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        Manuka Honey versus Antibiotic Ear Drops in Healing of Post-Operative Mastoid Cavity: A Prospective Randomized Trial

        Niveditha Damodharan,Roshan Kumar Verma,Archana Angrup,Naresh K Panda,Naresh K Panda 대한이비인후과학회 2020 대한이비인후과학회지 두경부외과학 Vol.63 No.5

        Background and Objectives This study investigates the role of manuka honey in the healingof postoperative mastoid cavity. Subjects and Method This was a single centre prospective study on 40 consecutive patientsof chronic otitis media undergoing canal wall down mastoidectomy. Manuka honey soaked ingel foam was kept in the mastoid cavity for the study group and antibiotic soaked gel foam waskept for the control group. Culture swabs from mastoid granulations were sent at various timesfrom both groups. The healing of the mastoid cavity was assessed in the follow up period. Results Preoperatively 15 out of 20 patients (75%) had a positive aural swab culture in thestudy group while 11 out of 20 (55%) in the control group had a positive aural swab culture. Themost common organism isolated was Pseudomonas aeruginosa and Proteus mirabilis. Onemonth after mastoidectomy only 4 patients (20%) had sterile culture and 16 patients (80%) hadgrown organisms; in the control group, 7 patients (35%) had sterile culture and 13 patients (65%)had growth on culture. The mean merchant scores for the study group and the control were 2.61(2-5) and 2.05 (1-4), respectively. At 3 months 13 patients (65%) with sterile culture and 7 patients(35%) had growth on culture; in the control group, 16 patients (80%) had sterile cultureand 4 had shown persistent growth on culture (p=0.28). All positive cultures were aerobic inboth groups. The mean merchant scores for the study group and the control were 1.03 (0-4)and 0.7 (0-3), respectively (p=0.09). Conclusion Healing of mastoid cavity was almost similar in both groups (p>0.05). Manukahoney exhibited antibacterial activity against Pseudomonas, Proteus, Klebsiella, Escherichiacoli, Staphylococcus

      • KCI등재

        A prospective randomized trial of xylometazoline drops and epinephrine merocele nasal pack for reducing epistaxis during nasotracheal intubation

        Patel, Sonam,Hazarika, Amarjyoti,Agrawal, Prachi,Jain, Divya,Panda, Naresh Kumar The Korean Dental Society of Anesthsiology 2020 Journal of Dental Anesthesia and Pain Medicine Vol.20 No.4

        Background: The most frequent complication of nasotracheal intubation (NTI) is epistaxis. Epinephrine nasal gauze packing has been used conventionally as a pre-treatment for reducing epistaxis, but it carries a disadvantage of pain and anxiety in patients. However, xylometazoline drops are easier to administer and more convenient for patients. We aimed at comparing the effectiveness of xylometazoline drops and epinephrine merocele packing in reducing bleeding and postoperative complications in our population. Methods: Our study enrolled 120 patients in a double-blind randomized controlled trial. We randomly allocated ASA1 or 2 adult patients into 2 groups: Group X and Group E. Group X received 0.1% xylometazoline nasal drops, and epinephrine (1:10,000) merocele nasal packing was used in Group E. The primary outcome was the incidence of bleeding during NTI; the severity of bleeding, navigability, bleeding during extubation, and postoperative complications were secondary outcomes. We used IBM SPSS and Minitab software for statistical analysis, and P < 0.05 was considered statistically significant. Results: We analyzed the data of 110 patients: 55 in Group X and 55 in Group E. The two groups did not have different bleeding incidence (56.4% vs 60.0%; P = 0.70); however, the incidence of severe bleeding was less with xylometazoline than with epinephrine (3.63% vs 14.54%; P < 0.05). We also observed less bleeding during extubation (38.2% vs 68.5%; P < 0.05) with xylometazoline. Other secondary outcomes were akin to both groups. Conclusion: The incidence of severe and post-extubation bleeding was significantly less with xylometazoline. Hence, it may be an effective alternative for reducing the incidence and severity of epistaxis during NTI.

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        Angiogenesis-Targeted 68Ga-DOTA-RGD2 PET/CT Imaging: a Potential Theranostic Application in the Case of Chondrosarcoma

        Venkata Subramanian Krishnaraju,Kumar Rajender,Sood Ashwani,Jaya Shukla,Karthikeyan Subramanian,Nandita Kakkar,Naresh Panda,Mittal Bhagwant Rai 대한핵의학회 2021 핵의학 분자영상 Vol.55 No.3

        Chondrosarcoma is a cartilaginous tumor of mesenchymal origin. The histology and grade of the tumor determine the chances of relapse and survival. These tumors usually respond poorly to chemo-radiotherapy in cases of non-resectable and recurrent disease. 18F-FDG PET/CT has been used in evaluation of recurrence. However, these tumors show only mild to moderate FDG avidity due to their lower mitotic activity and large acellular matrix. These tumors are known to have a high degree of angiogenesis, especially in those of higher grade. We present a case of a 53-year-old man with grade II chondrosarcoma of the left femur showing only mild avidity on 18F-FDG PET/CT but showing moderate to intense tracer avidity on 68Ga-DOTA-RGD2 PET/CT. This may enable the use of angiogenesis-targeted positron and beta-emitting radiopharmaceuticals as a potentially new theranostic alternative treatment in cases of refractory metastatic chondrosarcoma.

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