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Faiyaz Shakeel,Nazrul Haq,Fars K. Alanazi,Ibrahim A. Alsarra 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.56 No.-
The solubility of apremilast (APM) in different “Transcutol1+ water” cosolvent mixtures was determined and correlated at “T = 298.2 K–318.2 K” and ‘p = 0.1 MPa’. The experimental solubilities of APM were determined and correlated with “Apelblat, van’t Hoff, Yalkowsky and Jouyban–Acree equations”. The maximum solubilities of APM in mole fraction were obtained in neat Transcutol (2.53 102 at T = 318.2 K). Based on activity coefficients, strong molecular interactions were obtained between APM and neat Transcutol in comparison with APM and neat water. “Apparent thermodynamic analysis” showed an “endothermic and entropy-driven dissolution” of APM.
Gamal A. Shazly,Nazrul Haq,Faiyaz Shakeel 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.6
Solution thermodynamics and solubility of glibenclamide(GBN) in binary co-solvent mixtures of Transcutol? water at temperature range of 298.15–333.15 Kwere investigated in present study. The modified Apelblatmodel was used to predict the solubility of GBN in co-solventmixtures at various temperatures. The highest andlowest solubility of GBN were observed in pure Transcutoland pure water, respectively. Moreover, all co-solvent mixtureshad highest solubility at 333.15 K. The experimentalsolubility data of GBN was correlated well with the modifiedApelblat model at each temperature studied with relativeabsolute deviation in the range of 0.008–5.903 %. The correlationcoefficients in co-solvent mixtures were observed inthe range of 0.995–0.999 which indicated good fitting ofexperimental data with calculated one. The enthalpies andentropies for GBN dissolution were observed in the range of2.012–38.215 kJ mol-1 and 6.748–114.709 J mol-1 K-1,respectively indicating its dissolution is endothermic and anentropy-driven process. These results indicated that Transcutolcan be used as a co-solvent in preformulation studiesand formulation development of GBN.