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      • PTEN 유전자 돌연변이를 동반한 Cowden병 1예

        남성진,최영식,박요한,김규종,박선자 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

        Cowden's disease, also known as various hamartomatous malformations of multiple organs, is a rare autosomal dominant disorder. The most important feature of Cowden's disease is an increased incidence of malignant neoplasm, particularly in the breast and thyroid gland. PTEN (phosphatase and tensin homologue deleted in chromosome 10) is a candidate tumor suppressor gene. Mutations of this gene are responsible for PTEN hamartoma tumor syndromes, including Cowden's disease, Bannayan-Riley-Ruvalcaba syndrome, Proteus syndrome, and Proteus-like syndromes. After identification of PTEN as the gene for Cowden's disease, the incidence of Cowden's disease was estimated to be 1 in 200,000. However Cowden's disease with malignant neoplasm is quite rare in Korea so far. Recently we experienced a family with Cowden's disease who carry a frame shift germline mutation(C.606del T) at 10q23, exon 6 of PTEN gene. The authors report this case with literature review.

      • KCI등재후보

        전기 치수 검사 시 역치 자극 이후 과용(過用) 자극 시간의 측정

        남기창,안선희,김수찬,김덕원,이승종 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.3

        Use of electric pulp testing elicits painful response in vital teeth. In this study, we examined the excessive time from pain feeling to stimulation disconnection in clinical situation. D626D (Parkell Inc., USA.) scan type electric pulp tester was used in total of 23 young healthy individuals. Each of the right central incisors and first premolars were used as testing teeth. Stimulation disconnection was achieved by EMG in anterior belly of digastric muscle, finger span, and voice and the excessive stimulation time over the sensory threshold was recorded. As a result, we found that the short responses before the stimulation disconnection appeared following order: EMG, finger span, and voice. The EMG disconnection is suggested to be used to reduce the excessive stimulus time in electric pulp testing.

      • 고정벽체에 작용하는 횡토압에 대한 모형실험

        남선우,김문규,배선호 동아대학교 건설기술연구소 1997 硏究報告 Vol.21 No.2

        To examine lateral earth pressure against fixed wall due to geometry of backfill, a model test was carried out. Soil box (180×75×80mm), 2-directional load cell and rainer were made for this test. And Sumjin river sand as backfill materal was placed in the backfill space with different geometries and relative densities. This test result was compared with the extended Silo theory(Chung et at, 1997) and Jaky's lateral pressure at rest. The comparative results are as follows : When the bottom width between the model wall and the stable slope is narrow, the experimental pressure agree well with that of the extended theory, independent of inclinations of wall and stable slope. However, when the width is not narrow, ie, when Bc/H is larger then 0.333, the experimental pressure is preferably close to the Jaky's lateral pressure at rest. The angle of wall friction have an important effet on the experimental lateral pressure, as wall as bottom width. The wall friction angle was measured the peak at lower placing height, and just after that the value is roughly constant up to the residual state.

      • KCI등재

        國際貿易法來에서의 信用狀去來 詐欺事作의 對處方案

        南善模 韓國仲裁學會 2008 중재연구 Vol.18 No.2

        A letter of credit transaction of the preexistence have been raising one's head fraud charge problem as a result of abusing the principles of independence and abstraction. Every society has certain rules and conventions which it regards as important and most of people in any society. The paper document means a document in a traditional paper form. The eUCP credit must specify the formats in which electronic records are to be presented. In these present times, the issuance of documentary credit are performed by the SWIFT(Society for Worldwide Inter bank Financial Telecommunication) system. The eUCP have been written to allow for presentation completely electronically or for a mixture of paper documents and electronic presentation. Presentation is deemed not to have been made if the Beneficiary's notice is not received. An electronic record that cannot be authenticated is deemed not to have been presented. The e-UCP is the supplement of current existing UCP but is superior to UCP under some circumstances. The document shall include an electronic record. The place for presentation of electronic records means an electronic address. The current e-UCP is not clear on this matter. We have to note followings in case of presenting the documents electronically and applying the e-UCP. There are three principles in the letter of credit transaction, that is to say, independence and abstraction, document dealing, strict compliance. IN the electronic letter of credit, these principles are called as independence and abstraction, electronic document dealing, strict compliance.

      • 산업폐기물인 폐주물사를 혼입한 콘크리트의 최적배합설계

        박재선,김태경,백민경,이주형,윤경구,김남윤 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

        산업폐기물인 폐주물사를 재활용하여 에너지 절감과 환경오염효과를 얻을 수 있다. 반요인실험법을 사용하여 폐주물사를 잔골재에 일정비율 치환한 콘크리트의 최적배합설계 제시를 위한 예비실험에서 물-시멘트비, 폐주물사의 잔골재 치환율, 잔골재율, 슬럼프와 같은 주요변수와 변수사이의 2차상호작용을 파악하였다. 예비실험결과 폐주물사의 잔골재치환율을 70%까지 실시하였을 때 폐주물사를 혼입한 콘크리트의 강도발현에 가장 중요한 변수는 물-시멘트비로 분석되었고 폐주물사의 잔골재치환율은 거의 영향이 없는 것으로 분석되어 폐주물사를 콘크리트의 잔골재로 대체할 수 있음을 알 수 있었다. 각 변수의 2차상호작용에서는 폐주물사의 잔골재 치환율과 잔골재율의 상관관계가 콘크리트의 강도발현에 가장 큰 영향을 미치는 것으로 나타났다. 목표압축강도에 대한 최적배합조건을 폐주물사의 잔골재 치환율에 따라 물-시멘트비, 잔골재율에 대해 제시하였다. The waste foundry sand might be recycled in concrete, saving energy and protect-ing environment. An half- factorial experiments were performed with the primarary variable such as water- cement raito, waste foundry sand substitution ratio, fine agg-regate ratio and slump as a preliminary study for optimum mix design of concrete. The preliminary study show that the water- cement ratio is the most important factor to the concrete strength, followed by slump. The substitute of waste foundry sand up to 70% has little infulence, indicating that it can substitute the fine aggregate without damaging the Concrete strength. The interaction between waste foundry sand substitution ratio and fine aggregate ratio was most significant to the concrete strength among the 2-way interaction variable. Only compressive strength affect to the formation of optimum mix design area as target compressive strengh becomes bigger. Optimum mix designs of concrete incorporating waste foundry sand, satisfying the target responses, were proposed in terms of waste foundry sand substitution ratio, water cement ratio and fine aggregate ratio.

      • 자궁경부암 냉동조직에서 Polymerase Chain Reaction (PCR)을 이용한 인 유듀종바이러스 (HPV)의 출현과 임상적 특징과의 연관성에 관한 연구

        권선호,남상륜,이증훈,노재랑,최준호 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1

        Infection with human papillomavirus(HPV) is considered to be the principal causal agent in the development of the uterine cervical cancer. To detect HPV types prevalent in carcinoma of the uterine cervix, a type-specific, sensitive polymerase chain reaction(PCR)-based assay for HPV types 16, 18, and 33 was applied to 40 cervical carcinomas(39 squamous cell carcinomas and 1 adenocarcinoma), 6 cases of cervical intraepithelial neoplasia(CIN), and 18 samples of cervicitis and histologically normal cervix. PCR was done using 2 sets of Ll primer of HPV-16 and 18, 1 set of E2/E1 primer of HPV-33, and 3 sets of E6 primer of HPV-16, 18, 33. The amplified product was analyzed directly on the basis of the size of the ethidium bromide-stained band visible after agarose gel electrophoresis, which was confirmed by Southern blot hybridization. The results were as follows : 1. As expected, the combined incidence of the common high-risk genital HPVs(types 16, 18 and 33) was high in carcinomas (82.5%) and CIN 111(66.7%), low in CIN 1(33.3%), and nonexistent in the normal controls. 2. By using L1 primers and E1/E2 primers in 46 CINs and cervical carcinomas, HPV DNA was detected in 36(78.3%), which were 65.2%(30/46) for HPV 16, 8.7%(4/46) for HPV 33, 6.5%(3/46) for HPV-18, and only 1 case of mixed infection of HPV-16 and HPV-18 was detected. All normal cervices and cervicitis tissues were negative for HPV 16, 18 and 33. By using E6 primers, 35 (76.1%) cases were positive for HPV DNA, which were 67.4%(31/46) for HPV-16, 4.3%(2/46) each for HPV-18 and HPV-33. HPV 16 is the most common type present in squamous cell carcinoma. 3. There was no difference in detection rates of HPV DNA according to patients age in cervical carcinoma (p=0.188). 4. There were good correlation between the results obtained by PCR using Ll or E1/2 primer and those by E6 primer. The concordance rates were 93.8%(60/64) for HPV-16, 98.4% for HPV-18, and 96.9% for HPV-33. 5. There was no difference in detection rates of HPV DNA according to clinical stage in cervical carcinoma(p=0.2). 6. The detection rate of HPV DNA in case of serum SCC level under lOng/ml was 100%(17/17), which was higher than those in cases of serum SCC levels of 10ng/ml or more. "The detection rate was significantly decreased as serum SCC became high in level(p=0.012). 7. There was no difference in detection rates of HPV DNA according to tumor size in cervical carcinoma (p=0.743). 8. The reccurrence rate of patients with HPV-16 containing tumors was 28.6%((8/28), which was 3.4 times more than that of patients without HPV-16, but it was not statistically significant(p=0.162). The survival rate of patients with HPV-16 containing tumors was 82.1%, which was not different from from that of patients without HPV-16 containing tumrs(p=0.405). In conclusion, papillomavirus, especially HPV-16, played some role in the development of cervical cancer. There was no association between the HPV infection and the clinical characteristics including prognosis. However, in contrast to other studies, HPV type 18 and 33 were not the common type of HPV. Perhaps more cases should be analyzed.

      • KCI등재

        대용섬유자원으로써 어저귀를 이용한 한지제조 (제2보) : 인피 및 목질부 섬유를 이용한 한지 제조 Manufacturing of The Hanjis Made from Bast Fiber and woody core fibers

        정선화,조남석,최태호 한국목재공학회 2004 목재공학 Vol.32 No.1

        생장속도가 빨라서 단위면적당 Biomass의 생산량이 많은 어저귀(Indian mallow, Abutilon avicennae G.)를 원료로 하여 펄프화하였으며, 제조한 한지의 물리적·기계적·현미경적 특성에 관하여 비교 검토하였다. 제조한 한지의 특성을 살펴보면 광학적, 강도적 현미경적인 특성에서 설포메틸 펄프화법이 우수한 결과를 나타냈고, 장섬유인 인피부 펄프에 대한 단섬유인 목질부 펄프의 혼입량 증가에 따른 변화에 있어 지질(밀도, 백색도, 불투명도, 지합)의 변화는 점차 증가했으나, 강도는 감소하는 경향을 나타냈다. This study was carried out to investigate the sheet properties of Indian mallow Hanji, made by different pulping methods, such as alkali and sulfomethylated pulpings, and different stock compositions, various mixing ratios of bast fiber and woody core fibers. Indian mallow hanjis made from the sulfomethylated pulps had higher brightness and sheet strength than the alkali pulps. It was found that the brightness of sulfomethylated pulp was enough high without an extra-bleaching. In the mechanical properties of Indian mallow hanjis mixed with bast fiber and woody core stalk pulps, the sheet strength were decreased as wood core pulps contents were increased. The sheet formation were increased as the increase of woody core pulps contents, while the sheet strength decreased Although the sulfomethylated pulping resulted in higher pulp yield, no morphological differences of fiber surfaces were shown as compared to the different pulping methods.

      • KCI등재

        Rieger 증후군의 증례

        김선희,양규호,김용남 大韓小兒齒科學會 1988 大韓小兒齒科學會誌 Vol.15 No.1

        The major manifestations of Rieger's syndrome are ocular and dental abnormalities. The ocular abnorma-lities include partial or complete hypoplasia of the iris stroma, the presence of iris strands crossing the angle of the anterior chamber of the eye, and the presence of posterior embryotoxon. Hypodontia, microdontia, peg shaped teeth, and malocclusion (bilateral cross-bites) are common oral findings. Hypoplasia of the maxilla causes the mandible to appear prominent. The authors observed a patient with Rieger's syndrome who was a 13year-old girl. With reserach of literature, the case is presented.

      • KCI등재

        괴사성 치은구내염환아의 증례보고 : CASE REPORT

        최남기,정희경,양규호,김선미 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

        괴사성 치은염(Necrotizing ulcerative gingivitis, NUG), 괴사성 치주염(necrotizing ulcerative periodontitis, NUP),괴사성 구내염(necrotizing stomatits, NS), 그리고 수암(noma, cancrum oris)은 급속도로 파괴적이며 쇠약하게 하는 잠재성이 큰 구강감염으로 질환의 같은 진행과정에 대해 다른 임상단계로 간주되기도 하나 집합적으로 Vincent's infection, infectious oral necrosis 또는 괴사성 치은구내염(Necrotizing gingivostomati-tis, NG)라고 한다. 이러한 necrotizing gingivostomatitis(NG)의 발생률은 0.19~0.5%이며 2~6세에 가장 높은 발병율을 보인다. Necrotizing gingivostomati-tis는 치명적인 바이러스 감염과 면역체계가 약화된 경우 발생할 수 있으며 주 진단학적 증상으로 동통, 치간유두 부위의 궤양이나 괴사, 치은출혈이 있으며 이차적인 증상은 위막 등이 있다. 이에 본원 소아과에서 의뢰되어 necrotizing gingivostomatitis로 진단받은 환아의 구강내 소견 및 치료경과에 대해 보고하고자 한다. Necrotizing ulcerative gingivitis(NUG), necrotizing ulcerative periodontitis(NUP), necrotizing stomatitis(NS), and Noma(cnacrum oris) are rapidly destructive, debilitating, and potentially serious oral infection which considered to be different clinical stages of the same process. These have been collectively referred to as: Vincent's infection, infectious oral necrosis, or necrotizing gingivostomatitis(NG). Prevalence of necrotizing gingivostomatitis is 0.19~0.5% and peak incidence is 2-6 years of age. The etiology and pathogenesis of necrotizing gingivostomatitis have been associated with virulent bacteria and impaired host defense and the primary diagnostic signs are pain. interdental ulceration or necrosis. and gingival bleeding. Secondary diagnostic sign is pseudomembrane. This case report was about oral conditions and treatment of the patient who referred from the Dept. of PED and diagnosed a necorotizing gingivostomatitis.

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