO_4(2.5 g/L), MgSO_4·7H_2O (0.10 g/L), MnSO-4·7H_2O (0.05 g/L) and dipotassium PO_4 (2.0 g/L). The optimized growth medium allowed higher amount of bacteriocin activity (36,100 AUml^(−1)) and total viable cells (14.22 LogCFUml^(−1))production which were two-times higher than the commercial MRS medium.
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Palsamy Kanagaraj,Alagumalai Nagendran,Sivasubramaniyan Neelakandan 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.6
A charged surface modifying macromolecule (cSMM) was synthesized, characterized by FT-IR spectroscopyand blended into the casting solution of cellulose acetate (CA) to prepare surface modified UF membranesby phase inversion technique. With an increasing cSMM additive content from 1 to 4 wt%, pure water flux (PWF)and water content (WC) were increases whereas the hydraulic resistance decreases. Surface characteristic study revealsthat the surface hydrophilicity increased in cSMM modified CA membranes. The pore size and surface porosity ofthe 4 wt% cSMM blend CA membranes increases to 41.26 Å and 0.015%, respectively. Similarly, the molecular weightcut-off (MWCO) of the membranes ranged from 20 to 45 kDa, depending on the various compositions of the preparedmembranes. Lower flux decline rate (47.2%) and higher flux recovery ratio (FRR) (89.0%), exhibited by 4 wt% cSMMblend membranes demonstrated its fouling resistant characteristic compared to pristine CA membrane.
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