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Neelakandan Yuvaraj,Paulraj Kanmani,Ramraj Satishkumar,Alagesan Paari,Vellaiyan Pattukumar,Venkatesan Arul 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.8
The present study investigated the effects of sulfated polysaccharides from brown seaweed Sargassum wightii (Sw-SP) and seagrass Halophila ovalis (Ho-SP) in nociceptive and inflammatory models. In the formalin test, Sw-SP and Ho-SP significantly reduced licking time in both phases of the test at a dose of 10 mg/kg. In the hot plate test, the antinociceptive effect was observed only in animals treated with 10 mg/kg of Sw-SP and 5, 10 mg/kg of Ho-SP, suggesting that the analgesic effect occurs through a central action mechanism at the higher dose. Sw-SP and Ho-SP (10 mg/kg) significantly inhibited paw edema induced by carrageenan, especially at 3 h after treatment and potentially decreased neutrophil migration by 53% and 52%, respectively. In Freund’s adjuvant-induced arthritic rats, there was a significant increase in the rat paw volume and decrease in body weight, but in Sw-SP- and Ho-SP-treated groups (10 mg/kg), a significant reduction in paw volume and a normal gain in body weight were observed. The present results indicate that Sw-SP and Ho-SP possess antinociceptive and anti-inflammatory effects and have potential usefulness for development as therapeutic agents.
Paulraj Kanmani,Venkatesan Arul,Ramraj Satishkumar,Neelakandan Yuvaraj,Kupusamy Alagesan Paari,Vellaiyan Pattukumar 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.3
The aim of this study was to optimize medium composition for higher yield of total viable cells and bacteriocin by Enterococcus faecium MC13. The factors such as peptone, meat extract, yeast extract, lactose, glycerol, tween 80,triammonium citrate and K-2HPO_4 were selected based on the Lactobacillus MRS medium composition. Two level factorial designs (FD) and steepest ascent path were performed to identify vital factors among the variables. Through the 2^(−8)FD, peptone, yeast extract and lactose were found to be significant factors involved in the enhanced production of viable cells and bacteriocin. Therefore, these three foremost factors were further optimized by central composite design to achieve efficient yield. The optimum MRS composition was found to be peptone (40.0 g/L), meat extract (30.0 g/L),yeast extract (40.0 g/L), lactose (24.0 g/L), glycerol (5.8 g/L), Tween 80 (3.0 g/L), triammonium citrate (1.0 g/L), K_2HPO_4(2.5 g/L), MgSO_4·7H_2O (0.10 g/L), MnSO-4·7H_2O (0.05 g/L) and dipotassium PO_4 (2.0 g/L). The optimized growth medium allowed higher amount of bacteriocin activity (36,100 AUml^(−1)) and total viable cells (14.22 LogCFUml^(−1))production which were two-times higher than the commercial MRS medium.