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RISS 인기검색어
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- 저자 : Nazrul Haq (검색결과 3 건)
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Faiyaz Shakeel,Nazrul Haq,Fars K. Alanazi,Ibrahim A. Alsarra 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.56 No.-
The solubility of apremilast (APM) in different “Transcutol1+ water” cosolvent mixtures was determined and correlated at “T = 298.2 K–318.2 K” and ‘p = 0.1 MPa’. The experimental solubilities of APM were determined and correlated with “Apelblat, van’t Hoff, Yalkowsky and Jouyban–Acree equations”. The maximum solubilities of APM in mole fraction were obtained in neat Transcutol (2.53 102 at T = 318.2 K). Based on activity coefficients, strong molecular interactions were obtained between APM and neat Transcutol in comparison with APM and neat water. “Apparent thermodynamic analysis” showed an “endothermic and entropy-driven dissolution” of APM.
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Gamal A. Shazly,Nazrul Haq,Faiyaz Shakeel 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.6
Solution thermodynamics and solubility of glibenclamide(GBN) in binary co-solvent mixtures of Transcutol? water at temperature range of 298.15–333.15 Kwere investigated in present study. The modified Apelblatmodel was used to predict the solubility of GBN in co-solventmixtures at various temperatures. The highest andlowest solubility of GBN were observed in pure Transcutoland pure water, respectively. Moreover, all co-solvent mixtureshad highest solubility at 333.15 K. The experimentalsolubility data of GBN was correlated well with the modifiedApelblat model at each temperature studied with relativeabsolute deviation in the range of 0.008–5.903 %. The correlationcoefficients in co-solvent mixtures were observed inthe range of 0.995–0.999 which indicated good fitting ofexperimental data with calculated one. The enthalpies andentropies for GBN dissolution were observed in the range of2.012–38.215 kJ mol-1 and 6.748–114.709 J mol-1 K-1,respectively indicating its dissolution is endothermic and anentropy-driven process. These results indicated that Transcutolcan be used as a co-solvent in preformulation studiesand formulation development of GBN.
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Relationship Between Vitamin D Status and Brain Perfusion in Neuropsychiatric Lupus
Nasreen Sultana,Azmal Kabir Sarkar,Hiroshi Matsuda,Amimul Ihsan,Syed Atiqul Haq,Saidul Arefin,Sheikh Nazrul Islam 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.3
Purpose Neuropsychiatric manifestation of lupus (NPSLE) is related with vitamin D (vit-D) deficiency which is possibly amenable to supplementation. This study was done to explore link of serum vit-D level and clinical mini-mental state examination (MMSE) with brain perfusion SPECT (BS) in patients with NPSLE. Methods Patients who underwent BS with the diagnosis of NPSLE and had serum levels of vit-D andMMSE within a span of 1 month were retrospectively included. The BS DICOM data were used to generate 3D surface images of brain for visual identification of regional hypoperfusion, and the z-scores from eZIS software and then to performvoxel-based regression analysis in order to explore association between serum vit-D level and cerebral perfusion deficit using SPM8. Distribution of serum vit-D level was checked across MMSE and BS z-score using R. Results A total 19 patients with means ± SD age of 28.4 ± 9.2 years, having mean levels of serum vit-D of 18.7 ± 9.8 ng/ml and meanMMSE scores 24.2 ± 1.6, had undergone BS. The eZIS-derived z-score fall in the category of normal in six (31.6%), mild perfusion deficit (PD) in 10 (52.6%) and moderate PD in three (15.8%) with the means ± SD of z-score being 0.52 ± 0.2, 1.72 ± 0.2, and 2.33 ± 0.2. Voxel-based analysis revealed significant positive correlation between vit-D level and hypoperfusion in brain regions related to cognitive function (p<0.05). Serum vit-D levels were significantly lower in NPSLE patients with lowerMMSE scores as well as in higher eZIS z-score (p < 0.01). Conclusions Our results may support the utility of vit-D supplementation in NPSLE and applicability of BS as a clinical adjunct for monitoring response to vit-D supplementation.
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